|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 220.127.116.11
Enzymes and Genes:
acyl-CoA:diacylglycerol acyltransferase : DGA1 ( Saccharomyces cerevisiae )
wax ester synthase/acyl-CoA diacylglycerol acyltransferase bifunctional enzyme : atfA ( Acinetobacter sp. ADP1 )
wax synthase/diacyglycerol acyltransferase [multifunctional] : WS1 ( Petunia x hybrida )
acyl-CoA:diacylglycerol acyltransferase : TAG1 ( Arabidopsis thaliana col )
In Pathway: triacylglycerol biosynthesis
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Mass balance status: Balanced.
Enzyme Commission Primary Name: diacylglycerol O-acyltransferase
Enzyme Commission Synonyms: diglyceride acyltransferase, 1,2-diacylglycerol acyltransferase, diacylglycerol acyltransferase, diglyceride O-acyltransferase, palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase, acyl-CoA:1,2-diacylglycerol O-acyltransferase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): 325.0658 [Latendresse13]
Enzyme Commission Summary:
Palmitoyl-CoA and other long-chain acyl-CoAs can act as donors.
Coleman76: Coleman R, Bell RM (1976). "Triacylglycerol synthesis in isolated fat cells. Studies on the microsomal diacylglycerol acyltransferase activity using ethanol-dispersed diacylglycerols." J Biol Chem 251(15);4537-43. PMID: 947894
Grigor82: Grigor MR, Bell RM (1982). "Separate monoacylglycerol and diacylglycerol acyltransferases function in intestinal triacylglycerol synthesis." Biochim Biophys Acta 712(3);464-72. PMID: 6289909
Kawasaki88: Kawasaki T, Snyder F (1988). "Synthesis of a novel acetylated neutral lipid related to platelet-activating factor by acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol acyltransferase in HL-60 cells." J Biol Chem 263(6);2593-6. PMID: 3422635
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