MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Arabidopsis thaliana col: glycolate dehydrogenase / D-lactate dehydrogenaseInferred from experiment: AT5G06580
Escherichia coli K-12 substr. MG1655: glycolate oxidaseInferred from experiment: glcD, glcE, glcF
Paracoccus denitrificans NCIMB 8944: glycolate oxidaseInferred from experiment

In Pathway: glycolate and glyoxylate degradation II, glycolate and glyoxylate degradation III, glycolate and glyoxylate degradation I

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: glycolate dehydrogenase

Enzyme Commission Synonyms: glycolate oxidoreductase, glycolic acid dehydrogenase, glycolate:(acceptor) 2-oxidoreductase

Enzyme Commission Summary:
Also acts on (R)-lactate. 2,6-Dichloroindophenol and phenazine methosulfate can act as acceptors.

Citations: [Lord72]

Gene-Reaction Schematic

Gene-Reaction Schematic

Instance reaction of [(R)-lactate + 2 an oxidized c-type cytochrome → pyruvate + 2 a reduced c-type cytochrome + 2 H+] (
i1: (R)-lactate + 2 an oxidized cytochrome c-553 = pyruvate + 2 a reduced cytochrome c-553 + 2 H+ (

Unification Links: KEGG:R00476, Rhea:21264

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Lord72: Lord JM (1972). "Glycolate oxidoreductase in Escherichia coli." Biochim Biophys Acta 1972;267(2);227-37. PMID: 4557653

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.5 on Mon Nov 30, 2015, BIOCYC11A.