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MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Arabidopsis thaliana col: 10-formyltetrahydrofolate synthetaseInferred by computational analysisInferred from experiment: THFS
Clostridium cylindrosporum: formate--tetrahydrofolate ligaseInferred from experiment: fhs
Homo sapiens: C1-THF synthaseInferred from experiment: MTHFD1
Methylobacterium extorquens AM1: formate-tetrahydrofolate ligaseInferred from experiment: ftfL
Moorella thermoacetica: formyltetrahydrofolate synthetaseInferred from experiment: ftfL
Spinacia oleracea: 10-formyltetrahydrofolate synthetaseInferred from experiment: SFS1

In Pathway: reductive acetyl coenzyme A pathway, folate transformations II, folate transformations I, folate polyglutamylation, formate assimilation into 5,10-methylenetetrahydrofolate

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Enzyme Commission Primary Name: formate—tetrahydrofolate ligase

Enzyme Commission Synonyms: formyltetrahydrofolate synthetase, 10-formyltetrahydrofolate synthetase, tetrahydrofolic formylase, tetrahydrofolate formylase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -25.441711Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This reaction is involved in 1-carbon metabolism.


Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R00943, Rhea:20221

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, UniProt:RELATED-TO:P07245, UniProt:RELATED-TO:P09440, UniProt:RELATED-TO:P11586, UniProt:RELATED-TO:P13419, UniProt:RELATED-TO:P21164, UniProt:RELATED-TO:P28723, UniProt:RELATED-TO:Q9CH07, UniProt:RELATED-TO:Q9JVY8, UniProt:RELATED-TO:Q07064, UniProt:RELATED-TO:Q27772


JAENICKE61: JAENICKE L, BRODE E (1961). "[Research on monocarbon compounds. I. The tetrahydrofolate formylase from pigeon liver. Purification and mechanism]." Biochem Z 334;108-32. PMID: 13789141

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

RABINOWITZ62: RABINOWITZ JC, PRICER WE (1962). "Formyltetrahydrofolate synthetase. I. Isolation and crystallization of the enzyme." J Biol Chem 237;2898-902. PMID: 14489619

WHITELEY59: WHITELEY HR, OSBORN MJ, HUENNEKENS FM (1959). "Purification and properties of the formate-activating enzyme from Micrococcus aerogenes." J Biol Chem 234(6);1538-43. PMID: 13654413

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Sat Apr 30, 2016, biocyc14.