MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Escherichia coli K-12 substr. MG1655: indole-3-glycerol phosphate synthaseInferred from experiment: trpC
Sulfolobus solfataricus: indole-3-glycerol phosphate synthaseInferred from experiment: trpC
Thermococcus kodakarensis: indole-3-glycerol phosphate synthaseInferred from experiment: trpC
Thermotoga maritima: indole-3-glycerol phosphate synthaseInferred from experiment: trpC

In Pathway: L-tryptophan biosynthesis

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: indole-3-glycerol-phosphate synthase

Enzyme Commission Synonyms: indoleglycerol phosphate synthetase, indoleglycerol phosphate synthase, indole-3-glycerophosphate synthase, 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase (cyclizing)

Standard Gibbs Free Energy (ΔrG in kcal/mol): -34.453613Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
In some organisms, this enzyme is part of a multifunctional protein, together with one or more other components of the system for the biosynthesis of tryptophan [ EC (anthranilate phosphoribosyltransferase), EC (anthranilate synthase), EC (tryptophan synthase) and EC (phosphoribosylanthranilate isomerase)].

Citations: [Creighton66, Hutter86]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R03508, Rhea:23476

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, UniProt:RELATED-TO:P00908, UniProt:RELATED-TO:P00909, UniProt:RELATED-TO:P00910, UniProt:RELATED-TO:P00911, UniProt:RELATED-TO:P00937, UniProt:RELATED-TO:P03964, UniProt:RELATED-TO:P05328, UniProt:RELATED-TO:P06531, UniProt:RELATED-TO:P17217, UniProt:RELATED-TO:P18304, UniProt:RELATED-TO:P18483, UniProt:RELATED-TO:P20409, UniProt:RELATED-TO:P20577, UniProt:RELATED-TO:P20578, UniProt:RELATED-TO:P24773, UniProt:RELATED-TO:P25170, UniProt:RELATED-TO:P26938, UniProt:RELATED-TO:P42393, UniProt:RELATED-TO:P94327, UniProt:RELATED-TO:Q92370, UniProt:RELATED-TO:Q9JSN4, UniProt:RELATED-TO:Q9PI11, UniProt:RELATED-TO:Q9S591, UniProt:RELATED-TO:Q9V1G3, UniProt:RELATED-TO:Q9X7C7, UniProt:RELATED-TO:Q9YGB5, UniProt:RELATED-TO:Q9ZFA7, UniProt:RELATED-TO:Q01999, UniProt:RELATED-TO:Q06121, UniProt:RELATED-TO:Q58328


Creighton66: Creighton TE, Yanofsky C (1966). "Indole-3-glycerol phosphate synthetase of Escherichia coli, an enzyme of the tryptophan operon." J Biol Chem 241(20);4616-24. PMID: 5332729

Hutter86: Hutter R, Niederberger P, DeMoss JA (1986). "Tryptophan biosynthetic genes in eukaryotic microorganisms." Annu Rev Microbiol 40;55-77. PMID: 3535653

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Wed Nov 25, 2015, biocyc12.