|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 220.127.116.11
Enzymes and Genes:
NADH:Fe(III)EDTA oxidoreductase ( Cryptococcus albidus IFO 0939 )
ferric chelate reductase : FRO2 ( Arabidopsis thaliana col )
ferric chelate reductase : OsFRO2 ( Oryza sativa )
ferric chelate reductase : OsFRO1 ( Oryza sativa )
Supersedes EC number: 18.104.22.168
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: ferric-chelate reductase (NADH)
Enzyme Commission Synonyms: ferric chelate reductase (ambiguous), iron chelate reductase (ambiguous), NADH:Fe3+-EDTA reductase, NADH2:Fe3+ oxidoreductase, ferB (gene name), Fe(II):NAD+ oxidoreductase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): 10.873596 [Latendresse13]
Enzyme Commission Summary:
Contains FAD. The enzyme catalyses the reduction of bound ferric iron in a variety of iron chelators (siderophores), resulting in the release of ferrous iron. The plant enzyme is Involved in the transport of iron across plant plasma membranes. The enzyme from the bacterium Paracoccus denitrificans can also reduce chromate. cf. EC 22.214.171.124, ferric-chelate reductase (NADPH) and EC 126.96.36.199, ferric-chelate reductase [NAD(P)H].
Askerlund88: Askerlund P, Larsson C, Widell S (1988). "Localization of donor and acceptor sites of NADH dehydrogenase activities using inside-out and right-side-out plasma membrane vesicles from plants." FEBS Letters 239(1);23-28.
Bruggemann90: Bruggemann W, Moog PR, Nakagawa H, Janiesch P, Kuiper PJ C (1990). "Plasma membrane-bound NADH: Fe3+-EDTA reductase and iron deficiency in tomato (Lycopersicon esculentum). Is there a Turbo reductase?." Physiologia Plantarum 79(2);339-346.
Buckhout86: Buckhout T J, Hrubec TC (1986). "Pyridine nucleotide-dependent ferricyanide reduction associated with isolated plasma membranes of maize (Zea mays L.) roots." Protoplasma 135(2-3);144-154.
Mazoch04: Mazoch J, Tesarik R, Sedlacek V, Kucera I, Turanek J (2004). "Isolation and biochemical characterization of two soluble iron(III) reductases from Paracoccus denitrificans." Eur J Biochem 271(3);553-62. PMID: 14728682
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