Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 2.3.1.85

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.3.1.85

Enzymes and Genes:
fatty acid synthase Inferred from experiment : FASN ( Homo sapiens )

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Undetermined; a substrate has a non-numerical coefficient

Enzyme Commission Primary Name: fatty-acid synthase

Enzyme Commission Synonyms: FASN (gene name)

Enzyme Commission Summary:
The animal enzyme is a multi-functional protein catalysing the reactions of EC 2.3.1.38, [acyl-carrier-protein] S-acetyltransferase, EC 2.3.1.39, [acyl-carrier-protein] S-malonyltransferase, EC 2.3.1.41, β-ketoacyl-[acyl-carrier-protein] synthase I, EC 1.1.1.100, 3-oxoacyl-[acyl-carrier-protein] reductase, EC 4.2.1.59, 3-hydroxyacyl-[acyl-carrier-protein] dehydratase, EC 1.3.1.39, enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) and EC 3.1.2.14, oleoyl-[acyl-carrier-protein] hydrolase. cf. EC 2.3.1.86, fatty-acyl-CoA synthase.

Citations: [Stoops79, Wakil83]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R05188

Relationship Links: BRENDA:EC:2.3.1.85 , ENZYME:EC:2.3.1.85 , IUBMB-ExplorEnz:EC:2.3.1.85 , UniProt:RELATED-TO:P07855 , UniProt:RELATED-TO:P08757 , UniProt:RELATED-TO:P12276 , UniProt:RELATED-TO:P12785 , UniProt:RELATED-TO:P15368 , UniProt:RELATED-TO:P19097 , UniProt:RELATED-TO:P36189 , UniProt:RELATED-TO:P43098 , UniProt:RELATED-TO:P49327 , UniProt:RELATED-TO:P78866 , UniProt:RELATED-TO:P95029 , UniProt:RELATED-TO:Q04846 , UniProt:RELATED-TO:Q10289 , UniProt:RELATED-TO:Q48926 , UniProt:RELATED-TO:Q59497

Credits:
Revised 12-Dec-2011 by Caspi R , SRI International


References

Stoops79: Stoops JK, Ross P, Arslanian MJ, Aune KC, Wakil SJ, Oliver RM (1979). "Physicochemical studies of the rat liver and adipose fatty acid synthetases." J Biol Chem 254(15);7418-26. PMID: 457689

Wakil83: Wakil SJ, Stoops JK, Joshi VC (1983). "Fatty acid synthesis and its regulation." Annu Rev Biochem 52;537-79. PMID: 6137188


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Mon Nov 24, 2014, BIOCYC14B.