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MetaCyc Reaction: 3.2.1.62

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.2.1.62

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Mass balance status: Balance undetermined; a substrate lacks a chemical formula

Enzyme Commission Primary Name: glycosylceramidase

Enzyme Commission Synonyms: phlorizin hydrolase, phloretin-glucosidase, glycosyl ceramide glycosylhydrolase, cerebrosidase, phloridzin β-glucosidase, lactase-phlorizin hydrolase, phloridzin glucosidase

Taxonomic Range: Metazoa

Enzyme Commission Summary:
Broad specificity [cf. EC 3.2.1.45 (glucosylceramidase) and EC 3.2.1.46 (galactosylceramidase)]. Also hydrolyses phlorizin to phloretin and glucose. The intestinal enzyme is a complex that also catalyses the reaction of EC 3.2.1.108 lactase.

Citations: [Malathi69, LorenzMeyer72, Leese73]

Unification Links: KEGG:R01501

Relationship Links: BRENDA:EC:3.2.1.62 , ENZYME:EC:3.2.1.62 , IUBMB-ExplorEnz:EC:3.2.1.62 , UniProt:RELATED-TO:P09848 , UniProt:RELATED-TO:P09849 , UniProt:RELATED-TO:Q02401 , UniProt:RELATED-TO:Q29518 , UniProt:RELATED-TO:Q29519 , UniProt:RELATED-TO:Q29521 , UniProt:RELATED-TO:Q29522


References

Leese73: Leese HJ, Semenza G (1973). "On the identity between the small intestinal enzymes phlorizin hydrolase and glycosylceramidase." J Biol Chem 248(23);8170-3. PMID: 4752949

LorenzMeyer72: Lorenz-Meyer H, Blum AL, Haemmerli HP, Semenza G (1972). "A second enzyme defect in acquired lactase deficiency: lack of small-intestinal phlorizin-hydrolase." Eur J Clin Invest 2(5);326-31. PMID: 5082068

Malathi69: Malathi P, Crane RK (1969). "Phlorizin hydrolase: a beta-glucosidase of hamster intestinal brush border membrane." Biochim Biophys Acta 173(2);245-56. PMID: 5774775


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Fri Aug 28, 2015, BIOCYC14A.