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MetaCyc Reaction: 1.4.3.3

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.4.3.3

Enzymes and Genes:

Homo sapiens : D-amino acid oxidase Inferred from experiment : DAO

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Instance reactions:
D-alanine + H2O + oxygen → pyruvate + ammonium + hydrogen peroxide (1.4.3.19)

D-glutamate + oxygen + H2O → ammonium + hydrogen peroxide + 2-oxoglutarate (1.4.3.7/1.4.3.15)

Enzyme Commission Primary Name: D-amino-acid oxidase

Enzyme Commission Synonyms: ophio-amino-acid oxidase, L-amino acid:O2 oxidoreductase, new yellow enzyme

Taxonomic Range: Metazoa , Bacteria , Fungi

Standard Gibbs Free Energy (ΔrG in kcal/mol): 17.497353 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A flavoprotein (FAD). Wide specificity for D-amino acids. Also acts on glycine.

Citations: [MASSEY61, DIXON65, DIXON65a]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Instance reactions of [a D-amino acid + oxygen + H2O → ammonium + hydrogen peroxide + a 2-oxo carboxylate] (1.4.3.3):
i1: D-alanine + H2O + oxygen → pyruvate + ammonium + hydrogen peroxide (1.4.3.19)

i2: D-glutamate + oxygen + H2O → ammonium + hydrogen peroxide + 2-oxoglutarate (1.4.3.7/1.4.3.15)

Unification Links: KEGG:R01340 , Rhea:21816

Relationship Links: BRENDA:EC:1.4.3.3 , ENZYME:EC:1.4.3.3 , IUBMB-ExplorEnz:EC:1.4.3.3 , UniProt:RELATED-TO:P00371 , UniProt:RELATED-TO:P18894 , UniProt:RELATED-TO:P22942 , UniProt:RELATED-TO:Q28382 , UniProt:RELATED-TO:Q99042


References

DIXON65: DIXON M, KLEPPE K (1965). "D-AMINO ACID OXIDASE. 3. EFFECT OF PH." Biochim Biophys Acta 96;383-9. PMID: 14314379

DIXON65a: DIXON M, KLEPPE K (1965). "D-AMINO ACID OXIDASE. I. DISSOCIATION AND RECOMBINATION OF THE HOLOENZYME." Biochim Biophys Acta 96;357-67. PMID: 14314378

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

MASSEY61: MASSEY V, PALMER G, BENNETT R (1961). "The purification and some properties of D-amino acid oxidase." Biochim Biophys Acta 48;1-9. PMID: 13767909


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Mon Aug 31, 2015, BIOCYC14A.