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MetaCyc Reaction: 1.4.3.3

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 1.4.3.3

Enzymes and Genes:

Homo sapiens: D-amino acid oxidaseInferred from experiment: DAO

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Instance reactions:
D-alanine + H2O + oxygen → pyruvate + ammonium + hydrogen peroxide (1.4.3.19)

D-glutamate + oxygen + H2O → ammonium + hydrogen peroxide + 2-oxoglutarate (1.4.3.7/1.4.3.15)

Enzyme Commission Primary Name: D-amino-acid oxidase

Enzyme Commission Synonyms: ophio-amino-acid oxidase, L-amino acid:O2 oxidoreductase, new yellow enzyme

Taxonomic Range: Metazoa, Bacteria , Fungi

Standard Gibbs Free Energy (ΔrG in kcal/mol): 17.497353Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A flavoprotein (FAD). Wide specificity for D-amino acids. Also acts on glycine.

Citations: [MASSEY61, DIXON65, DIXON65a]

Gene-Reaction Schematic

Gene-Reaction Schematic

Instance reactions of [a D-amino acid + oxygen + H2O → ammonium + hydrogen peroxide + a 2-oxo carboxylate] (1.4.3.3):
i1: D-alanine + H2O + oxygen → pyruvate + ammonium + hydrogen peroxide (1.4.3.19)

i2: D-glutamate + oxygen + H2O → ammonium + hydrogen peroxide + 2-oxoglutarate (1.4.3.7/1.4.3.15)

Unification Links: KEGG:R01340, Rhea:21816

Relationship Links: BRENDA:EC:1.4.3.3, ENZYME:EC:1.4.3.3, IUBMB-ExplorEnz:EC:1.4.3.3, UniProt:RELATED-TO:P00371, UniProt:RELATED-TO:P18894, UniProt:RELATED-TO:P22942, UniProt:RELATED-TO:Q28382, UniProt:RELATED-TO:Q99042


References

DIXON65: DIXON M, KLEPPE K (1965). "D-AMINO ACID OXIDASE. 3. EFFECT OF PH." Biochim Biophys Acta 96;383-9. PMID: 14314379

DIXON65a: DIXON M, KLEPPE K (1965). "D-AMINO ACID OXIDASE. I. DISSOCIATION AND RECOMBINATION OF THE HOLOENZYME." Biochim Biophys Acta 96;357-67. PMID: 14314378

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

MASSEY61: MASSEY V, PALMER G, BENNETT R (1961). "The purification and some properties of D-amino acid oxidase." Biochim Biophys Acta 48;1-9. PMID: 13767909


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Sat Apr 30, 2016, biocyc11.