Metabolic Modeling Tutorial
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BioCyc websites down
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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MetaCyc Reaction: 2.2.1.7

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.2.1.7

Enzymes and Genes:
1-deoxyxylulose-5-phosphate synthase Inferred from experiment : dxs ( Escherichia coli K-12 substr. MG1655 )
1-deoxyxylulose-5-phosphate synthase Inferred from experiment : dxs ( Bacillus subtilis subtilis 168 )
1-deoxy-D-xylulose-5-phosphate synthase Inferred from experiment : dxs ( Croton stellatopilosus )
1-deoxy-D-xylulose 5-phosphate synthase Inferred from experiment : CLA1 ( Arabidopsis thaliana col )

In Pathway: pyridoxal 5'-phosphate biosynthesis I , thiazole biosynthesis II (Bacillus) , thiazole biosynthesis I (E. coli) , methylerythritol phosphate pathway II , methylerythritol phosphate pathway I

Supersedes EC number: 4.1.3.37

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 1-deoxy-D-xylulose-5-phosphate synthase

Enzyme Commission Synonyms: 1-deoxy-D-xylulose-5-phosphate pyruvate-lyase (carboxylating), DXP-synthase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -10.71582 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Formerly 4.1.3.37

Citations: [Kuzuyama00a, Sprenger97]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R05636 , Rhea:12605

Relationship Links: BRENDA:EC:2.2.1.7 , ENZYME:EC:2.2.1.7 , IUBMB-ExplorEnz:EC:2.2.1.7


References

Kuzuyama00a: Kuzuyama T, Takagi M, Takahashi S, Seto H (2000). "Cloning and characterization of 1-deoxy-D-xylulose 5-phosphate synthase from Streptomyces sp. Strain CL190, which uses both the mevalonate and nonmevalonate pathways for isopentenyl diphosphate biosynthesis." J Bacteriol 182(4);891-7. PMID: 10648511

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Sprenger97: Sprenger GA, Schorken U, Wiegert T, Grolle S, de Graaf AA, Taylor SV, Begley TP, Bringer-Meyer S, Sahm H (1997). "Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-D-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol." Proc Natl Acad Sci U S A 1997;94(24);12857-62. PMID: 9371765


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sun Dec 21, 2014, biocyc14.