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MetaCyc Reaction: 1.4.4.2

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Protein-Modification Reactions
Reactions Classified By Substrate Macromolecule Reactions Protein-Reactions Protein-Modification Reactions

EC Number: 1.4.4.2

Enzymes and Genes:

Arabidopsis thaliana col : glycine decarboxylase : AT2G35120
glycine decarboxylase : AT2G35370
Escherichia coli K-12 substr. MG1655 : glycine decarboxylase Inferred from experiment : gcvP
Gallus gallus : glycine decarboxylase Inferred from experiment : GLDC
Homo sapiens : glycine decarboxylase Inferred from experiment : GLDC

Sub-reaction of:
glycine + a tetrahydrofolate + NAD+ ↔ a 5,10-methylene-tetrahydrofolate + ammonium + CO2 + NADH

In Pathway: glycine cleavage , glycine biosynthesis II

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: glycine dehydrogenase (aminomethyl-transferring)

Enzyme Commission Synonyms: P-protein, glycine decarboxylase, glycine-cleavage complex, glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating), protein P1, glycine dehydrogenase (decarboxylating), glycine cleavage system P-protein, glycine-cleavage complex P-protein

Standard Gibbs Free Energy (ΔrG in kcal/mol): -56.676727 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A pyridoxal-phosphate protein. A component of the glycine cleavage system, which is composed of four components that only loosely associate: the P protein (EC 1.4.4.2), the T protein (EC 2.1.2.10), the L protein (EC 1.8.1.4) and the lipoyl-bearing H protein [Nesbitt05]. Previously known as glycine synthase.

Citations: [Hiraga80, Perham00]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Instance reactions of [a [lipoyl-carrier protein] N6-dihydrolipoyl-L-lysine + NAD+ → a [lipoyl-carrier protein] N6-lipoyl-L-lysine + NADH + H+] (1.8.1.4):
i1: a [pyruvate dehydrogenase E2 protein] N6-dihydrolipoyl-L-lysine + NAD+ ↔ a [pyruvate dehydrogenase E2 protein] N6-lipoyl-L-lysine + NADH + H+ (1.8.1.4)

i2: a [2-oxoglutarate dehydrogenase E2 protein] N6-dihydrolipoyl-L-lysine + NAD+ ↔ a [2-oxoglutarate dehydrogenase E2 protein] N6-lipoyl-L-lysine + NADH + H+ (1.8.1.4)

i3: a [glycine-cleavage complex H protein] N6-dihydrolipoyl-L-lysine + NAD+ ↔ a [glycine-cleavage complex H protein] N6-lipoyl-L-lysine + NADH + H+ (1.8.1.4)

i4: an [apo BCAA dehydrogenase E2 protein] N6-dihydrolipoyl-L-lysine + NAD+ ↔ an [apo BCAA dehydrogenase E2 protein] N6-lipoyl-L-lysine + NADH + H+ (1.8.1.4)

Relationship Links: BRENDA:EC:1.4.4.2 , ENZYME:EC:1.4.4.2 , IUBMB-ExplorEnz:EC:1.4.4.2 , UniProt:RELATED-TO:O22575 , UniProt:RELATED-TO:O32915 , UniProt:RELATED-TO:O80988 , UniProt:RELATED-TO:P23378 , UniProt:RELATED-TO:P26969 , UniProt:RELATED-TO:P33195 , UniProt:RELATED-TO:Q94B78 , UniProt:RELATED-TO:Q9JT86 , UniProt:RELATED-TO:Q9UXT0 , UniProt:RELATED-TO:Q9UXT1

Credits:
Revised 18-Sep-2012 by Caspi R , SRI International


References

Hiraga80: Hiraga K, Kikuchi G (1980). "The mitochondrial glycine cleavage system. Functional association of glycine decarboxylase and aminomethyl carrier protein." J Biol Chem 255(24);11671-6. PMID: 7440563

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Nesbitt05: Nesbitt NM, Baleanu-Gogonea C, Cicchillo RM, Goodson K, Iwig DF, Broadwater JA, Haas JA, Fox BG, Booker SJ (2005). "Expression, purification, and physical characterization of Escherichia coli lipoyl(octanoyl)transferase." Protein Expr Purif 39(2);269-82. PMID: 15642479

Perham00: Perham RN (2000). "Swinging arms and swinging domains in multifunctional enzymes: catalytic machines for multistep reactions." Annu Rev Biochem 69;961-1004. PMID: 10966480


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Sat Aug 29, 2015, biocyc12.