Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
twitter

MetaCyc Reaction: 3.2.1.62

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.2.1.62

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Undetermined; a substrate lacks a chemical formula

Enzyme Commission Primary Name: glycosylceramidase

Enzyme Commission Synonyms: phlorizin hydrolase, phloretin-glucosidase, glycosyl ceramide glycosylhydrolase, cerebrosidase, phloridzin β-glucosidase, lactase-phlorizin hydrolase, phloridzin glucosidase

Enzyme Commission Summary:
Broad specificity [cf. EC 3.2.1.45 (glucosylceramidase) and EC 3.2.1.46 (galactosylceramidase)]. Also hydrolyses phlorizin to phloretin and glucose. The intestinal enzyme is a complex that also catalyses the reaction of EC 3.2.1.108 lactase.

Citations: [Malathi69, LorenzMeyer72, Leese73]

Unification Links: KEGG:R01501

Relationship Links: BRENDA:EC:3.2.1.62 , ENZYME:EC:3.2.1.62 , IUBMB-ExplorEnz:EC:3.2.1.62 , UniProt:RELATED-TO:P09848 , UniProt:RELATED-TO:P09849 , UniProt:RELATED-TO:Q02401 , UniProt:RELATED-TO:Q29518 , UniProt:RELATED-TO:Q29519 , UniProt:RELATED-TO:Q29521 , UniProt:RELATED-TO:Q29522


References

Leese73: Leese HJ, Semenza G (1973). "On the identity between the small intestinal enzymes phlorizin hydrolase and glycosylceramidase." J Biol Chem 248(23);8170-3. PMID: 4752949

LorenzMeyer72: Lorenz-Meyer H, Blum AL, Haemmerli HP, Semenza G (1972). "A second enzyme defect in acquired lactase deficiency: lack of small-intestinal phlorizin-hydrolase." Eur J Clin Invest 2(5);326-31. PMID: 5082068

Malathi69: Malathi P, Crane RK (1969). "Phlorizin hydrolase: a beta-glucosidase of hamster intestinal brush border membrane." Biochim Biophys Acta 173(2);245-56. PMID: 5774775


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Wed Nov 26, 2014, biocyc13.