MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Arabidopsis thaliana col: chloroplastic riboflavin biosynthesis protein ribBAInferred from experiment: RIBBA
Chlamydia trachomatis: GTP cyclohydrolase IIInferred by computational analysis: ribBA
Escherichia coli K-12 substr. MG1655: GTP cyclohydrolase IIInferred from experiment: ribA
Saccharomyces cerevisiae: GTP cyclohydrolase IIInferred from experiment: RIB1

In Pathway: flavin biosynthesis I (bacteria and plants), flavin biosynthesis III (fungi), 6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: GTP cyclohydrolase II

Enzyme Commission Synonyms: guanosine triphosphate cyclohydrolase II, GTP-8-formylhydrolase

Standard Gibbs Free Energy (ΔrG): -96.9801 kcal/molInferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Two C-N bonds are hydrolysed, releasing formate, with simultaneous removal of the terminal diphosphate.

Citations: [Foor75 ]

Gene-Reaction Schematic

Expand/Contract the Schematic connections:

Gene-Reaction Schematic

Unification Links: KEGG:R00425

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, UniProt:RELATED-TO:O08315, UniProt:RELATED-TO:O24019, UniProt:RELATED-TO:O25484, UniProt:RELATED-TO:O66679, UniProt:RELATED-TO:P0A5V0, UniProt:RELATED-TO:P0A7I7, UniProt:RELATED-TO:P0A7I8, UniProt:RELATED-TO:P17620, UniProt:RELATED-TO:P38066, UniProt:RELATED-TO:P43525, UniProt:RELATED-TO:P50139, UniProt:RELATED-TO:P50855, UniProt:RELATED-TO:P51695, UniProt:RELATED-TO:P74104, UniProt:RELATED-TO:Q9PHU4, UniProt:RELATED-TO:Q9PNU4


Foor75: Foor F, Brown GM (1975). "Purification and properties of guanosine triphosphate cyclohydrolase II from Escherichia coli." J Biol Chem 1975;250(9);3545-51. PMID: 235552

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 20.0 (software by SRI International) on Thu May 5, 2016, BIOCYC12.