|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.168
Enzymes and Genes:
|Acinetobacter sp. ADP1:||wax ester synthase/acyl-CoA diacylglycerol acyltransferase bifunctional enzyme: atfA|
|Arabidopsis thaliana col:||acyl-CoA:diacylglycerol acyltransferase: TAG1|
|Petunia x hybrida:||wax synthase/diacyglycerol acyltransferase [multifunctional]: WS1|
|Saccharomyces cerevisiae:||acyl-CoA:diacylglycerol acyltransferase: DGA1|
In Pathway: diacylglycerol and triacylglycerol biosynthesis
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.
Mass balance status: Balanced.
Enzyme Commission Primary Name: diacylglycerol O-acyltransferase
Enzyme Commission Synonyms: diglyceride acyltransferase, 1,2-diacylglycerol acyltransferase, diacylglycerol acyltransferase, diglyceride O-acyltransferase, palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase, acyl-CoA:1,2-diacylglycerol O-acyltransferase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): 325.0658 [Latendresse13]
Enzyme Commission Summary:
Palmitoyl-CoA and other long-chain acyl-CoAs can act as donors.
Coleman76: Coleman R, Bell RM (1976). "Triacylglycerol synthesis in isolated fat cells. Studies on the microsomal diacylglycerol acyltransferase activity using ethanol-dispersed diacylglycerols." J Biol Chem 251(15);4537-43. PMID: 947894
Grigor82: Grigor MR, Bell RM (1982). "Separate monoacylglycerol and diacylglycerol acyltransferases function in intestinal triacylglycerol synthesis." Biochim Biophys Acta 712(3);464-72. PMID: 6289909
Kawasaki88: Kawasaki T, Snyder F (1988). "Synthesis of a novel acetylated neutral lipid related to platelet-activating factor by acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol acyltransferase in HL-60 cells." J Biol Chem 263(6);2593-6. PMID: 3422635
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