|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 188.8.131.52
Enzymes and Genes:
1-deoxyxylulose-5-phosphate synthase : dxs ( Escherichia coli K-12 substr. MG1655 )
1-deoxyxylulose-5-phosphate synthase : dxs ( Bacillus subtilis subtilis 168 )
1-deoxy-D-xylulose-5-phosphate synthase : dxs ( Croton stellatopilosus )
1-deoxy-D-xylulose 5-phosphate synthase : CLA1 ( Arabidopsis thaliana col )
In Pathway: pyridoxal 5'-phosphate biosynthesis I , thiazole biosynthesis II (Bacillus) , thiazole biosynthesis I (E. coli) , methylerythritol phosphate pathway II , methylerythritol phosphate pathway I
Supersedes EC number: 184.108.40.206
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: 1-deoxy-D-xylulose-5-phosphate synthase
Enzyme Commission Synonyms: 1-deoxy-D-xylulose-5-phosphate pyruvate-lyase (carboxylating), DXP-synthase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -10.71582 [Latendresse13]
Enzyme Commission Summary:
Kuzuyama00a: Kuzuyama T, Takagi M, Takahashi S, Seto H (2000). "Cloning and characterization of 1-deoxy-D-xylulose 5-phosphate synthase from Streptomyces sp. Strain CL190, which uses both the mevalonate and nonmevalonate pathways for isopentenyl diphosphate biosynthesis." J Bacteriol 182(4);891-7. PMID: 10648511
Sprenger97: Sprenger GA, Schorken U, Wiegert T, Grolle S, de Graaf AA, Taylor SV, Begley TP, Bringer-Meyer S, Sahm H (1997). "Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-D-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol." Proc Natl Acad Sci U S A 1997;94(24);12857-62. PMID: 9371765
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