MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Arabidopsis thaliana col: δ1-pyrroline-5-carboxylate synthetaseInferred from experimentInferred by computational analysis: P5CS1
Escherichia coli K-12 substr. MG1655: γ-glutamyl kinaseInferred from experiment: proB
Homo sapiens: δ-1-pyrroline-5-carboxylate synthaseInferred from experiment: ALDH18A1
Vigna aconitifolia: glutamate 5-kinaseInferred from experiment: P5CS

In Pathway: L-ornithine biosynthesis II, L-proline biosynthesis I, L-citrulline biosynthesis, L-proline biosynthesis III, L-Nδ-acetylornithine biosynthesis

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: glutamate 5-kinase

Enzyme Commission Synonyms: ATP-L-glutamate 5-phosphotransferase, ATP:γ-L-glutamate phosphotransferase, γ-glutamate kinase, γ-glutamyl kinase, glutamate kinase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 8.53833Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This is the first step in the proline biosynthesis pathway.

The product rapidly cyclizes to 5-oxoproline and orthophosphate. [Bairoch93a]

Citations: [Baich69]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R00239, Rhea:14877

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, UniProt:RELATED-TO:O04226, UniProt:RELATED-TO:O13810, UniProt:RELATED-TO:P0A7B5, UniProt:RELATED-TO:P17856, UniProt:RELATED-TO:P32264, UniProt:RELATED-TO:P43763, UniProt:RELATED-TO:P46546, UniProt:RELATED-TO:P73071, UniProt:RELATED-TO:Q9CF72, UniProt:RELATED-TO:Q9JUK7, UniProt:RELATED-TO:Q9PJ29


Baich69: Baich A (1969). "Proline synthesis in Escherichia coli. A proline-inhibitable glutamic acid kinase." Biochim Biophys Acta 1969;192(3);462-7. PMID: 4904678

Bairoch93a: Bairoch A, Boeckmann B (1993). "The SWISS-PROT protein sequence data bank, recent developments." Nucleic Acids Res. 21:3093-3096. PMID: 8332529

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.5 on Fri Nov 27, 2015, BIOCYC13B.