|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 220.127.116.11
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.
Mass balance status: Balance undetermined; a substrate lacks a chemical formula
Enzyme Commission Primary Name: glycosylceramidase
Enzyme Commission Synonyms: phlorizin hydrolase, phloretin-glucosidase, glycosyl ceramide glycosylhydrolase, cerebrosidase, phloridzin β-glucosidase, lactase-phlorizin hydrolase, phloridzin glucosidase
Taxonomic Range: Metazoa
Enzyme Commission Summary:
Broad specificity [cf. EC 18.104.22.168 (glucosylceramidase) and EC 22.214.171.124 (galactosylceramidase)]. Also hydrolyses phlorizin to phloretin and glucose. The intestinal enzyme is a complex that also catalyses the reaction of EC 126.96.36.199 lactase.
Unification Links: KEGG:R01501
Relationship Links: BRENDA:EC:188.8.131.52, ENZYME:EC:184.108.40.206, IUBMB-ExplorEnz:EC:220.127.116.11, UniProt:RELATED-TO:P09848, UniProt:RELATED-TO:P09849, UniProt:RELATED-TO:Q02401, UniProt:RELATED-TO:Q29518, UniProt:RELATED-TO:Q29519, UniProt:RELATED-TO:Q29521, UniProt:RELATED-TO:Q29522
LorenzMeyer72: Lorenz-Meyer H, Blum AL, Haemmerli HP, Semenza G (1972). "A second enzyme defect in acquired lactase deficiency: lack of small-intestinal phlorizin-hydrolase." Eur J Clin Invest 2(5);326-31. PMID: 5082068
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