Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 3.5.4.25

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.5.4.25

Enzymes and Genes:
GTP cyclohydrolase II Inferred from experiment : ribA ( Escherichia coli K-12 substr. MG1655 )
GTP cyclohydrolase II Inferred by computational analysis : ribBA ( Chlamydia trachomatis )
chloroplastic riboflavin biosynthesis protein ribBA Inferred from experiment : RIBBA ( Arabidopsis thaliana col )
GTP cyclohydrolase II Inferred from experiment : RIB1 ( Saccharomyces cerevisiae )

In Pathway: flavin biosynthesis I (bacteria and plants) , flavin biosynthesis III (fungi) , 6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: GTP cyclohydrolase II

Enzyme Commission Synonyms: guanosine triphosphate cyclohydrolase II, GTP-8-formylhydrolase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -96.9801 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Two C-N bonds are hydrolysed, releasing formate, with simultaneous removal of the terminal diphosphate.

Citations: [Foor75]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R00425

Relationship Links: BRENDA:EC:3.5.4.25 , ENZYME:EC:3.5.4.25 , IUBMB-ExplorEnz:EC:3.5.4.25 , UniProt:RELATED-TO:O08315 , UniProt:RELATED-TO:O24019 , UniProt:RELATED-TO:O25484 , UniProt:RELATED-TO:O66679 , UniProt:RELATED-TO:P0A5V0 , UniProt:RELATED-TO:P0A7I7 , UniProt:RELATED-TO:P0A7I8 , UniProt:RELATED-TO:P17620 , UniProt:RELATED-TO:P38066 , UniProt:RELATED-TO:P43525 , UniProt:RELATED-TO:P50139 , UniProt:RELATED-TO:P50855 , UniProt:RELATED-TO:P51695 , UniProt:RELATED-TO:P74104 , UniProt:RELATED-TO:Q9PHU4 , UniProt:RELATED-TO:Q9PNU4


References

Foor75: Foor F, Brown GM (1975). "Purification and properties of guanosine triphosphate cyclohydrolase II from Escherichia coli." J Biol Chem 1975;250(9);3545-51. PMID: 235552

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Mon Nov 24, 2014, biocyc13.