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MetaCyc Reaction: 2.3.1.85

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.3.1.85

Enzymes and Genes:

Homo sapiens : fatty acid synthase Inferred from experiment : FASN

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balance undetermined; a substrate has a non-numerical coefficient

Enzyme Commission Primary Name: fatty-acid synthase

Enzyme Commission Synonyms: FASN (gene name)

Taxonomic Range: Metazoa

Enzyme Commission Summary:
The animal enzyme is a multi-functional protein catalysing the reactions of EC 2.3.1.38, [acyl-carrier-protein] S-acetyltransferase, EC 2.3.1.39, [acyl-carrier-protein] S-malonyltransferase, EC 2.3.1.41, β-ketoacyl-[acyl-carrier-protein] synthase I, EC 1.1.1.100, 3-oxoacyl-[acyl-carrier-protein] reductase, EC 4.2.1.59, 3-hydroxyacyl-[acyl-carrier-protein] dehydratase, EC 1.3.1.39, enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) and EC 3.1.2.14, oleoyl-[acyl-carrier-protein] hydrolase. cf. EC 2.3.1.86, fatty-acyl-CoA synthase.

Citations: [Stoops79, Wakil83]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: KEGG:R05188

Relationship Links: BRENDA:EC:2.3.1.85 , ENZYME:EC:2.3.1.85 , IUBMB-ExplorEnz:EC:2.3.1.85 , UniProt:RELATED-TO:P07855 , UniProt:RELATED-TO:P08757 , UniProt:RELATED-TO:P12276 , UniProt:RELATED-TO:P12785 , UniProt:RELATED-TO:P15368 , UniProt:RELATED-TO:P19097 , UniProt:RELATED-TO:P36189 , UniProt:RELATED-TO:P43098 , UniProt:RELATED-TO:P49327 , UniProt:RELATED-TO:P78866 , UniProt:RELATED-TO:P95029 , UniProt:RELATED-TO:Q04846 , UniProt:RELATED-TO:Q10289 , UniProt:RELATED-TO:Q48926 , UniProt:RELATED-TO:Q59497

Credits:
Revised 12-Dec-2011 by Caspi R , SRI International


References

Stoops79: Stoops JK, Ross P, Arslanian MJ, Aune KC, Wakil SJ, Oliver RM (1979). "Physicochemical studies of the rat liver and adipose fatty acid synthetases." J Biol Chem 254(15);7418-26. PMID: 457689

Wakil83: Wakil SJ, Stoops JK, Joshi VC (1983). "Fatty acid synthesis and its regulation." Annu Rev Biochem 52;537-79. PMID: 6137188


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Sun Aug 30, 2015, BIOCYC14B.