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MetaCyc Reaction: 4.1.2.17

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 4.1.2.17

Enzymes and Genes:

Escherichia coli K-12 substr. MG1655: L-fuculose-phosphate aldolaseInferred from experiment: fucA
Methanocaldococcus jannaschii: fuculose-1-phosphate aldolaseInferred from experiment: MJ1418

In Pathway: lactate biosynthesis (archaea), fucose degradation

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: L-fuculose-phosphate aldolase

Enzyme Commission Synonyms: L-fuculose 1-phosphate aldolase, fuculose aldolase, L-fuculose-1-phosphate lactaldehyde-lyase

Standard Gibbs Free Energy (ΔrG): 5.630005 kcal/molInferred by computational analysis [Latendresse13]

Citations: [Dreyer96, Dreyer93, Ghalambor66 ]

Gene-Reaction Schematic

Expand/Contract the Schematic connections:

Gene-Reaction Schematic

Unification Links: KEGG:R02262, Rhea:12933

Relationship Links: BRENDA:EC:4.1.2.17, ENZYME:EC:4.1.2.17, IUBMB-ExplorEnz:EC:4.1.2.17, UniProt:RELATED-TO:O29770, UniProt:RELATED-TO:O57930, UniProt:RELATED-TO:P0AB87, UniProt:RELATED-TO:P44777, UniProt:RELATED-TO:P95075, UniProt:RELATED-TO:Q9V2A0, UniProt:RELATED-TO:Q46890, UniProt:RELATED-TO:Q57199


References

Dreyer93: Dreyer MK, Schulz GE (1993). "The spatial structure of the class II L-fuculose-1-phosphate aldolase from Escherichia coli." J Mol Biol 231(3);549-53. PMID: 8515438

Dreyer96: Dreyer MK, Schulz GE (1996). "Catalytic mechanism of the metal-dependent fuculose aldolase from Escherichia coli as derived from the structure." J Mol Biol 259(3);458-66. PMID: 8676381

Ghalambor66: Ghalambor MA, Heath EC (1966). "The biosynthesis of cell wall lipopolysaccharide in Escherichia coli. IV. Purification and properties of cytidine monophosphate 3-deoxy-d-manno-octulosonate synthetase." J Biol Chem 1966;241(13);3216-21. PMID: 5330266

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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