Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 2.1.1.80

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Protein-Modification Reactions
Reactions Classified By Substrate Macromolecule Reactions Protein-Reactions Protein-Modification Reactions

EC Number: 2.1.1.80

Enzymes and Genes:
chemotaxis protein methyltransferase Inferred from experiment : cheR ( Escherichia coli K-12 substr. MG1655 )

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: protein-glutamate O-methyltransferase

Enzyme Commission Synonyms: methyl-accepting chemotaxis protein O-methyltransferase, S-adenosylmethionine-glutamyl methyltransferase, methyl-accepting chemotaxis protein methyltransferase II, S-adenosylmethionine:protein-carboxyl O-methyltransferase, protein methylase II, MCP methyltransferase I, MCP methyltransferase II, protein O-methyltransferase, protein(aspartate)methyltransferase, protein(carboxyl)methyltransferase, protein carboxyl-methylase, protein carboxyl-O-methyltransferase, protein carboxylmethyltransferase II, protein carboxymethylase, protein carboxymethyltransferase, protein methyltransferase II

Standard Gibbs Free Energy (ΔrG in kcal/mol): -35.519257 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Forms ester groups with L-glutamate residues in a number of membrane proteins.

Citations: [BurgessCassler82, Kleene77, Simms87, Springer77]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R02623

Relationship Links: BRENDA:EC:2.1.1.80 , ENZYME:EC:2.1.1.80 , IUBMB-ExplorEnz:EC:2.1.1.80 , UniProt:RELATED-TO:P07364 , UniProt:RELATED-TO:P07801 , UniProt:RELATED-TO:P45676


References

BurgessCassler82: Burgess-Cassler A, Ullah AH, Ordal GW (1982). "Purification and characterization of Bacillus subtilis methyl-accepting chemotaxis protein methyltransferase II." J Biol Chem 257(14);8412-7. PMID: 6806296

Kleene77: Kleene SJ, Toews ML, Adler J (1977). "Isolation of glutamic acid methyl ester from an Escherichia coli membrane protein involved in chemotaxis." J Biol Chem 252(10);3214-8. PMID: 16888

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Simms87: Simms SA, Stock AM, Stock JB (1987). "Purification and characterization of the S-adenosylmethionine:glutamyl methyltransferase that modifies membrane chemoreceptor proteins in bacteria." J Biol Chem 262(18);8537-43. PMID: 3298235

Springer77: Springer WR, Koshland DE (1977). "Identification of a protein methyltransferase as the cheR gene product in the bacterial sensing system." Proc Natl Acad Sci U S A 74(2);533-7. PMID: 322131


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Mon Nov 24, 2014, biocyc13.