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MetaCyc Reaction: 6.2.1.22

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical ReactionsProtein-Modification Reactions
Reactions Classified By SubstrateMacromolecule ReactionsProtein-ReactionsProtein-Modification Reactions

EC Number: 6.2.1.22

Enzymes and Genes:

Klebsiella pneumoniae: [citrate [pro-3S]-lyase] ligaseInferred from experiment: citC

In Pathway: citrate lyase activation

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Enzyme Commission Primary Name: [citrate (pro-3S)-lyase] ligase

Enzyme Commission Synonyms: citrate lyase ligase, citrate lyase synthetase, acetate: SH-[acyl-carrier-protein] enzyme ligase (AMP), acetate:HS-citrate lyase ligase, acetate:citrate-(pro-3S)-lyase(thiol-form) ligase (AMP-forming)

Standard Gibbs Free Energy (ΔrG in kcal/mol): -31.734009Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Both this enzyme and EC 2.3.1.49,deacetyl-[citrate-(pro-3S)-lyase] S-acetyltransferase, acetylate and activate EC 4.1.3.6, citrate (pro-3S)-lyase.

Citations: [Schmellenkamp74 , Quentmeier85, Antranikian85, Antranikian82]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R04449

Relationship Links: BRENDA:EC:6.2.1.22, ENZYME:EC:6.2.1.22, IUBMB-ExplorEnz:EC:6.2.1.22, UniProt:RELATED-TO:P44462, UniProt:RELATED-TO:P45410, UniProt:RELATED-TO:Q9CGB0, UniProt:RELATED-TO:Q9RLT7


References

Antranikian82: Antranikian G, Gottschalk G (1982). "Copurification of citrate lyase and citrate lyase ligase from Rhodopseudomonas gelatinosa and subsequent separation of the two enzymes." Eur J Biochem 126(1);43-7. PMID: 7128585

Antranikian85: Antranikian G, Herzberg C, Gottschalk G (1985). "Covalent modification of citrate lyase ligase from Clostridium sphenoides by phosphorylation/dephosphorylation." Eur J Biochem 153(2);413-20. PMID: 3935436

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Quentmeier85: Quentmeier A, Antranikian G (1985). "Characterization of citrate lyase from Clostridium sporosphaeroides." Arch Microbiol 141(1);85-90. PMID: 3994485

Schmellenkamp74: Schmellenkamp H, Eggerer H (1974). "Mechanism of enzymic acetylation of des-acetyl citrate lyase." Proc Natl Acad Sci U S A 71(5);1987-91. PMID: 4365579


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Tue Jan 1, 2002, biocyc12.