|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 220.127.116.11
Enzymes and Genes:
|Arabidopsis thaliana col:||nucleoside-diphosphate kinase 1: NDPK1|
|Escherichia coli K-12 substr. MG1655:||nucleoside diphosphate kinase: ndk|
|Halobacterium salinarum:||nucleoside-diphosphate kinase: ndk|
|Homo sapiens:||nucleoside diphosphate kinase: NME1, NME2|
|Saccharomyces cerevisiae:||nucleoside diphosphate kinase: YNK1|
In Pathway: pyrimidine deoxyribonucleotides de novo biosynthesis II, superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli), pyrimidine deoxyribonucleotides de novo biosynthesis III, pyrimidine deoxyribonucleotides de novo biosynthesis I, pyrimidine deoxyribonucleotides de novo biosynthesis IV, pyrimidine deoxyribonucleotide phosphorylation, pyrimidine deoxyribonucleotides biosynthesis from CTP
Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.
Mass balance status: Balanced.
Enzyme Commission Primary Name: nucleoside-diphosphate kinase
Enzyme Commission Synonyms: nucleoside 5'-diphosphate kinase, nucleoside diphosphate (UDP) kinase, nucleoside diphosphokinase, nucleotide phosphate kinase, UDP kinase, uridine diphosphate kinase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): 94.98999 [Latendresse13]
Enzyme Commission Summary:
Many nucleoside diphosphates can act as acceptors, while many ribo- and deoxyribonucleoside triphosphates can act as donors.
Instance reactions of [a nucleoside diphosphate + ATP → a nucleoside triphosphate + ADP] (18.104.22.168):
i1: dGDP + ATP → dGTP + ADP (22.214.171.124)
i2: dTDP + ATP → dTTP + ADP (126.96.36.199)
i3: CDP + ATP → CTP + ADP (188.8.131.52)
i4: ATP + IDP = ITP + ADP (184.108.40.206)
i5: dADP + ATP → dATP + ADP (220.127.116.11)
i6: dUDP + ATP → dUTP + ADP (18.104.22.168)
i7: ATP + dIDP = ADP + dITP (22.214.171.124)
i8: dCDP + ATP → dCTP + ADP (126.96.36.199)
i9: GDP + ATP → GTP + ADP (188.8.131.52)
i10: UDP + ATP → UTP + ADP (184.108.40.206)
Nakamura66: Nakamura H, Sugino Y (1966). "Metabolism of deoxyribonucleotides. 3. Purification and some properties of nucleoside diphosphokinase of calf thymus." J Biol Chem 241(21);4917-22. PMID: 5925862
Ratliff64: Ratliff RL, Weaver RH, LardyHA, Kuby SA (1964). "Nucleoside triphosphate-nucleoside diphosphate transphosphorylase (nucleoside diphosphokinase). I. Isolation of the crystalline enzyme from brewers' yeast." J Biol Chem 239;301-9. PMID: 14114857
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