|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.168
Enzymes and Genes:
geraniol dehydrogenase : CAD1 ( Ocimum basilicum )
geraniol dehydrogenase : GEDH1 ( Ocimum basilicum )
aldehyde reductase, NADPH-dependent : yahK ( Escherichia coli K-12 substr. MG1655 )
NADP+-dependent aldehyde reductase : ybbO ( Escherichia coli K-12 substr. MG1655 )
aldehyde reductase, NADPH-dependent : ahr ( Escherichia coli K-12 substr. MG1655 )
NADPH-dependent aldehyde reductase : yqhD ( Escherichia coli K-12 substr. MG1655 )
In Pathway: geraniol and geranial biosynthesis
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: geraniol dehydrogenase (NADP+)
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -0.25653076 [Latendresse13]
Enzyme Commission Summary:
The enzyme also acts (more slowly) on farnesol, but not on nerol. The enzyme produces a mixture known as citral, which includes geranial and neral. It is still not known whether neral is produced directly by the enzyme, or by isomerization of geranial.
Instance reaction of [an alcohol + NADP+ = an aldehyde + NADPH + H+] (22.214.171.124):
i1: geraniol + NADP+ → geranial + NADPH + H+ (126.96.36.199)
Noge08: Noge K, Kato M, Mori N, Kataoka M, Tanaka C, Yamasue Y, Nishida R, Kuwahara Y (2008). "Geraniol dehydrogenase, the key enzyme in biosynthesis of the alarm pheromone, from the astigmatid mite Carpoglyphus lactis (Acari: Carpoglyphidae)." FEBS J 275(11);2807-17. PMID: 18422649
Saito11: Saito Y, Ito S, Koltunow AM, Sakai H (2011). "Crystallization and preliminary X-ray analysis of geraniol dehydrogenase from Backhousia citriodora (lemon myrtle)." Acta Crystallogr Sect F Struct Biol Cryst Commun 67(Pt 6);665-7. PMID: 21636906
SekiwaIijima01: Sekiwa-Iijima Y, Aizawa Y, Kubota K (2001). "Geraniol dehydrogenase activity related to aroma formation in ginger (Zingiber officinale Roscoe)." J Agric Food Chem 49(12);5902-6. PMID: 11743782
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