Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015
Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015
Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015
Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015
Pathway Tools
Intro Tutorial
discounted registration ends Sept 5, 2015
twitter

MetaCyc Reaction: 3.1.3.9/3.1.3.58

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.1.3.9 , 3.1.3.58

Enzymes and Genes:

Arabidopsis thaliana col : purple acid phosphatase [multifunctional] Inferred from experiment : PAP26
Escherichia coli K-12 substr. MG1655 : alkaline phosphatase Inferred from experiment : phoA
sugar phosphatase : ybiV
sugar phosphatase : yidA
phosphosugar phosphatase : yigL
sugar phosphatase : yfbT
Homo sapiens : glucose-6-phosphatase Inferred from experiment : G6PC
glucose-6-phosphatase 3 Inferred from experiment : G6PC3
glucose-6-phosphatase 2 Inferred from experiment : G6PC2

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

Reaction Locations: cytosol, periplasmic space (sensu Gram-negative Bacteria)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Direct generic reaction:
D-glucopyranose 6-phosphate + H2O → D-glucopyranose + phosphate (3.1.3.9/3.1.3.58)

Enzyme Commission Primary Name for 3.1.3.9: glucose-6-phosphatase

Enzyme Commission Synonyms for 3.1.3.9: glucose 6-phosphate phosphatase

Enzyme Commission Primary Name for 3.1.3.58: sugar-terminal-phosphatase

Enzyme Commission Synonyms for 3.1.3.58: xylitol-5-phosphatase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 7.2170105 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary for 3.1.3.9:
Wide distribution in animal tissues. Also catalyses potent transphosphorylations from carbamoyl phosphate, hexose phosphates, diphosphate, phosphoenolpyruvate and nucleoside di- and triphosphates, to D-glucose, D-mannose, 3-methyl-D-glucose or 2-deoxy-D-glucose [cf. EC 2.7.1.62 (phosphoramidate—hexose phosphotransferase}, EC 2.7.1.79 (diphosphate—glycerol phosphotransferase) and EC 3.9.1.1 (phosphoamidase)].

Enzyme Commission Summary for 3.1.3.58:
Acts on sugars and polyols phosphorylated on the terminal carbon, with a preference for sugars with a D-erythro-configuration, e.g. good substrates are glucose 6-phosphate, mannose 6-phosphate, 6-phosphogluconate, erythrose 4-phosphate and xylitol 5-phosphate.

Citations: [Anchors75, Colilla75, Nordlie74, London85]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Instance reaction of [D-glucopyranose 6-phosphate + H2O → D-glucopyranose + phosphate] (3.1.3.9/3.1.3.58):
i1: β-D-glucose 6-phosphate + H2O → β-D-glucopyranose + phosphate (3.1.3.9/3.1.3.58)

Relationship Links: BRENDA:EC:3.1.3.9 , BRENDA:EC:3.1.3.58 , ENZYME:EC:3.1.3.9 , ENZYME:EC:3.1.3.58 , IUBMB-ExplorEnz:EC:3.1.3.9 , IUBMB-ExplorEnz:EC:3.1.3.58 , UniProt:RELATED-TO:P35575 , UniProt:RELATED-TO:P35576 , UniProt:RELATED-TO:P43428

Credits:
Revised 06-Apr-2011 by Caspi R , SRI International


References

Anchors75: Anchors JM, Karnovsky ML (1975). "Purification of cerebral glucose-6-phosphatase. An enzyme involved in sleep." J Biol Chem 250(16);6408-16. PMID: 169241

Colilla75: Colilla W, Jorgenson RA, Nordlie RC (1975). "Mammalian carbamyl phosphate : glucose phosphotransferase and glucose-6-phosphate phosphohydrolase: extended tissue distribution." Biochim Biophys Acta 377(1);117-25. PMID: 164220

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

London85: London J, Hausman SZ, Thompson J (1985). "Characterization of a membrane-regulated sugar phosphate phosphohydrolase from Lactobacillus casei." J Bacteriol 163(3);951-6. PMID: 2993253

Nordlie74: Nordlie RC (1974). "Metabolic regulation by multifunctional glucose-6-phosphatase." Curr Top Cell Regul 8(0);33-117. PMID: 4370737


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Sun Aug 30, 2015, biocyc14.