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MetaCyc Reaction: 1.2.1.46

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.2.1.46

Enzymes and Genes:

Corynebacterium glutamicum ATCC 13032 : acetaldehyde dehydrogenase Inferred from experiment : ald
Pseudomonas putida : formaldehyde dehydrogenase Inferred from experiment : fdhA

In Pathway: formaldehyde oxidation IV (thiol-independent) , methanol oxidation to carbon dioxide

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: formaldehyde dehydrogenase

Enzyme Commission Synonyms: NAD-linked formaldehyde dehydrogenase, NAD-dependent formaldehyde dehydrogenase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -13.095337 Inferred by computational analysis [Latendresse13]

Citations: [Hohnloser80]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Instance reactions of [an aldehyde + NAD+ + H2O → a carboxylate + NADH + 2 H+] (1.2.1.3):
i1: phytenal + NAD+ + H2O → phytenate + NADH + 2 H+ (1.2.1.3)

i2: methylglyoxal + NAD+ + H2O → pyruvate + NADH + 2 H+ (1.2.1.23)

i3: (R)-lactaldehyde + NAD+ + H2O → (R)-lactate + NADH + 2 H+ (no EC#)

i4: (S)-lactaldehyde + NAD+ + H2O → (S)-lactate + NADH + 2 H+ (1.2.1.22)

i5: salicylaldehyde + NAD+ + H2O → salicylate + NADH + 2 H+ (1.2.1.65)

i6: acetaldehyde + NAD+ + H2O → acetate + NADH + 2 H+ (1.2.1.3)

i7: octanal + NAD+ + H2O → octanoate + NADH + 2 H+ (1.2.1.3)

i8: fluoroacetaldehyde + NAD+ + H2O → fluoroacetate + NADH + 2 H+ (1.2.1.69)

i9: benzaldehyde + NAD+ + H2O ↔ benzoate + NADH + 2 H+ (1.2.1.28)

i10: 4-methylbenzaldehyde + NAD+ + H2O → 4-toluenecarboxylate + NADH + 2 H+ (no EC#)

i11: dodecanal + NAD+ + H2O = laurate + NADH + 2 H+ (1.2.1.3)

i12: decanal + NAD+ + H2O = decanoate + NADH + 2 H+ (1.2.1.3)

i13: all-trans-retinal + NAD+ + H2O = all-trans-retinoate + NADH + 2 H+ (1.2.1.36)

i14: a fatty aldehyde + NAD+ + H2O → a fatty acid + NADH + 2 H+ (1.2.1.3)

i15: a long-chain aldehyde + NAD+ + H2O = a long-chain fatty acid + NADH + 2 H+ (1.2.1.48)

i16: a 2-methyl branched 2,3,4-saturated fatty aldehyde + NAD+ + H2O → a 2-methyl branched 2,3,4-saturated fatty acid + NADH + 2 H+ (1.2.1.3)

i17: an odd numbered straight chain 2,3,4-saturated fatty aldehyde + NAD+ + H2O → an odd numbered straight chain 2,3,4-saturated fatty acid + NADH + 2 H+ (1.2.1.3)

Unification Links: KEGG:R00604 , Rhea:16425

Relationship Links: BRENDA:EC:1.2.1.46 , ENZYME:EC:1.2.1.46 , IUBMB-ExplorEnz:EC:1.2.1.46 , UniProt:RELATED-TO:P46154 , UniProt:RELATED-TO:Q45604


References

Hohnloser80: Hohnloser W, Osswald B, Lingens F (1980). "Enzymological aspects of caffeine demethylation and formaldehyde oxidation by Pseudomonas putida C1." Hoppe Seylers Z Physiol Chem 361(12);1763-6. PMID: 7461603

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Sat Sep 5, 2015, biocyc11.