MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:

Acinetobacter sp. ADP1 : wax ester synthase/acyl-CoA diacylglycerol acyltransferase bifunctional enzyme Inferred from experiment : atfA
Arabidopsis thaliana col : acyl-CoA:diacylglycerol acyltransferase Inferred from experiment : TAG1
Petunia x hybrida : wax synthase/diacyglycerol acyltransferase [multifunctional] Inferred from experiment : WS1
Saccharomyces cerevisiae : acyl-CoA:diacylglycerol acyltransferase Inferred from experiment : DGA1

In Pathway: diacylglycerol and triacylglycerol biosynthesis

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: diacylglycerol O-acyltransferase

Enzyme Commission Synonyms: diglyceride acyltransferase, 1,2-diacylglycerol acyltransferase, diacylglycerol acyltransferase, diglyceride O-acyltransferase, palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase, acyl-CoA:1,2-diacylglycerol O-acyltransferase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 325.0658 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Palmitoyl-CoA and other long-chain acyl-CoAs can act as donors.

Citations: [Kawasaki88, Grigor82, Coleman76, WEISS60]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: KEGG:R02251 , Rhea:10868

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC: , UniProt:RELATED-TO:Q9SLD2


Coleman76: Coleman R, Bell RM (1976). "Triacylglycerol synthesis in isolated fat cells. Studies on the microsomal diacylglycerol acyltransferase activity using ethanol-dispersed diacylglycerols." J Biol Chem 251(15);4537-43. PMID: 947894

Grigor82: Grigor MR, Bell RM (1982). "Separate monoacylglycerol and diacylglycerol acyltransferases function in intestinal triacylglycerol synthesis." Biochim Biophys Acta 712(3);464-72. PMID: 6289909

Kawasaki88: Kawasaki T, Snyder F (1988). "Synthesis of a novel acetylated neutral lipid related to platelet-activating factor by acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol acyltransferase in HL-60 cells." J Biol Chem 263(6);2593-6. PMID: 3422635

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

WEISS60: WEISS SB, KENNEDY EP, KIYASU JY (1960). "The enzymatic synthesis of triglycerides." J Biol Chem 235;40-4. PMID: 13843753

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Sun Oct 4, 2015, BIOCYC14A.