|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions → Protein-Modification Reactions|
|Reactions Classified By Substrate → Macromolecule Reactions → Protein-Reactions → Protein-Modification Reactions|
EC Number: 220.127.116.11
Enzymes and Genes:
glycine decarboxylase : gcvP ( Escherichia coli K-12 substr. MG1655 )
glycine decarboxylase : GLDC ( Homo sapiens )
glycine decarboxylase : GLDC ( Gallus gallus )
glycine decarboxylase : AT2G35370 ( Arabidopsis thaliana col )
glycine decarboxylase : AT2G35120 ( Arabidopsis thaliana col )
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: glycine dehydrogenase (aminomethyl-transferring)
Enzyme Commission Synonyms: P-protein, glycine decarboxylase, glycine-cleavage complex, glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating), protein P1, glycine dehydrogenase (decarboxylating), glycine cleavage system P-protein, glycine-cleavage complex P-protein
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -56.676727 [Latendresse13]
Enzyme Commission Summary:
A pyridoxal-phosphate protein. A component of the glycine cleavage system, which is composed of four components that only loosely associate: the P protein (EC 18.104.22.168), the T protein (EC 22.214.171.124), the L protein (EC 126.96.36.199) and the lipoyl-bearing H protein [Nesbitt05]. Previously known as glycine synthase.
Relationship Links: BRENDA:EC:188.8.131.52 , ENZYME:EC:184.108.40.206 , IUBMB-ExplorEnz:EC:220.127.116.11 , UniProt:RELATED-TO:O22575 , UniProt:RELATED-TO:O32915 , UniProt:RELATED-TO:O80988 , UniProt:RELATED-TO:P23378 , UniProt:RELATED-TO:P26969 , UniProt:RELATED-TO:P33195 , UniProt:RELATED-TO:Q94B78 , UniProt:RELATED-TO:Q9JT86 , UniProt:RELATED-TO:Q9UXT0 , UniProt:RELATED-TO:Q9UXT1
Hiraga80: Hiraga K, Kikuchi G (1980). "The mitochondrial glycine cleavage system. Functional association of glycine decarboxylase and aminomethyl carrier protein." J Biol Chem 255(24);11671-6. PMID: 7440563
Nesbitt05: Nesbitt NM, Baleanu-Gogonea C, Cicchillo RM, Goodson K, Iwig DF, Broadwater JA, Haas JA, Fox BG, Booker SJ (2005). "Expression, purification, and physical characterization of Escherichia coli lipoyl(octanoyl)transferase." Protein Expr Purif 39(2);269-82. PMID: 15642479
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