MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Corynebacterium glutamicum ATCC 13032: acetaldehyde dehydrogenaseInferred from experiment: ald
Homo sapiens: 4-trimethylaminobutyraldehyde dehydrogenase: ALDH9A1
fatty aldehyde dehydrogenase: ALDH3A2
mitochondrial aldehyde dehydrogenase: ALDH2
Pseudomonas oleovorans: aldehyde dehydrogenase: alkH
Pseudomonas putida: formaldehyde dehydrogenaseInferred from experiment: fdhA
Saccharomyces cerevisiae: aldehyde dehydrogenase: ALD3
aldehyde dehydrogenase: ALD2
potassium-activated aldehyde dehydrogenase, mitochondrial: ALD4
aldehyde dehydrogenase, mitochondrial: ALD5

In Pathway: formaldehyde oxidation IV (thiol-independent), methanol oxidation to carbon dioxide

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: formaldehyde dehydrogenase

Enzyme Commission Synonyms: NAD-linked formaldehyde dehydrogenase, NAD-dependent formaldehyde dehydrogenase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -13.095337Inferred by computational analysis [Latendresse13]

Citations: [Hohnloser80]

Gene-Reaction Schematic

Gene-Reaction Schematic

Instance reaction of [an aldehyde + NAD+ + H2O → a carboxylate + NADH + 2 H+] (
i1: formaldehyde + NAD+ + H2O → formate + NADH + 2 H+ (

Unification Links: KEGG:R00604, Rhea:16425

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, UniProt:RELATED-TO:P46154, UniProt:RELATED-TO:Q45604


Hohnloser80: Hohnloser W, Osswald B, Lingens F (1980). "Enzymological aspects of caffeine demethylation and formaldehyde oxidation by Pseudomonas putida C1." Hoppe Seylers Z Physiol Chem 361(12);1763-6. PMID: 7461603

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Tue Dec 1, 2015, biocyc13.