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MetaCyc Reaction: 2.1.1.80

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical ReactionsProtein-Modification Reactions
Reactions Classified By SubstrateMacromolecule ReactionsProtein-ReactionsProtein-Modification Reactions

EC Number: 2.1.1.80

Enzymes and Genes:

Escherichia coli K-12 substr. MG1655: chemotaxis protein methyltransferaseInferred from experiment: cheR

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Enzyme Commission Primary Name: protein-glutamate O-methyltransferase

Enzyme Commission Synonyms: methyl-accepting chemotaxis protein O-methyltransferase, S-adenosylmethionine-glutamyl methyltransferase, methyl-accepting chemotaxis protein methyltransferase II, S-adenosylmethionine:protein-carboxyl O-methyltransferase, protein methylase II, MCP methyltransferase I, MCP methyltransferase II, protein O-methyltransferase, protein(aspartate)methyltransferase, protein(carboxyl)methyltransferase, protein carboxyl-methylase, protein carboxyl-O-methyltransferase, protein carboxylmethyltransferase II, protein carboxymethylase, protein carboxymethyltransferase, protein methyltransferase II

Taxonomic Range: Archaea, Bacteria

Standard Gibbs Free Energy (ΔrG in kcal/mol): -35.519257Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Forms ester groups with L-glutamate residues in a number of membrane proteins.

Citations: [BurgessCassler82, Kleene77, Simms87, Springer77]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R02623

Relationship Links: BRENDA:EC:2.1.1.80, ENZYME:EC:2.1.1.80, IUBMB-ExplorEnz:EC:2.1.1.80, UniProt:RELATED-TO:P07364, UniProt:RELATED-TO:P07801, UniProt:RELATED-TO:P45676


References

BurgessCassler82: Burgess-Cassler A, Ullah AH, Ordal GW (1982). "Purification and characterization of Bacillus subtilis methyl-accepting chemotaxis protein methyltransferase II." J Biol Chem 257(14);8412-7. PMID: 6806296

Kleene77: Kleene SJ, Toews ML, Adler J (1977). "Isolation of glutamic acid methyl ester from an Escherichia coli membrane protein involved in chemotaxis." J Biol Chem 252(10);3214-8. PMID: 16888

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Simms87: Simms SA, Stock AM, Stock JB (1987). "Purification and characterization of the S-adenosylmethionine:glutamyl methyltransferase that modifies membrane chemoreceptor proteins in bacteria." J Biol Chem 262(18);8537-43. PMID: 3298235

Springer77: Springer WR, Koshland DE (1977). "Identification of a protein methyltransferase as the cheR gene product in the bacterial sensing system." Proc Natl Acad Sci U S A 74(2);533-7. PMID: 322131


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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