Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 1.8.1.14

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.8.1.14

Supersedes EC number: 1.6.4.10

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: CoA-disulfide reductase

Enzyme Commission Synonyms: CoA-disulfide reductase (NADH2), NADH2:CoA-disulfide oxidoreductase, CoA:NAD+ oxidoreductase (misleading), CoADR, coenzyme A disulfide reductase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -20.025146 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A flavoprotein. Not identical with EC 1.8.1.6, cystine reductase, EC 1.8.1.7, glutathione-disulfide reductase or EC 1.8.1.13, bis-γ-glutamylcystine reductase. The enzyme from the bacterium Staphylococcus aureus has a strong preference for NADPH [Luba99], while the bacterium Bacillus megaterium contains both NADH and NADPH-dependent enzymes [Setlow77].

Citations: [delCardayre98]

Unification Links: KEGG:R07175

Relationship Links: BRENDA:EC:1.8.1.14 , ENZYME:EC:1.8.1.14 , IUBMB-ExplorEnz:EC:1.8.1.14 , Rhea:RELATED-TO:14704 , Rhea:RELATED-TO:14708


References

delCardayre98: delCardayre SB, Stock KP, Newton GL, Fahey RC, Davies JE (1998). "Coenzyme A disulfide reductase, the primary low molecular weight disulfide reductase from Staphylococcus aureus. Purification and characterization of the native enzyme." J Biol Chem 273(10);5744-51. PMID: 9488707

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Luba99: Luba J, Charrier V, Claiborne A (1999). "Coenzyme A-disulfide reductase from Staphylococcus aureus: evidence for asymmetric behavior on interaction with pyridine nucleotides." Biochemistry 38(9);2725-37. PMID: 10052943

Setlow77: Setlow B, Setlow P (1977). "Levels of acetyl coenzyme A, reduced and oxidized coenzyme A, and coenzyme A in disulfide linkage to protein in dormant and germinated spores and growing and sporulating cells of Bacillus megaterium." J Bacteriol 132(2);444-52. PMID: 410791


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Fri Nov 21, 2014, biocyc14.