|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions → Protein-Modification Reactions|
|Reactions Classified By Substrate → Macromolecule Reactions → Protein-Reactions → Protein-Modification Reactions|
EC Number: 220.127.116.11
Enzymes and Genes:
|Arabidopsis thaliana col:||glycine decarboxylase: AT2G35120|
glycine decarboxylase: AT2G35370
|Escherichia coli K-12 substr. MG1655:||glycine decarboxylase: gcvP|
|Gallus gallus:||glycine decarboxylase: GLDC|
|Homo sapiens:||glycine decarboxylase: GLDC|
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.
Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: glycine dehydrogenase (aminomethyl-transferring)
Enzyme Commission Synonyms: P-protein, glycine decarboxylase, glycine-cleavage complex, glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating), protein P1, glycine dehydrogenase (decarboxylating), glycine cleavage system P-protein, glycine-cleavage complex P-protein
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -56.676727 [Latendresse13]
Enzyme Commission Summary:
A pyridoxal-phosphate protein. A component of the glycine cleavage system, which is composed of four components that only loosely associate: the P protein ( EC 18.104.22.168), the T protein ( EC 22.214.171.124), the L protein ( EC 126.96.36.199) and the lipoyl-bearing H protein [Nesbitt05]. Previously known as glycine synthase.
Unification Links: KEGG:R03425
Relationship Links: BRENDA:EC:188.8.131.52, ENZYME:EC:184.108.40.206, IUBMB-ExplorEnz:EC:220.127.116.11, UniProt:RELATED-TO:O22575, UniProt:RELATED-TO:O32915, UniProt:RELATED-TO:O80988, UniProt:RELATED-TO:P23378, UniProt:RELATED-TO:P26969, UniProt:RELATED-TO:P33195, UniProt:RELATED-TO:Q94B78, UniProt:RELATED-TO:Q9JT86, UniProt:RELATED-TO:Q9UXT0, UniProt:RELATED-TO:Q9UXT1
Hiraga80a: Hiraga K, Kikuchi G (1980). "The mitochondrial glycine cleavage system. Functional association of glycine decarboxylase and aminomethyl carrier protein." J Biol Chem 255(24);11671-6. PMID: 7440563
Nesbitt05: Nesbitt NM, Baleanu-Gogonea C, Cicchillo RM, Goodson K, Iwig DF, Broadwater JA, Haas JA, Fox BG, Booker SJ (2005). "Expression, purification, and physical characterization of Escherichia coli lipoyl(octanoyl)transferase." Protein Expr Purif 39(2);269-82. PMID: 15642479
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