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MetaCyc Reaction: 3.5.4.3

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.5.4.3

Enzymes and Genes:

Camellia sinensis : guanine deaminase Inferred from experiment
Clostridium cylindrosporum : guanine deaminase Inferred from experiment
Drosophila melanogaster : guanine deaminase Inferred from experiment : DhpD
Escherichia coli K-12 substr. MG1655 : guanine deaminase Inferred from experiment : guaD
Halobacterium salinarum : guanine deaminase
Homo sapiens : guanine deaminase Inferred from experiment : GDA

In Pathway: guanosine nucleotides degradation II , guanosine nucleotides degradation III , purine nucleobases degradation I (anaerobic) , purine nucleobases degradation II (anaerobic)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: guanine deaminase

Enzyme Commission Synonyms: guanase, guanine aminase, GAH

Standard Gibbs Free Energy (ΔrG in kcal/mol): -4.1229954 Inferred by computational analysis [Latendresse13]

Citations: [Rabinowitz56a, Hitchings44]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: KEGG:R01676 , Rhea:14665

Relationship Links: BRENDA:EC:3.5.4.3 , ENZYME:EC:3.5.4.3 , IUBMB-ExplorEnz:EC:3.5.4.3


References

Hitchings44: Hitchings GH, Falco EA (1944). "The Identification of Guanine in Extracts of Girella Nigricans: The Specificity of Guanase." Proc Natl Acad Sci U S A 30(10);294-7. PMID: 16578130

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Rabinowitz56a: Rabinowitz, JC, Barker, HA (1956). "Purine fermentation by Clostridium cylindrosporum. II. Purine transformations." J Biol Chem 218(1);161-73. PMID: 13278325


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Sun Aug 30, 2015, biocyc13.