MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:
γ-glutamyl kinase Inferred from experiment : proB ( Escherichia coli K-12 substr. MG1655 )
δ-1-pyrroline-5-carboxylate synthase Inferred from experiment : ALDH18A1 ( Homo sapiens )

In Pathway: L-citrulline biosynthesis , L-ornithine de novo biosynthesis , L-proline biosynthesis I

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: glutamate 5-kinase

Enzyme Commission Synonyms: ATP-L-glutamate 5-phosphotransferase, ATP:γ-L-glutamate phosphotransferase, γ-glutamate kinase, γ-glutamyl kinase, glutamate kinase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 8.53833 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This is the first step in the proline biosynthesis pathway.

The product rapidly cyclizes to 5-oxoproline and orthophosphate. [Bairoch93a]

Citations: [Baich69]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: KEGG:R00239 , Rhea:14877

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC: , UniProt:RELATED-TO:O04226 , UniProt:RELATED-TO:O13810 , UniProt:RELATED-TO:P0A7B5 , UniProt:RELATED-TO:P17856 , UniProt:RELATED-TO:P32264 , UniProt:RELATED-TO:P43763 , UniProt:RELATED-TO:P46546 , UniProt:RELATED-TO:P73071 , UniProt:RELATED-TO:Q9CF72 , UniProt:RELATED-TO:Q9JUK7 , UniProt:RELATED-TO:Q9PJ29


Baich69: Baich A (1969). "Proline synthesis in Escherichia coli. A proline-inhibitable glutamic acid kinase." Biochim Biophys Acta 1969;192(3);462-7. PMID: 4904678

Bairoch93a: Bairoch A, Boeckmann B (1993). "The SWISS-PROT protein sequence data bank, recent developments." Nucleic Acids Res. 21:3093-3096. PMID: 8332529

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Sun Mar 29, 2015, BIOCYC14A.