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MetaCyc Reaction: 6.2.1.22

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Protein-Modification Reactions
Reactions Classified By Substrate Macromolecule Reactions Protein-Reactions Protein-Modification Reactions

EC Number: 6.2.1.22

Enzymes and Genes:

Klebsiella pneumoniae : [citrate [pro-3S]-lyase] ligase Inferred from experiment : citC

In Pathway: citrate lyase activation

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Enzyme Commission Primary Name: [citrate (pro-3S)-lyase] ligase

Enzyme Commission Synonyms: citrate lyase ligase, citrate lyase synθse, acetate: SH-[acyl-carrier-protein] enzyme ligase (AMP), acetate:HS-citrate lyase ligase, acetate:citrate-(pro-3S)-lyase(thiol-form) ligase (AMP-forming)

Standard Gibbs Free Energy (ΔrG in kcal/mol): -31.734009 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Both this enzyme and EC 2.3.1.49,deacetyl-[citrate-(pro-3S)-lyase] S-acetyltransferase, acetylate and activate EC 4.1.3.6, citrate (pro-3S)-lyase.

Citations: [Schmellenkamp74, Quentmeier85, Antranikian85, Antranikian82]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: KEGG:R04449

Relationship Links: BRENDA:EC:6.2.1.22 , ENZYME:EC:6.2.1.22 , IUBMB-ExplorEnz:EC:6.2.1.22 , UniProt:RELATED-TO:P44462 , UniProt:RELATED-TO:P45410 , UniProt:RELATED-TO:Q9CGB0 , UniProt:RELATED-TO:Q9RLT7


References

Antranikian82: Antranikian G, Gottschalk G (1982). "Copurification of citrate lyase and citrate lyase ligase from Rhodopseudomonas gelatinosa and subsequent separation of the two enzymes." Eur J Biochem 126(1);43-7. PMID: 7128585

Antranikian85: Antranikian G, Herzberg C, Gottschalk G (1985). "Covalent modification of citrate lyase ligase from Clostridium sphenoides by phosphorylation/dephosphorylation." Eur J Biochem 153(2);413-20. PMID: 3935436

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Quentmeier85: Quentmeier A, Antranikian G (1985). "Characterization of citrate lyase from Clostridium sporosphaeroides." Arch Microbiol 141(1);85-90. PMID: 3994485

Schmellenkamp74: Schmellenkamp H, Eggerer H (1974). "Mechanism of enzymic acetylation of des-acetyl citrate lyase." Proc Natl Acad Sci U S A 71(5);1987-91. PMID: 4365579


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Fri Aug 28, 2015, BIOCYC14A.