MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Camellia sinensis: guanine deaminaseInferred from experiment
Clostridium cylindrosporum: guanine deaminaseInferred from experiment
Drosophila melanogaster: guanine deaminaseInferred from experiment: DhpD
Escherichia coli K-12 substr. MG1655: guanine deaminaseInferred from experiment: guaD
Halobacterium salinarum: guanine deaminase
Homo sapiens: guanine deaminaseInferred from experiment: GDA

In Pathway: guanosine nucleotides degradation II, guanosine nucleotides degradation III, purine nucleobases degradation I (anaerobic), purine nucleobases degradation II (anaerobic)

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: guanine deaminase

Enzyme Commission Synonyms: guanase, guanine aminase, GAH

Standard Gibbs Free Energy (ΔrG in kcal/mol): -4.1229954Inferred by computational analysis [Latendresse13]

Citations: [Rabinowitz56 , Hitchings44]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R01676, Rhea:14665

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Hitchings44: Hitchings GH, Falco EA (1944). "The Identification of Guanine in Extracts of Girella Nigricans: The Specificity of Guanase." Proc Natl Acad Sci U S A 30(10);294-7. PMID: 16578130

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Rabinowitz56: Rabinowitz, JC, Barker, HA (1956). "Purine fermentation by Clostridium cylindrosporum. II. Purine transformations." J Biol Chem 218(1);161-73. PMID: 13278325

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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