Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 2.3.1.20

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.3.1.20

Enzymes and Genes:
acyl-CoA:diacylglycerol acyltransferase Inferred from experiment : DGA1 ( Saccharomyces cerevisiae )
wax ester synthase/acyl-CoA diacylglycerol acyltransferase bifunctional enzyme Inferred from experiment : atfA ( Acinetobacter sp. ADP1 )
wax synthase/diacyglycerol acyltransferase [multifunctional] Inferred from experiment : WS1 ( Petunia x hybrida )
acyl-CoA:diacylglycerol acyltransferase Inferred from experiment : TAG1 ( Arabidopsis thaliana col )

In Pathway: triacylglycerol biosynthesis

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: diacylglycerol O-acyltransferase

Enzyme Commission Synonyms: diglyceride acyltransferase, 1,2-diacylglycerol acyltransferase, diacylglycerol acyltransferase, diglyceride O-acyltransferase, palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase, acyl-CoA:1,2-diacylglycerol O-acyltransferase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 325.0658 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Palmitoyl-CoA and other long-chain acyl-CoAs can act as donors.

Citations: [Kawasaki88, Grigor82, Coleman76, WEISS60]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R02251 , Rhea:10868

Relationship Links: BRENDA:EC:2.3.1.20 , ENZYME:EC:2.3.1.20 , IUBMB-ExplorEnz:EC:2.3.1.20 , UniProt:RELATED-TO:Q9SLD2


References

Coleman76: Coleman R, Bell RM (1976). "Triacylglycerol synthesis in isolated fat cells. Studies on the microsomal diacylglycerol acyltransferase activity using ethanol-dispersed diacylglycerols." J Biol Chem 251(15);4537-43. PMID: 947894

Grigor82: Grigor MR, Bell RM (1982). "Separate monoacylglycerol and diacylglycerol acyltransferases function in intestinal triacylglycerol synthesis." Biochim Biophys Acta 712(3);464-72. PMID: 6289909

Kawasaki88: Kawasaki T, Snyder F (1988). "Synthesis of a novel acetylated neutral lipid related to platelet-activating factor by acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol acyltransferase in HL-60 cells." J Biol Chem 263(6);2593-6. PMID: 3422635

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

WEISS60: WEISS SB, KENNEDY EP, KIYASU JY (1960). "The enzymatic synthesis of triglycerides." J Biol Chem 235;40-4. PMID: 13843753


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Thu Nov 27, 2014, BIOCYC13A.