Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 4.1.1.48

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 4.1.1.48

Enzymes and Genes:
indole-3-glycerol phosphate synthase Inferred from experiment : trpC ( Escherichia coli K-12 substr. MG1655 )
indole-3-glycerol phosphate synthase Inferred from experiment : trpC ( Sulfolobus solfataricus )
indole-3-glycerol phosphate synthase Inferred from experiment : trpC ( Thermococcus kodakarensis )
indole-3-glycerol phosphate synthase Inferred from experiment : trpC ( Thermotoga maritima )

In Pathway: tryptophan biosynthesis

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: indole-3-glycerol-phosphate synthase

Enzyme Commission Synonyms: indoleglycerol phosphate synθse, indoleglycerol phosphate synthase, indole-3-glycerophosphate synthase, 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase (cyclizing)

Standard Gibbs Free Energy (ΔrG in kcal/mol): -34.453613 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
In some organisms, this enzyme is part of a multifunctional protein, together with one or more other components of the system for the biosynthesis of tryptophan [EC 2.4.2.18 (anthranilate phosphoribosyltransferase), EC 4.1.3.27 (anthranilate synthase), EC 4.2.1.20 (tryptophan synthase) and EC 5.3.1.24 (phosphoribosylanthranilate isomerase)].

Citations: [Creighton66, Hutter86]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R03508 , Rhea:23476

Relationship Links: BRENDA:EC:4.1.1.48 , ENZYME:EC:4.1.1.48 , IUBMB-ExplorEnz:EC:4.1.1.48 , UniProt:RELATED-TO:P00908 , UniProt:RELATED-TO:P00909 , UniProt:RELATED-TO:P00910 , UniProt:RELATED-TO:P00911 , UniProt:RELATED-TO:P00937 , UniProt:RELATED-TO:P03964 , UniProt:RELATED-TO:P05328 , UniProt:RELATED-TO:P06531 , UniProt:RELATED-TO:P17217 , UniProt:RELATED-TO:P18304 , UniProt:RELATED-TO:P18483 , UniProt:RELATED-TO:P20409 , UniProt:RELATED-TO:P20577 , UniProt:RELATED-TO:P20578 , UniProt:RELATED-TO:P24773 , UniProt:RELATED-TO:P25170 , UniProt:RELATED-TO:P26938 , UniProt:RELATED-TO:P42393 , UniProt:RELATED-TO:P94327 , UniProt:RELATED-TO:Q92370 , UniProt:RELATED-TO:Q9JSN4 , UniProt:RELATED-TO:Q9PI11 , UniProt:RELATED-TO:Q9S591 , UniProt:RELATED-TO:Q9V1G3 , UniProt:RELATED-TO:Q9X7C7 , UniProt:RELATED-TO:Q9YGB5 , UniProt:RELATED-TO:Q9ZFA7 , UniProt:RELATED-TO:Q01999 , UniProt:RELATED-TO:Q06121 , UniProt:RELATED-TO:Q58328


References

Creighton66: Creighton TE, Yanofsky C (1966). "Indole-3-glycerol phosphate synthetase of Escherichia coli, an enzyme of the tryptophan operon." J Biol Chem 241(20);4616-24. PMID: 5332729

Hutter86: Hutter R, Niederberger P, DeMoss JA (1986). "Tryptophan biosynthetic genes in eukaryotic microorganisms." Annu Rev Microbiol 40;55-77. PMID: 3535653

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Thu Dec 18, 2014, BIOCYC14A.