MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:

Arabidopsis thaliana col : nucleoside-diphosphate kinase 1 Inferred from experiment : NDPK1
Escherichia coli K-12 substr. MG1655 : nucleoside diphosphate kinase Inferred from experiment : ndk
Halobacterium salinarum : nucleoside-diphosphate kinase Inferred from experiment : ndk
Homo sapiens : nucleoside diphosphate kinase Traceable author statement to experimental support : NME1 , NME2
Saccharomyces cerevisiae : nucleoside diphosphate kinase Inferred from experiment : YNK1

In Pathway: pyrimidine deoxyribonucleotides de novo biosynthesis II , superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli) , pyrimidine deoxyribonucleotides de novo biosynthesis III , pyrimidine deoxyribonucleotides de novo biosynthesis I , pyrimidine deoxyribonucleotides de novo biosynthesis IV , pyrimidine deoxyribonucleotide phosphorylation , pyrimidine deoxyribonucleotides biosynthesis from CTP

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: nucleoside-diphosphate kinase

Enzyme Commission Synonyms: nucleoside 5'-diphosphate kinase, nucleoside diphosphate (UDP) kinase, nucleoside diphosphokinase, nucleotide phosphate kinase, UDP kinase, uridine diphosphate kinase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 94.98999 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Many nucleoside diphosphates can act as acceptors, while many ribo- and deoxyribonucleoside triphosphates can act as donors.

Citations: [Berg54, Ayengar56, Kirkland59, Krebs53, Nakamura66, Ratliff64]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Instance reactions of [a nucleoside diphosphate + ATP → a nucleoside triphosphate + ADP] (
i1: ATP + dIDP = ADP + dITP (

i2: dADP + ATP → dATP + ADP (

i3: dGDP + ATP → dGTP + ADP (

i4: dCDP + ATP → dCTP + ADP (

i5: GDP + ATP → GTP + ADP (

i6: dUDP + ATP → dUTP + ADP (

i7: ATP + IDP = ITP + ADP (

i8: dTDP + ATP → dTTP + ADP (
i9: UDP + ATP → UTP + ADP (

i10: CDP + ATP → CTP + ADP (

Unification Links: KEGG:R02093 , Rhea:27682

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:


Ayengar56: Ayengar P, Gibson DM, Sanadi DR (1956). "Transphosphorylations between nucleoside phosphates." Biochim Biophys Acta 21(1);86-91. PMID: 13363863

Berg54: Berg P, Joklik WK (1954). "Enzymatic phosphorylation of nucleoside diphosphates." J Biol Chem 210(2);657-72. PMID: 13211603

Kirkland59: Kirkland RJ, Turner JF (1959). "Nucleoside diphosphokinase of pea seeds." Biochem J 72;716-20. PMID: 14409347

Krebs53: Krebs HA, Hems R (1953). "Some reactions of adenosine and inosine phosphates in animal tissues." Biochim Biophys Acta 12(1-2);172-80. PMID: 13115426

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Nakamura66: Nakamura H, Sugino Y (1966). "Metabolism of deoxyribonucleotides. 3. Purification and some properties of nucleoside diphosphokinase of calf thymus." J Biol Chem 241(21);4917-22. PMID: 5925862

Ratliff64: Ratliff RL, Weaver RH, LardyHA, Kuby SA (1964). "Nucleoside triphosphate-nucleoside diphosphate transphosphorylase (nucleoside diphosphokinase). I. Isolation of the crystalline enzyme from brewers' yeast." J Biol Chem 239;301-9. PMID: 14114857

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Thu Oct 8, 2015, biocyc13.