Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 1.16.1.7

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.16.1.7

Enzymes and Genes:
NADH:Fe(III)EDTA oxidoreductase Inferred from experiment ( Cryptococcus albidus IFO 0939 )
ferric chelate reductase Inferred from experiment : FRO2 ( Arabidopsis thaliana col )
ferric chelate reductase Inferred by computational analysis Inferred from experiment : OsFRO2 ( Oryza sativa )
ferric chelate reductase Inferred by computational analysis Inferred from experiment : OsFRO1 ( Oryza sativa )

In Pathway: iron reduction and absorption , ethylene biosynthesis III (microbes)

Supersedes EC number: 1.6.99.13

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: ferric-chelate reductase (NADH)

Enzyme Commission Synonyms: ferric chelate reductase (ambiguous), iron chelate reductase (ambiguous), NADH:Fe3+-EDTA reductase, NADH2:Fe3+ oxidoreductase, ferB (gene name), Fe(II):NAD+ oxidoreductase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 9.625336 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Contains FAD. The enzyme catalyses the reduction of bound ferric iron in a variety of iron chelators (siderophores), resulting in the release of ferrous iron. The plant enzyme is Involved in the transport of iron across plant plasma membranes. The enzyme from the bacterium Paracoccus denitrificans can also reduce chromate. cf. EC 1.16.1.9, ferric-chelate reductase (NADPH) and EC 1.16.1.10, ferric-chelate reductase [NAD(P)H].

Citations: [Mazoch04, Askerlund88, Bruggemann89, Bruggemann90, Buckhout86, Sandelius86]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R00092 , Rhea:15061

Relationship Links: BRENDA:EC:1.16.1.7 , ENZYME:EC:1.16.1.7 , IUBMB-ExplorEnz:EC:1.16.1.7


References

Askerlund88: Askerlund P, Larsson C, Widell S (1988). "Localization of donor and acceptor sites of NADH dehydrogenase activities using inside-out and right-side-out plasma membrane vesicles from plants." FEBS Letters 239(1);23-28.

Bruggemann89: Bruggemann W, Moog PR (1989). "NADH-dependent Fe3+EDTA and oxygen reduction by plasma membrane vesicles from barley roots." Physiologia Plantarum 75(2);245-254.

Bruggemann90: Bruggemann W, Moog PR, Nakagawa H, Janiesch P, Kuiper PJ C (1990). "Plasma membrane-bound NADH: Fe3+-EDTA reductase and iron deficiency in tomato (Lycopersicon esculentum). Is there a Turbo reductase?." Physiologia Plantarum 79(2);339-346.

Buckhout86: Buckhout T J, Hrubec TC (1986). "Pyridine nucleotide-dependent ferricyanide reduction associated with isolated plasma membranes of maize (Zea mays L.) roots." Protoplasma 135(2-3);144-154.

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Mazoch04: Mazoch J, Tesarik R, Sedlacek V, Kucera I, Turanek J (2004). "Isolation and biochemical characterization of two soluble iron(III) reductases from Paracoccus denitrificans." Eur J Biochem 271(3);553-62. PMID: 14728682

Sandelius86: Sandelius AS, Barr R, Crane FL, Morre DJ (1986). "Redox reactions of plasma membranes isolated from soybean hypocotyls by phase partition." Plant Sci. 48: 1-10.


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sat Nov 22, 2014, biocyc14.