Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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MetaCyc Reaction: 2.7.1.6

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.7.1.6

Enzymes and Genes:
galactokinase Inferred from experiment : galK ( Escherichia coli K-12 substr. MG1655 )
galactokinase Inferred from experiment : GALK ( Cucumis melo )
galactokinase Inferred from experiment : AGK1 ( Arabidopsis thaliana col )
galactokinase Inferred from experiment ( Vicia faba )
galactokinase Inferred from experiment : galK ( Thermotoga maritima )

In Pathway: stachyose degradation , galactose degradation III , galactose degradation I (Leloir pathway) , D-galactose degradation V (Leloir pathway)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: galactokinase

Enzyme Commission Synonyms: galactokinase (phosphorylating), ATP:D-galactose-1-phosphotransferase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -14.815918 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This reaction is different from the one specified by the EC, by having α-D-galactose as a substrate (the official reaction specifies D-galactose). It has been modified since the original literature suggests that the former is the actual substrate for the enzyme .

Citations: [CARDINI53, Neufeld60, Wilkinson49]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R01092 , Rhea:13553

Relationship Links: BRENDA:EC:2.7.1.6 , ENZYME:EC:2.7.1.6 , IUBMB-ExplorEnz:EC:2.7.1.6 , UniProt:RELATED-TO:P04385 , UniProt:RELATED-TO:P09608 , UniProt:RELATED-TO:P0A6T3 , UniProt:RELATED-TO:P13045 , UniProt:RELATED-TO:P13227 , UniProt:RELATED-TO:P22713 , UniProt:RELATED-TO:P31767 , UniProt:RELATED-TO:P39574 , UniProt:RELATED-TO:P96993 , UniProt:RELATED-TO:Q8X7P4 , UniProt:RELATED-TO:Q9R7D7 , UniProt:RELATED-TO:Q9SEE5 , UniProt:RELATED-TO:Q01415


References

CARDINI53: CARDINI CE, LELOIR LF (1953). "Enzymic phosphorylation of galactosamine and galactose." Arch Biochem Biophys 45(1);55-64. PMID: 13058412

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Neufeld60: Neufeld E.F., Feingold D.S., Hassid W.Z. (1960). "Phosphorylation of D-galactose and L-arabinose by extracts from Phaseolus aureus seedlings." J Biol Chem 235;906-9. PMID: 14426659

Wilkinson49: Wilkinson JF (1949). "The pathway of the adaptive fermentation of galactose by yeast." Biochem J 44(4);460-7. PMID: 16748546


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Mon Dec 22, 2014, BIOCYC14B.