|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.168
Enzymes and Genes:
|Escherichia coli K-12 substr. MG1655:||glyoxalase III, Hsp31 molecular chaperone: hchA|
In Pathway: methylglyoxal degradation II
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: D-lactate dehydratase
Enzyme Commission Synonyms: glyoxylase III
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): 16.64711 [Latendresse13]
Enzyme Commission Summary:
The enzyme converts methylglyoxal to D-lactate in a single glutathione (GSH)-independent step. The other known route for this conversion is the two-step GSH-dependent pathway catalysed by EC 22.214.171.124 (lactoylglutathione lyase) and EC 126.96.36.199 (hydroxyacylglutathione hydrolase).
Unification Links: Rhea:27754
Misra95: Misra K, Banerjee AB, Ray S, Ray M (1995). "Glyoxalase III from Escherichia coli: a single novel enzyme for the conversion of methylglyoxal into D-lactate without reduced glutathione." Biochem J 1995;305 ( Pt 3);999-1003. PMID: 7848303
©2015 SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025-3493