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MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Escherichia coli K-12 substr. MG1655: multifunctional acyl-CoA thioesterase I and protease I and lysophospholipase L1Inferred from experiment: tesA
Saccharomyces cerevisiae: Neuropathy Target Esterase: NTE1
phospholipase B/lyso-phospholipase: PLB1
phospholipase B/lyso-phospholipase: PLB2
phospholipase B: PLB3

Reaction Locations: periplasm (sensu Gram-negative Bacteria)

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: lysophospholipase

Enzyme Commission Synonyms: lecithinase B, lysolecithinase, phospholipase B, lysophosphatidase, lecitholipase, phosphatidase B, lysophosphatidylcholine hydrolase, lysophospholipase A1, lysophopholipase L2, lysophospholipase transacylase, neuropathy target esterase, NTE, NTE-LysoPLA, NTE-lysophospholipase

Taxonomic Range: Fungi, Metazoa, Bacteria

Standard Gibbs Free Energy (ΔrG in kcal/mol): 192.38416Inferred by computational analysis [Latendresse13]

Citations: [vanTienhoven02, vandenBosch81, vandenBosch73, Shapiro53, Dawson58, Quistad03, Lush98, Winrow03]

Gene-Reaction Schematic

Gene-Reaction Schematic

Instance reactions of [a 2,3,4-saturated fatty acyl CoA + H2O → a 2,3,4-saturated fatty acid + coenzyme A + H+] (
i1: palmitoyl-CoA + H2O → palmitate + coenzyme A + H+ (

i2: stearoyl-CoA + H2O → stearate + coenzyme A + H+ (

i3: lauroyl-CoA + H2O → laurate + coenzyme A + H+ (

i4: decanoyl-CoA + H2O → decanoate + coenzyme A + H+ (

i5: myristoyl-CoA + H2O → myristate + coenzyme A + H+ (

i6: icosanoyl-CoA + H2O → arachidate + coenzyme A + H+ (

Unification Links: KEGG:R02746, KEGG:R07291, Rhea:15177

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, UniProt:RELATED-TO:O07427, UniProt:RELATED-TO:O42970, UniProt:RELATED-TO:P07000, UniProt:RELATED-TO:P0ADA1, UniProt:RELATED-TO:P39457, UniProt:RELATED-TO:P53541, UniProt:RELATED-TO:P78854, UniProt:RELATED-TO:Q7M3V3, UniProt:RELATED-TO:Q9P327, UniProt:RELATED-TO:Q03674


Dawson58: Dawson RM (1958). "Studies on the hydrolysis of lecithin by a Penicillium notatum phospholipase B preparation." Biochem J 70(4);559-70. PMID: 13607409

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Lush98: Lush MJ, Li Y, Read DJ, Willis AC, Glynn P (1998). "Neuropathy target esterase and a homologous Drosophila neurodegeneration-associated mutant protein contain a novel domain conserved from bacteria to man." Biochem J 332 ( Pt 1);1-4. PMID: 9576844

Quistad03: Quistad GB, Barlow C, Winrow CJ, Sparks SE, Casida JE (2003). "Evidence that mouse brain neuropathy target esterase is a lysophospholipase." Proc Natl Acad Sci U S A 100(13);7983-7. PMID: 12805562

Shapiro53: Shapiro B (1953). "Purification and properties of a lysolecithinase from pancreas." Biochem J 53(4);663-6. PMID: 13032127

vandenBosch73: van den Bosch H, Aarsman AJ, de Jong JG, van Deenem LL (1973). "Studies on lysophospholipases. I. Purification and some properties of a lysophospholipase from beef pancreas." Biochim Biophys Acta 296(1);94-104. PMID: 4693514

vandenBosch81: van den Bosch H, Vianen GM, van Heusden GP (1981). "Lysophospholipase--transacylase from rat lung." Methods Enzymol 71 Pt C;513-21. PMID: 7278668

vanTienhoven02: van Tienhoven M, Atkins J, Li Y, Glynn P (2002). "Human neuropathy target esterase catalyzes hydrolysis of membrane lipids." J Biol Chem 277(23);20942-8. PMID: 11927584

Winrow03: Winrow CJ, Hemming ML, Allen DM, Quistad GB, Casida JE, Barlow C (2003). "Loss of neuropathy target esterase in mice links organophosphate exposure to hyperactivity." Nat Genet 33(4);477-85. PMID: 12640454

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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