MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Arabidopsis thaliana col: 1-deoxy-D-xylulose 5-phosphate synthaseInferred from experiment: CLA1
Bacillus subtilis subtilis 168: 1-deoxyxylulose-5-phosphate synthaseInferred from experiment: dxs
Croton stellatopilosus: 1-deoxy-D-xylulose-5-phosphate synthaseInferred from experiment: dxs
Escherichia coli K-12 substr. MG1655: 1-deoxyxylulose-5-phosphate synthaseInferred from experiment: dxs

In Pathway: pyridoxal 5'-phosphate biosynthesis I, thiazole biosynthesis II (aerobic bacteria), thiazole biosynthesis I (facultative anaerobic bacteria), methylerythritol phosphate pathway II, methylerythritol phosphate pathway I

Supersedes EC number:

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 1-deoxy-D-xylulose-5-phosphate synthase

Enzyme Commission Synonyms: 1-deoxy-D-xylulose-5-phosphate pyruvate-lyase (carboxylating), DXP-synthase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -10.71582Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:

Citations: [Kuzuyama00, Sprenger97]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R05636, Rhea:12605

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Kuzuyama00: Kuzuyama T, Takagi M, Takahashi S, Seto H (2000). "Cloning and characterization of 1-deoxy-D-xylulose 5-phosphate synthase from Streptomyces sp. Strain CL190, which uses both the mevalonate and nonmevalonate pathways for isopentenyl diphosphate biosynthesis." J Bacteriol 182(4);891-7. PMID: 10648511

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Sprenger97: Sprenger GA, Schorken U, Wiegert T, Grolle S, de Graaf AA, Taylor SV, Begley TP, Bringer-Meyer S, Sahm H (1997). "Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-D-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol." Proc Natl Acad Sci U S A 1997;94(24);12857-62. PMID: 9371765

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.5 on Sun Nov 29, 2015, BIOCYC13B.