|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.168
Enzymes and Genes:
|Escherichia coli K-12 substr. MG1655:||aldehyde reductase, NADPH-dependent: yahK|
aldehyde reductase, NADPH-dependent: ahr
NADP+-dependent aldehyde reductase: ybbO
NADPH-dependent aldehyde reductase: yqhD
|Ocimum basilicum:||geraniol dehydrogenase: GEDH1|
geraniol dehydrogenase: CAD1
In Pathway: geraniol and geranial biosynthesis
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: geraniol dehydrogenase (NADP+)
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -0.25653076 [Latendresse13]
Enzyme Commission Summary:
The enzyme also acts (more slowly) on farnesol, but not on nerol. The enzyme produces a mixture known as citral, which includes geranial and neral. It is still not known whether neral is produced directly by the enzyme, or by isomerization of geranial.
Noge08: Noge K, Kato M, Mori N, Kataoka M, Tanaka C, Yamasue Y, Nishida R, Kuwahara Y (2008). "Geraniol dehydrogenase, the key enzyme in biosynthesis of the alarm pheromone, from the astigmatid mite Carpoglyphus lactis (Acari: Carpoglyphidae)." FEBS J 275(11);2807-17. PMID: 18422649
Saito11a: Saito Y, Ito S, Koltunow AM, Sakai H (2011). "Crystallization and preliminary X-ray analysis of geraniol dehydrogenase from Backhousia citriodora (lemon myrtle)." Acta Crystallogr Sect F Struct Biol Cryst Commun 67(Pt 6);665-7. PMID: 21636906
SekiwaIijima01: Sekiwa-Iijima Y, Aizawa Y, Kubota K (2001). "Geraniol dehydrogenase activity related to aroma formation in ginger (Zingiber officinale Roscoe)." J Agric Food Chem 49(12);5902-6. PMID: 11743782
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