Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 2.2.1.7

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.2.1.7

Enzymes and Genes:
1-deoxyxylulose-5-phosphate synthase Inferred from experiment : dxs ( Escherichia coli K-12 substr. MG1655 )
1-deoxyxylulose-5-phosphate synthase Inferred from experiment : dxs ( Bacillus subtilis subtilis 168 )
1-deoxy-D-xylulose-5-phosphate synthase Inferred from experiment : dxs ( Croton stellatopilosus )
1-deoxy-D-xylulose 5-phosphate synthase Inferred from experiment : CLA1 ( Arabidopsis thaliana col )

In Pathway: pyridoxal 5'-phosphate biosynthesis I , thiazole biosynthesis II (Bacillus) , thiazole biosynthesis I (E. coli) , methylerythritol phosphate pathway II , methylerythritol phosphate pathway I

Supersedes EC number: 4.1.3.37

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 1-deoxy-D-xylulose-5-phosphate synthase

Enzyme Commission Synonyms: 1-deoxy-D-xylulose-5-phosphate pyruvate-lyase (carboxylating), DXP-synthase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -10.71582 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Formerly 4.1.3.37

Citations: [Kuzuyama00, Sprenger97]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R05636 , Rhea:12605

Relationship Links: BRENDA:EC:2.2.1.7 , ENZYME:EC:2.2.1.7 , IUBMB-ExplorEnz:EC:2.2.1.7


References

Kuzuyama00: Kuzuyama T, Takagi M, Takahashi S, Seto H (2000). "Cloning and characterization of 1-deoxy-D-xylulose 5-phosphate synthase from Streptomyces sp. Strain CL190, which uses both the mevalonate and nonmevalonate pathways for isopentenyl diphosphate biosynthesis." J Bacteriol 182(4);891-7. PMID: 10648511

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Sprenger97: Sprenger GA, Schorken U, Wiegert T, Grolle S, de Graaf AA, Taylor SV, Begley TP, Bringer-Meyer S, Sahm H (1997). "Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-D-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol." Proc Natl Acad Sci U S A 1997;94(24);12857-62. PMID: 9371765


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sat Nov 22, 2014, BIOCYC13B.