|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
Enzymes and Genes:
|Arabidopsis thaliana col :||purple acid phosphatase [multifunctional]
|Escherichia coli K-12 substr. MG1655 :||alkaline phosphatase
sugar phosphatase : ybiV
sugar phosphatase : yidA
phosphosugar phosphatase : yigL
sugar phosphatase : yfbT
|Homo sapiens :||glucose-6-phosphatase
glucose-6-phosphatase 3 : G6PC3
glucose-6-phosphatase 2 : G6PC2
Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .
Reaction Locations: cytosol, periplasmic space (sensu Gram-negative Bacteria)
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.
Mass balance status: Balanced.
Direct generic reaction:
D-glucopyranose 6-phosphate + H2O → D-glucopyranose + phosphate (18.104.22.168/22.214.171.124)
Enzyme Commission Primary Name for 126.96.36.199: glucose-6-phosphatase
Enzyme Commission Synonyms for 188.8.131.52: glucose 6-phosphate phosphatase
Enzyme Commission Primary Name for 184.108.40.206: sugar-terminal-phosphatase
Enzyme Commission Synonyms for 220.127.116.11: xylitol-5-phosphatase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): 7.2170105 [Latendresse13]
Enzyme Commission Summary for 18.104.22.168:
Wide distribution in animal tissues. Also catalyses potent transphosphorylations from carbamoyl phosphate, hexose phosphates, diphosphate, phosphoenolpyruvate and nucleoside di- and triphosphates, to D-glucose, D-mannose, 3-methyl-D-glucose or 2-deoxy-D-glucose [cf. EC 22.214.171.124 (phosphoramidate—hexose phosphotransferase}, EC 126.96.36.199 (diphosphate—glycerol phosphotransferase) and EC 188.8.131.52 (phosphoamidase)].
Enzyme Commission Summary for 184.108.40.206:
Acts on sugars and polyols phosphorylated on the terminal carbon, with a preference for sugars with a D-erythro-configuration, e.g. good substrates are glucose 6-phosphate, mannose 6-phosphate, 6-phosphogluconate, erythrose 4-phosphate and xylitol 5-phosphate.
Instance reaction of [D-glucopyranose 6-phosphate + H2O → D-glucopyranose + phosphate] (220.127.116.11/18.104.22.168):
i1: β-D-glucose 6-phosphate + H2O → β-D-glucopyranose + phosphate (22.214.171.124/126.96.36.199)
Relationship Links: BRENDA:EC:188.8.131.52 , BRENDA:EC:184.108.40.206 , ENZYME:EC:220.127.116.11 , ENZYME:EC:18.104.22.168 , IUBMB-ExplorEnz:EC:22.214.171.124 , IUBMB-ExplorEnz:EC:126.96.36.199 , UniProt:RELATED-TO:P35575 , UniProt:RELATED-TO:P35576 , UniProt:RELATED-TO:P43428
Colilla75: Colilla W, Jorgenson RA, Nordlie RC (1975). "Mammalian carbamyl phosphate : glucose phosphotransferase and glucose-6-phosphate phosphohydrolase: extended tissue distribution." Biochim Biophys Acta 377(1);117-25. PMID: 164220
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