Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 1.4.4.2

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Protein-Modification Reactions
Reactions Classified By Substrate Macromolecule Reactions Protein-Reactions Protein-Modification Reactions

EC Number: 1.4.4.2

Enzymes and Genes:
glycine decarboxylase Inferred from experiment : gcvP ( Escherichia coli K-12 substr. MG1655 )
glycine decarboxylase Inferred from experiment : GLDC ( Homo sapiens )
glycine decarboxylase Inferred from experiment : GLDC ( Gallus gallus )
glycine decarboxylase : AT2G35370 ( Arabidopsis thaliana col )
glycine decarboxylase : AT2G35120 ( Arabidopsis thaliana col )

Sub-reaction of:
glycine + a tetrahydrofolate + NAD+ ↔ a 5,10-methylene-tetrahydrofolate + ammonium + CO2 + NADH

In Pathway: glycine cleavage , glycine biosynthesis II

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: glycine dehydrogenase (aminomethyl-transferring)

Enzyme Commission Synonyms: P-protein, glycine decarboxylase, glycine-cleavage complex, glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating), protein P1, glycine dehydrogenase (decarboxylating), glycine cleavage system P-protein, glycine-cleavage complex P-protein

Standard Gibbs Free Energy (ΔrG in kcal/mol): -56.676727 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A pyridoxal-phosphate protein. A component of the glycine cleavage system, which is composed of four components that only loosely associate: the P protein (EC 1.4.4.2), the T protein (EC 2.1.2.10), the L protein (EC 1.8.1.4) and the lipoyl-bearing H protein [Nesbitt05]. Previously known as glycine synthase.

Citations: [Hiraga80, Perham00]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:1.4.4.2 , ENZYME:EC:1.4.4.2 , IUBMB-ExplorEnz:EC:1.4.4.2 , UniProt:RELATED-TO:O22575 , UniProt:RELATED-TO:O32915 , UniProt:RELATED-TO:O80988 , UniProt:RELATED-TO:P23378 , UniProt:RELATED-TO:P26969 , UniProt:RELATED-TO:P33195 , UniProt:RELATED-TO:Q94B78 , UniProt:RELATED-TO:Q9JT86 , UniProt:RELATED-TO:Q9UXT0 , UniProt:RELATED-TO:Q9UXT1

Credits:
Revised 18-Sep-2012 by Caspi R , SRI International


References

Hiraga80: Hiraga K, Kikuchi G (1980). "The mitochondrial glycine cleavage system. Functional association of glycine decarboxylase and aminomethyl carrier protein." J Biol Chem 255(24);11671-6. PMID: 7440563

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Nesbitt05: Nesbitt NM, Baleanu-Gogonea C, Cicchillo RM, Goodson K, Iwig DF, Broadwater JA, Haas JA, Fox BG, Booker SJ (2005). "Expression, purification, and physical characterization of Escherichia coli lipoyl(octanoyl)transferase." Protein Expr Purif 39(2);269-82. PMID: 15642479

Perham00: Perham RN (2000). "Swinging arms and swinging domains in multifunctional enzymes: catalytic machines for multistep reactions." Annu Rev Biochem 69;961-1004. PMID: 10966480


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sun Nov 23, 2014, BIOCYC14B.