|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.168
In Pathway: fatty acids biosynthesis (yeast)
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Undetermined; a substrate has a non-numerical coefficient
Enzyme Commission Primary Name: fatty-acyl-CoA synthase
Enzyme Commission Synonyms: yeast fatty acid synthase, FAS1 (gene name), FAS2 (gene name)
Enzyme Commission Summary:
The enzyme from yeasts (Ascomycota and Basidiomycota) is a multi-functional protein complex composed of two subunits.One subunit catalyses the reactions EC 22.214.171.124, 3-oxoacyl-[acyl-carrier-protein] reductase and EC 126.96.36.199, β-ketoacyl-[acyl-carrier-protein] synthase I, while the other subunit catalyses the reactions of EC 188.8.131.52, [acyl-carrier-protein] S-acetyltransferase, EC 184.108.40.206, [acyl-carrier-protein] S-malonyltransferase, EC 220.127.116.11, 3-hydroxyacyl-[acyl-carrier-protein] dehydratase, EC 18.104.22.168, enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific) and EC 22.214.171.1249, (R)-3-hydroxyacid-ester dehydrogenase. The enzyme differs from the animal enzyme (EC 126.96.36.199) in that the enoyl reductase domain requires FMN as a cofactor, and the ultimate product is an acyl-CoA (usually palmitoyl-CoA) instead of a free fatty acid.
Unification Links: KEGG:R05190
Relationship Links: BRENDA:EC:188.8.131.52 , ENZYME:EC:184.108.40.206 , IUBMB-ExplorEnz:EC:220.127.116.11 , UniProt:RELATED-TO:P07149 , UniProt:RELATED-TO:P34229 , UniProt:RELATED-TO:P34731 , UniProt:RELATED-TO:Q9UUG0
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