MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:

Escherichia coli K-12 substr. MG1655 : glutamate-5-semialdehyde dehydrogenase Inferred from experiment : proA
Homo sapiens : δ-1-pyrroline-5-carboxylate synthase Inferred from experiment : ALDH18A1

In Pathway: L-ornithine de novo biosynthesis , L-proline biosynthesis I , L-citrulline biosynthesis

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: glutamate-5-semialdehyde dehydrogenase

Enzyme Commission Synonyms: γ-glutamyl phosphate reductase, β-glutamylphosphate reductase, glutamate semialdehyde dehydrogenase, glutamate-γ-semialdehyde dehydrogenase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 1.7835693 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This is the second step in the proline biosynthesis pathway.

Citations: [Baich71]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: KEGG:R03313 , Rhea:19541

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC: , UniProt:RELATED-TO:O04226 , UniProt:RELATED-TO:P07004 , UniProt:RELATED-TO:P17857 , UniProt:RELATED-TO:P45121 , UniProt:RELATED-TO:P45638 , UniProt:RELATED-TO:P53000 , UniProt:RELATED-TO:P54885 , UniProt:RELATED-TO:Q9JUK8


Baich71: Baich A (1971). "The biosynthesis of proline in Escherichia coli: phosphate-dependent glutamate -semialdehyde dehydrogenase (NADP), the second enzyme in the pathway." Biochim Biophys Acta 244(1);129-34. PMID: 4399189

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Sat Aug 1, 2015, biocyc13.