Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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MetaCyc Reaction: 3.8.1.3

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.8.1.3

Enzymes and Genes:
fluoroacetate dehalogenase Inferred from experiment : fac-dex ( Burkholderia sp. )

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Instance reaction:
chloroacetate + H2O → glycolate + chloride + H+ (3.8.1.3)

Enzyme Commission Primary Name: haloacetate dehalogenase

Enzyme Commission Synonyms: monohaloacetate dehalogenase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 21.655128 Inferred by computational analysis [Latendresse13]

Citations: [Goldman65, Goldman66]

Gene-Reaction Schematic: ?

Instance reaction of [a haloacetate + H2O = glycolate + a halide anion + H+] (3.8.1.3):
i1: chloroacetate + H2O → glycolate + chloride + H+ (3.8.1.3)

Unification Links: KEGG:R02336

Relationship Links: BRENDA:EC:3.8.1.3 , ENZYME:EC:3.8.1.3 , IUBMB-ExplorEnz:EC:3.8.1.3


References

Goldman65: Goldman P (1965). "The enzymatic cleavage of the carbon-fluorine bond in fluoroacetate." J Biol Chem 240;3434-8. PMID: 14321384

Goldman66: Goldman P, Milne GW (1966). "Carbon-fluorine bond cleavage. II. Studies on the mechanism of the defluorination of fluoroacetate." J Biol Chem 241(23);5557-9. PMID: 5928195

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sun Dec 21, 2014, biocyc13.