MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Escherichia coli K-12 substr. MG1655: aldehyde reductase, NADPH-dependent: yahK
aldehyde reductase, NADPH-dependent: ahr
NADP+-dependent aldehyde reductase: ybbO
NADPH-dependent aldehyde reductase: yqhD
Ocimum basilicum: geraniol dehydrogenaseInferred from experiment: GEDH1
geraniol dehydrogenaseInferred from experiment: CAD1

In Pathway: geraniol and geranial biosynthesis

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: geraniol dehydrogenase (NADP+)

Standard Gibbs Free Energy (ΔrG in kcal/mol): -0.25653076Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The enzyme also acts (more slowly) on farnesol, but not on nerol. The enzyme produces a mixture known as citral, which includes geranial and neral. It is still not known whether neral is produced directly by the enzyme, or by isomerization of geranial.

Citations: [SekiwaIijima01, Noge08, Saito11a ]

Gene-Reaction Schematic

Gene-Reaction Schematic

Instance reaction of [an alcohol + NADP+ = an aldehyde + NADPH + H+] (
i1: geraniol + NADP+ → geranial + NADPH + H+ (

Unification Links: KEGG:R03581, Rhea:14521

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:

Revised 07-Nov-2011 by Caspi R, SRI International


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Noge08: Noge K, Kato M, Mori N, Kataoka M, Tanaka C, Yamasue Y, Nishida R, Kuwahara Y (2008). "Geraniol dehydrogenase, the key enzyme in biosynthesis of the alarm pheromone, from the astigmatid mite Carpoglyphus lactis (Acari: Carpoglyphidae)." FEBS J 275(11);2807-17. PMID: 18422649

Saito11a: Saito Y, Ito S, Koltunow AM, Sakai H (2011). "Crystallization and preliminary X-ray analysis of geraniol dehydrogenase from Backhousia citriodora (lemon myrtle)." Acta Crystallogr Sect F Struct Biol Cryst Commun 67(Pt 6);665-7. PMID: 21636906

SekiwaIijima01: Sekiwa-Iijima Y, Aizawa Y, Kubota K (2001). "Geraniol dehydrogenase activity related to aroma formation in ginger (Zingiber officinale Roscoe)." J Agric Food Chem 49(12);5902-6. PMID: 11743782

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.5 on Mon Nov 30, 2015, BIOCYC13A.