Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 6.3.4.3

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 6.3.4.3

Enzymes and Genes:
formate--tetrahydrofolate ligase Inferred from experiment : fhs ( Clostridium cylindrosporum )
formyltetrahydrofolate synthetase Inferred from experiment : MTHFD1 ( Homo sapiens )
10-formyltetrahydrofolate synthetase Inferred from experiment : SFS1 ( Spinacia oleracea )
10-formyltetrahydrofolate synthetase Inferred by computational analysis Inferred from experiment : THFS ( Arabidopsis thaliana col )
formate-tetrahydrofolate ligase Inferred from experiment : ftfL ( Methylobacterium extorquens AM1 )
formyltetrahydrofolate synthetase Inferred from experiment : ftfL ( Moorella thermoacetica )

In Pathway: reductive acetyl coenzyme A pathway , formate reduction to 5,10-methylenetetrahydrofolate , folate transformations II , folate transformations I , folate polyglutamylation

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: formate—tetrahydrofolate ligase

Enzyme Commission Synonyms: formyltetrahydrofolate synθse, 10-formyltetrahydrofolate synθse, tetrahydrofolic formylase, tetrahydrofolate formylase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -25.441711 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This reaction is involved in 1-carbon metabolism.

Citations: [WHITELEY59, RABINOWITZ62, JAENICKE61]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R00943 , Rhea:20221

Relationship Links: BRENDA:EC:6.3.4.3 , ENZYME:EC:6.3.4.3 , IUBMB-ExplorEnz:EC:6.3.4.3 , UniProt:RELATED-TO:P07245 , UniProt:RELATED-TO:P09440 , UniProt:RELATED-TO:P11586 , UniProt:RELATED-TO:P13419 , UniProt:RELATED-TO:P21164 , UniProt:RELATED-TO:P28723 , UniProt:RELATED-TO:Q9CH07 , UniProt:RELATED-TO:Q9JVY8 , UniProt:RELATED-TO:Q07064 , UniProt:RELATED-TO:Q27772


References

JAENICKE61: JAENICKE L, BRODE E (1961). "[Research on monocarbon compounds. I. The tetrahydrofolate formylase from pigeon liver. Purification and mechanism]." Biochem Z 334;108-32. PMID: 13789141

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

RABINOWITZ62: RABINOWITZ JC, PRICER WE (1962). "Formyltetrahydrofolate synthetase. I. Isolation and crystallization of the enzyme." J Biol Chem 237;2898-902. PMID: 14489619

WHITELEY59: WHITELEY HR, OSBORN MJ, HUENNEKENS FM (1959). "Purification and properties of the formate-activating enzyme from Micrococcus aerogenes." J Biol Chem 234(6);1538-43. PMID: 13654413


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sun Nov 23, 2014, biocyc14.