MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Arabidopsis thaliana col: ferric chelate reductaseInferred from experiment: FRO2
Cryptococcus albidus IFO 0939: NADH:Fe(III)EDTA oxidoreductaseInferred from experiment
Oryza sativa: ferric chelate reductaseInferred by computational analysisInferred from experiment: OsFRO1
ferric chelate reductaseInferred by computational analysisInferred from experiment: OsFRO2

In Pathway: iron reduction and absorption, ethylene biosynthesis III (microbes)

Supersedes EC number:

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: ferric-chelate reductase (NADH)

Enzyme Commission Synonyms: ferric chelate reductase (ambiguous), iron chelate reductase (ambiguous), NADH:Fe3+-EDTA reductase, NADH2:Fe3+ oxidoreductase, ferB (gene name), Fe(II):NAD+ oxidoreductase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 10.873596Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Contains FAD. The enzyme catalyses the reduction of bound ferric iron in a variety of iron chelators (siderophores), resulting in the release of ferrous iron. The plant enzyme is Involved in the transport of iron across plant plasma membranes. The enzyme from the bacterium Paracoccus denitrificans can also reduce chromate. cf. EC, ferric-chelate reductase (NADPH) and EC, ferric-chelate reductase [NAD(P)H].

Citations: [Mazoch04, Askerlund88, Bruggemann89, Bruggemann90, Buckhout86, Sandelius86]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R00092, Rhea:15061

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Askerlund88: Askerlund P, Larsson C, Widell S (1988). "Localization of donor and acceptor sites of NADH dehydrogenase activities using inside-out and right-side-out plasma membrane vesicles from plants." FEBS Letters 239(1);23-28.

Bruggemann89: Bruggemann W, Moog PR (1989). "NADH-dependent Fe3+EDTA and oxygen reduction by plasma membrane vesicles from barley roots." Physiologia Plantarum 75(2);245-254.

Bruggemann90: Bruggemann W, Moog PR, Nakagawa H, Janiesch P, Kuiper PJ C (1990). "Plasma membrane-bound NADH: Fe3+-EDTA reductase and iron deficiency in tomato (Lycopersicon esculentum). Is there a Turbo reductase?." Physiologia Plantarum 79(2);339-346.

Buckhout86: Buckhout T J, Hrubec TC (1986). "Pyridine nucleotide-dependent ferricyanide reduction associated with isolated plasma membranes of maize (Zea mays L.) roots." Protoplasma 135(2-3);144-154.

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Mazoch04: Mazoch J, Tesarik R, Sedlacek V, Kucera I, Turanek J (2004). "Isolation and biochemical characterization of two soluble iron(III) reductases from Paracoccus denitrificans." Eur J Biochem 271(3);553-62. PMID: 14728682

Sandelius86: Sandelius AS, Barr R, Crane FL, Morre DJ (1986). "Redox reactions of plasma membranes isolated from soybean hypocotyls by phase partition." Plant Sci. 48: 1-10.

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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