Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 2.7.1.6

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.7.1.6

Enzymes and Genes:
galactokinase Inferred from experiment : galK ( Escherichia coli K-12 substr. MG1655 )
galactokinase Inferred from experiment : GALK ( Cucumis melo )
galactokinase Inferred from experiment : AGK1 ( Arabidopsis thaliana col )
galactokinase Inferred from experiment ( Vicia faba )
galactokinase Inferred from experiment : galK ( Thermotoga maritima )

In Pathway: stachyose degradation , galactose degradation III , galactose degradation I (Leloir pathway) , D-galactose degradation V (Leloir pathway)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: galactokinase

Enzyme Commission Synonyms: galactokinase (phosphorylating), ATP:D-galactose-1-phosphotransferase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -14.815918 Inferred by computational analysis [Latendresse, 2013]

Enzyme Commission Summary:
This reaction is different from the one specified by the EC, by having α-D-galactose as a substrate (the official reaction specifies D-galactose). It has been modified since the original literature suggests that the former is the actual substrate for the enzyme .

Citations: [CARDINI53, Neufeld60, Wilkinson49]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R01092 , Rhea:13553

Relationship Links: BRENDA:EC:2.7.1.6 , ENZYME:EC:2.7.1.6 , IUBMB-ExplorEnz:EC:2.7.1.6 , UniProt:RELATED-TO:P04385 , UniProt:RELATED-TO:P09608 , UniProt:RELATED-TO:P0A6T3 , UniProt:RELATED-TO:P13045 , UniProt:RELATED-TO:P13227 , UniProt:RELATED-TO:P22713 , UniProt:RELATED-TO:P31767 , UniProt:RELATED-TO:P39574 , UniProt:RELATED-TO:P96993 , UniProt:RELATED-TO:Q8X7P4 , UniProt:RELATED-TO:Q9R7D7 , UniProt:RELATED-TO:Q9SEE5 , UniProt:RELATED-TO:Q01415


References

CARDINI53: CARDINI CE, LELOIR LF (1953). "Enzymic phosphorylation of galactosamine and galactose." Arch Biochem Biophys 45(1);55-64. PMID: 13058412

Latendresse, 2013: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Neufeld60: Neufeld E.F., Feingold D.S., Hassid W.Z. (1960). "Phosphorylation of D-galactose and L-arabinose by extracts from Phaseolus aureus seedlings." J Biol Chem 235;906-9. PMID: 14426659

Wilkinson49: Wilkinson JF (1949). "The pathway of the adaptive fermentation of galactose by yeast." Biochem J 44(4);460-7. PMID: 16748546


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sat Nov 22, 2014, biocyc13.