MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:

Arabidopsis thaliana col : 10-formyltetrahydrofolate synthetase Inferred by computational analysis Inferred from experiment : THFS
Clostridium cylindrosporum : formate--tetrahydrofolate ligase Inferred from experiment : fhs
Homo sapiens : formyltetrahydrofolate synthetase Inferred from experiment : MTHFD1
Methylobacterium extorquens AM1 : formate-tetrahydrofolate ligase Inferred from experiment : ftfL
Moorella thermoacetica : formyltetrahydrofolate synthetase Inferred from experiment : ftfL
Spinacia oleracea : 10-formyltetrahydrofolate synthetase Inferred from experiment : SFS1

In Pathway: reductive acetyl coenzyme A pathway , formate reduction to 5,10-methylenetetrahydrofolate , folate transformations II , folate transformations I , folate polyglutamylation

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Enzyme Commission Primary Name: formate—tetrahydrofolate ligase

Enzyme Commission Synonyms: formyltetrahydrofolate synθse, 10-formyltetrahydrofolate synθse, tetrahydrofolic formylase, tetrahydrofolate formylase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -25.441711 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This reaction is involved in 1-carbon metabolism.


Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: KEGG:R00943 , Rhea:20221

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC: , UniProt:RELATED-TO:P07245 , UniProt:RELATED-TO:P09440 , UniProt:RELATED-TO:P11586 , UniProt:RELATED-TO:P13419 , UniProt:RELATED-TO:P21164 , UniProt:RELATED-TO:P28723 , UniProt:RELATED-TO:Q9CH07 , UniProt:RELATED-TO:Q9JVY8 , UniProt:RELATED-TO:Q07064 , UniProt:RELATED-TO:Q27772


JAENICKE61: JAENICKE L, BRODE E (1961). "[Research on monocarbon compounds. I. The tetrahydrofolate formylase from pigeon liver. Purification and mechanism]." Biochem Z 334;108-32. PMID: 13789141

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

RABINOWITZ62: RABINOWITZ JC, PRICER WE (1962). "Formyltetrahydrofolate synthetase. I. Isolation and crystallization of the enzyme." J Biol Chem 237;2898-902. PMID: 14489619

WHITELEY59: WHITELEY HR, OSBORN MJ, HUENNEKENS FM (1959). "Purification and properties of the formate-activating enzyme from Micrococcus aerogenes." J Biol Chem 234(6);1538-43. PMID: 13654413

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Sat Oct 10, 2015, BIOCYC14A.