MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Burkholderia sp.: fluoroacetate dehalogenaseInferred from experiment: fac-dex

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Instance reaction:
chloroacetate + H2O → glycolate + chloride + H+ (

Enzyme Commission Primary Name: haloacetate dehalogenase

Enzyme Commission Synonyms: monohaloacetate dehalogenase

Taxonomic Range: Bacteria

Standard Gibbs Free Energy (ΔrG in kcal/mol): 21.655128Inferred by computational analysis [Latendresse13]

Citations: [Goldman65, Goldman66 ]

Gene-Reaction Schematic

Gene-Reaction Schematic

Instance reaction of [a haloacetate + H2O = glycolate + a halide anion + H+] (
i1: chloroacetate + H2O → glycolate + chloride + H+ (

Unification Links: KEGG:R02336

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Goldman65: Goldman P (1965). "The enzymatic cleavage of the carbon-fluorine bond in fluoroacetate." J Biol Chem 240;3434-8. PMID: 14321384

Goldman66: Goldman P, Milne GW (1966). "Carbon-fluorine bond cleavage. II. Studies on the mechanism of the defluorination of fluoroacetate." J Biol Chem 241(23);5557-9. PMID: 5928195

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.5 on Mon Nov 30, 2015, BIOCYC13B.