MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Arabidopsis thaliana col: δ1-pyrroline-5-carboxylate synthetaseInferred from experimentInferred by computational analysis: P5CS1
Escherichia coli K-12 substr. MG1655: glutamate-5-semialdehyde dehydrogenaseInferred from experiment: proA
Homo sapiens: δ-1-pyrroline-5-carboxylate synthaseInferred from experiment: ALDH18A1
Vigna aconitifolia: glutamate-5-semialdehyde dehydrogenaseInferred from experiment: P5CS

In Pathway: L-ornithine biosynthesis II, L-proline biosynthesis I, L-citrulline biosynthesis, L-proline biosynthesis III, L-Nδ-acetylornithine biosynthesis

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: glutamate-5-semialdehyde dehydrogenase

Enzyme Commission Synonyms: γ-glutamyl phosphate reductase, β-glutamylphosphate reductase, glutamate semialdehyde dehydrogenase, glutamate-γ-semialdehyde dehydrogenase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 1.7835693Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This is the second step in the proline biosynthesis pathway.

Citations: [Baich71]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R03313, Rhea:19541

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, UniProt:RELATED-TO:O04226, UniProt:RELATED-TO:P07004, UniProt:RELATED-TO:P17857, UniProt:RELATED-TO:P45121, UniProt:RELATED-TO:P45638, UniProt:RELATED-TO:P53000, UniProt:RELATED-TO:P54885, UniProt:RELATED-TO:Q9JUK8


Baich71: Baich A (1971). "The biosynthesis of proline in Escherichia coli: phosphate-dependent glutamate -semialdehyde dehydrogenase (NADP), the second enzyme in the pathway." Biochim Biophys Acta 244(1);129-34. PMID: 4399189

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.5 on Mon Nov 30, 2015, BIOCYC13B.