MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical ReactionsComposite ReactionsElectron-Transfer-Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Escherichia coli K-12 substr. MG1655: dimethyl sulfoxide reductaseInferred from experiment: dmsA, dmsB, dmsC

In Pathway: formate to dimethyl sulfoxide electron transfer, NADH to dimethyl sulfoxide electron transfer, hydrogen to dimethyl sulfoxide electron transfer

Transport reaction diagram

Reaction Locations: inner membrane (sensu Gram-negative Bacteria)

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: dimethylsulfoxide reductase

Enzyme Commission Synonyms: DMSO reductase

Standard Gibbs Free Energy (ΔrG): -25.12525 kcal/molInferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Contains molybdopterin and [4Fe-4S] clusters. Also reduces pyridine N-oxide and trimethylamine N-oxide, with lower activity, to the corresponding amines.

Citations: [SimalaGrant96, Daruwala91, Rothery99a]

Gene-Reaction Schematic

Gene-Reaction Schematic

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:

Revised 14-Mar-2011 by Caspi R, SRI International


Daruwala91: Daruwala R, Meganathan R (1991). "Dimethyl sulfoxide reductase is not required for trimethylamine N-oxide reduction in Escherichia coli." FEMS Microbiol Lett 67(3);255-9. PMID: 1769531

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Rothery99a: Rothery RA, Trieber CA, Weiner JH (1999). "Interactions between the molybdenum cofactor and iron-sulfur clusters of Escherichia coli dimethylsulfoxide reductase." J Biol Chem 274(19);13002-9. PMID: 10224050

SimalaGrant96: Simala-Grant JL, Weiner JH (1996). "Kinetic analysis and substrate specificity of Escherichia coli dimethyl sulfoxide reductase." Microbiology 142 ( Pt 11);3231-9. PMID: 8969520

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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