Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 1.8.5.3

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Composite Reactions Electron-Transfer-Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.8.5.3

Enzymes and Genes:
dimethyl sulfoxide reductase Inferred from experiment : dmsA , dmsB , dmsC ( Escherichia coli K-12 substr. MG1655 )

In Pathway: formate to dimethyl sulfoxide electron transfer , NADH to dimethyl sulfoxide electron transfer

Reaction Locations: inner membrane (sensu Gram-negative Bacteria)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: dimethylsulfoxide reductase

Enzyme Commission Synonyms: DMSO reductase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 25.12525 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Contains molybdopterin and [4Fe-4S] clusters. Also reduces pyridine N-oxide and trimethylamine N-oxide, with lower activity, to the corresponding amines.

Citations: [SimalaGrant96, Daruwala91, Rothery99a]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:1.8.5.3 , ENZYME:EC:1.8.5.3 , IUBMB-ExplorEnz:EC:1.8.5.3

Credits:
Revised 14-Mar-2011 by Caspi R , SRI International


References

Daruwala91: Daruwala R, Meganathan R (1991). "Dimethyl sulfoxide reductase is not required for trimethylamine N-oxide reduction in Escherichia coli." FEMS Microbiol Lett 67(3);255-9. PMID: 1769531

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Rothery99a: Rothery RA, Trieber CA, Weiner JH (1999). "Interactions between the molybdenum cofactor and iron-sulfur clusters of Escherichia coli dimethylsulfoxide reductase." J Biol Chem 274(19);13002-9. PMID: 10224050

SimalaGrant96: Simala-Grant JL, Weiner JH (1996). "Kinetic analysis and substrate specificity of Escherichia coli dimethyl sulfoxide reductase." Microbiology 142 ( Pt 11);3231-9. PMID: 8969520


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sat Nov 22, 2014, BIOCYC13B.