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MetaCyc Reaction: 2.6.1.16

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.6.1.16

Enzymes and Genes:

Arabidopsis thaliana col : glucosamine:fructose-6-phosphate aminotransferase Inferred from experiment Inferred by computational analysis : GFAT
Campylobacter jejuni jejuni NCTC 11168 = ATCC 700819 : D-glucosamine-6-phosphate synthase Inferred from experiment : ptmF , ptmA
Candida albicans : glucosamine-6-phosphate synthase Inferred from experiment : GFA1
Drosophila melanogaster : glucosamine-fructose-6-phosphate aminotransferase Inferred from experiment : Gfat1
Escherichia coli K-12 substr. MG1655 : L-glutamine:D-fructose-6-phosphate aminotransferase Inferred from experiment : glmS
Homo sapiens : glutamine:fructose-6-phosphate amidotransferase I Inferred from experiment : GFPT1
Rattus norvegicus : glutamine:fructose-6-phosphate amidotransferase Inferred from experiment : Gfpt1

In Pathway: UDP-N-acetyl-D-glucosamine biosynthesis II , CMP-legionaminate biosynthesis I , UDP-N-acetyl-D-glucosamine biosynthesis I

Supersedes EC number: 5.3.1.19

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Enzyme Commission Primary Name: glutamine—fructose-6-phosphate transaminase (isomerizing)

Enzyme Commission Synonyms: hexosephosphate aminotransferase, glucosamine-6-phosphate isomerase (glutamine-forming), glutamine-fructose-6-phosphate transaminase (isomerizing), D-fructose-6-phosphate amidotransferase, glucosaminephosphate isomerase, glucosamine 6-phosphate synthase, GlcN6P synthase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -3.4358826 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Although the overall reaction is that of a transferase, the mechanism involves the formation of ketimine between fructose 6-phosphate and a 6-amino group from a lysine residue at the active site, which is subsequently displaced by ammonia (transamidination).

Citations: [Teplyakov99, Leloir53, Gryder60, Ghosh60]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: KEGG:R00768 , Rhea:13237

Relationship Links: BRENDA:EC:2.6.1.16 , ENZYME:EC:2.6.1.16 , IUBMB-ExplorEnz:EC:2.6.1.16 , UniProt:RELATED-TO:O19908 , UniProt:RELATED-TO:O26060 , UniProt:RELATED-TO:O26273 , UniProt:RELATED-TO:O66648 , UniProt:RELATED-TO:O83833 , UniProt:RELATED-TO:O84823 , UniProt:RELATED-TO:O86781 , UniProt:RELATED-TO:P08633 , UniProt:RELATED-TO:P0A588 , UniProt:RELATED-TO:P14742 , UniProt:RELATED-TO:P17169 , UniProt:RELATED-TO:P25195 , UniProt:RELATED-TO:P39754 , UniProt:RELATED-TO:P40831 , UniProt:RELATED-TO:P44708 , UniProt:RELATED-TO:P47856 , UniProt:RELATED-TO:P53704 , UniProt:RELATED-TO:P72720 , UniProt:RELATED-TO:Q9JWN9 , UniProt:RELATED-TO:Q9K1P9 , UniProt:RELATED-TO:Q9PLA4 , UniProt:RELATED-TO:Q9PMT4 , UniProt:RELATED-TO:Q9RXK9 , UniProt:RELATED-TO:Q9S168 , UniProt:RELATED-TO:Q9V249 , UniProt:RELATED-TO:Q9WXZ5 , UniProt:RELATED-TO:Q9Z6U0 , UniProt:RELATED-TO:Q9ZJ94 , UniProt:RELATED-TO:Q06210 , UniProt:RELATED-TO:Q09740 , UniProt:RELATED-TO:Q19130 , UniProt:RELATED-TO:Q19699 , UniProt:RELATED-TO:Q56206 , UniProt:RELATED-TO:Q56275 , UniProt:RELATED-TO:Q58815 , UniProt:RELATED-TO:Q84421


References

Ghosh60: Ghosh S, Blumenthal HJ, Davidson E, Roseman S (1960). "Glucosamine metabolism. V. Enzymatic synthesis of glucosamine 6-phosphate." J Biol Chem 235;1265-73. PMID: 13827775

Gryder60: Gryder RM, Pogell BM (1960). "Further studies on glucosamine 6-phosphate synthesis by rat liver enzymes." J Biol Chem 235;558-62. PMID: 13829889

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Leloir53: Leloir LF, Cardini CE (1953). "The biosynthesis of glucosamine." Biochim Biophys Acta 12(1-2);15-22. PMID: 13115409

Teplyakov99: Teplyakov A, Obmolova G, Badet-Denisot MA, Badet B (1999). "The mechanism of sugar phosphate isomerization by glucosamine 6-phosphate synthase." Protein Sci 8(3);596-602. PMID: 10091662


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Fri Sep 4, 2015, biocyc13.