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MetaCyc Reaction: 4.2.1.130

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 4.2.1.130

Enzymes and Genes:

Escherichia coli K-12 substr. MG1655 : glyoxalase III, Hsp31 molecular chaperone Inferred from experiment : hchA

In Pathway: methylglyoxal degradation II

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: D-lactate dehydratase

Enzyme Commission Synonyms: glyoxylase III

Standard Gibbs Free Energy (ΔrG in kcal/mol): 16.64711 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The enzyme converts methylglyoxal to D-lactate in a single glutathione (GSH)-independent step. The other known route for this conversion is the two-step GSH-dependent pathway catalysed by EC 4.4.1.5 (lactoylglutathione lyase) and EC 3.1.2.6 (hydroxyacylglutathione hydrolase).

Citations: [Misra95, Subedi11]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: Rhea:27754

Relationship Links: BRENDA:EC:4.2.1.130 , ENZYME:EC:4.2.1.130 , IUBMB-ExplorEnz:EC:4.2.1.130

Credits:
Revised 25-Aug-2011 by Caspi R , SRI International


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Misra95: Misra K, Banerjee AB, Ray S, Ray M (1995). "Glyoxalase III from Escherichia coli: a single novel enzyme for the conversion of methylglyoxal into D-lactate without reduced glutathione." Biochem J 1995;305 ( Pt 3);999-1003. PMID: 7848303

Subedi11: Subedi KP, Choi D, Kim I, Min B, Park C (2011). "Hsp31 of Escherichia coli K-12 is glyoxalase III." Mol Microbiol 81(4);926-36. PMID: 21696459


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Fri Jul 31, 2015, biocyc11.