Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 1.1.1.183

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.1.1.183

Enzymes and Genes:
geraniol dehydrogenase Inferred from experiment : CAD1 ( Ocimum basilicum )
geraniol dehydrogenase Inferred from experiment : GEDH1 ( Ocimum basilicum )
aldehyde reductase, NADPH-dependent : yahK ( Escherichia coli K-12 substr. MG1655 )
NADP+-dependent aldehyde reductase : ybbO ( Escherichia coli K-12 substr. MG1655 )
aldehyde reductase, NADPH-dependent : ahr ( Escherichia coli K-12 substr. MG1655 )
NADPH-dependent aldehyde reductase : yqhD ( Escherichia coli K-12 substr. MG1655 )

In Pathway: geraniol and geranial biosynthesis

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: geraniol dehydrogenase (NADP+)

Standard Gibbs Free Energy (ΔrG in kcal/mol): -0.25653076 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The enzyme also acts (more slowly) on farnesol, but not on nerol. The enzyme produces a mixture known as citral, which includes geranial and neral. It is still not known whether neral is produced directly by the enzyme, or by isomerization of geranial.

Citations: [SekiwaIijima01, Noge08, Saito11a]

Gene-Reaction Schematic: ?

Instance reaction of [an alcohol + NADP+ = an aldehyde + NADPH + H+] (1.1.1.2):
i1: geraniol + NADP+ → geranial + NADPH + H+ (1.1.1.183)

Unification Links: KEGG:R03581 , Rhea:14521

Relationship Links: BRENDA:EC:1.1.1.183 , ENZYME:EC:1.1.1.183 , IUBMB-ExplorEnz:EC:1.1.1.183

Credits:
Revised 07-Nov-2011 by Caspi R , SRI International


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Noge08: Noge K, Kato M, Mori N, Kataoka M, Tanaka C, Yamasue Y, Nishida R, Kuwahara Y (2008). "Geraniol dehydrogenase, the key enzyme in biosynthesis of the alarm pheromone, from the astigmatid mite Carpoglyphus lactis (Acari: Carpoglyphidae)." FEBS J 275(11);2807-17. PMID: 18422649

Saito11a: Saito Y, Ito S, Koltunow AM, Sakai H (2011). "Crystallization and preliminary X-ray analysis of geraniol dehydrogenase from Backhousia citriodora (lemon myrtle)." Acta Crystallogr Sect F Struct Biol Cryst Commun 67(Pt 6);665-7. PMID: 21636906

SekiwaIijima01: Sekiwa-Iijima Y, Aizawa Y, Kubota K (2001). "Geraniol dehydrogenase activity related to aroma formation in ginger (Zingiber officinale Roscoe)." J Agric Food Chem 49(12);5902-6. PMID: 11743782


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sun Nov 23, 2014, biocyc14.