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MetaCyc Reaction: 2.3.1.4

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.3.1.4

Enzymes and Genes:
glucosamine-6-phosphate acetyltransferase Inferred from experiment Inferred by computational analysis : GNA1 ( Arabidopsis thaliana col )
glucosamine-6-phosphate N-acetyltransferase Inferred from experiment : Gna ( Aedes aegypti )
glucosamine 6-phosphate N-acetylase Inferred from experiment : GNA ( Giardia intestinalis )
glucosamine-6-phosphate N-acetyltransferase 1 Inferred from experiment : Gnpnat1 ( Mus musculus )
glucosamine-6-phosphate N-acetyltransferase 1 Inferred from experiment : GNA1 ( Saccharomyces cerevisiae )

In Pathway: UDP-N-acetyl-D-glucosamine biosynthesis II , UDP-N-acetyl-D-galactosamine biosynthesis II

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: glucosamine-phosphate N-acetyltransferase

Enzyme Commission Synonyms: phosphoglucosamine transacetylase, phosphoglucosamine acetylase, glucosamine-6-phosphate acetylase, D-glucosamine-6-P N-acetyltransferase, aminodeoxyglucosephosphate acetyltransferase, glucosamine 6-phosphate acetylase, glucosamine 6-phosphate N-acetyltransferase, N-acetylglucosamine-6-phosphate synthase, phosphoglucosamine N-acetylase, glucosamine-6-phosphate N-acetyltransferase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -6.538269 Inferred by computational analysis [Latendresse13]

Citations: [Boehmelt00, PATTABIRAMAN62, DAVIDSON57]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: KEGG:R02058 , Rhea:10292

Relationship Links: BRENDA:EC:2.3.1.4 , ENZYME:EC:2.3.1.4 , IUBMB-ExplorEnz:EC:2.3.1.4 , UniProt:RELATED-TO:O13738 , UniProt:RELATED-TO:P43577


References

Boehmelt00: Boehmelt G, Fialka I, Brothers G, McGinley MD, Patterson SD, Mo R, Hui CC, Chung S, Huber LA, Mak TW, Iscove NN (2000). "Cloning and characterization of the murine glucosamine-6-phosphate acetyltransferase EMeg32. Differential expression and intracellular membrane association." J Biol Chem 275(17);12821-32. PMID: 10777580

DAVIDSON57: DAVIDSON EA, BLUMENTHAL HJ, ROSEMAN S (1957). "Glucosamine metabolism. II. Studies on glucosamine 6-phosphate N-acetylase." J Biol Chem 226(1);125-33. PMID: 13428743

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

PATTABIRAMAN62: PATTABIRAMAN TN, BACHHAWAT BK (1962). "Purification of glucosamine-6-phosphate N-acetylase from sheep brain." Biochim Biophys Acta 59;681-9. PMID: 14484387


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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