Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 4.2.1.130

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 4.2.1.130

Enzymes and Genes:
glyoxalase III, Hsp31 molecular chaperone Inferred from experiment : hchA ( Escherichia coli K-12 substr. MG1655 )

In Pathway: methylglyoxal degradation II

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: D-lactate dehydratase

Enzyme Commission Synonyms: glyoxylase III

Standard Gibbs Free Energy (ΔrG in kcal/mol): 16.64711 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The enzyme converts methylglyoxal to D-lactate in a single glutathione (GSH)-independent step. The other known route for this conversion is the two-step GSH-dependent pathway catalysed by EC 4.4.1.5 (lactoylglutathione lyase) and EC 3.1.2.6 (hydroxyacylglutathione hydrolase).

Citations: [Misra95, Subedi11]

Gene-Reaction Schematic: ?

Unification Links: Rhea:27754

Relationship Links: BRENDA:EC:4.2.1.130 , ENZYME:EC:4.2.1.130 , IUBMB-ExplorEnz:EC:4.2.1.130

Credits:
Revised 25-Aug-2011 by Caspi R , SRI International


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Misra95: Misra K, Banerjee AB, Ray S, Ray M (1995). "Glyoxalase III from Escherichia coli: a single novel enzyme for the conversion of methylglyoxal into D-lactate without reduced glutathione." Biochem J 1995;305 ( Pt 3);999-1003. PMID: 7848303

Subedi11: Subedi KP, Choi D, Kim I, Min B, Park C (2011). "Hsp31 of Escherichia coli K-12 is glyoxalase III." Mol Microbiol 81(4);926-36. PMID: 21696459


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Tue Nov 25, 2014, BIOCYC13A.