|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions → Protein-Modification Reactions|
|Reactions Classified By Substrate → Macromolecule Reactions → Protein-Reactions → Protein-Modification Reactions|
EC Number: 22.214.171.1248
Enzymes and Genes:
|Moorella thermoacetica :||methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase
In Pathway: reductive acetyl coenzyme A pathway
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: 5-methyltetrahydrofolate:corrinoid/iron-sulfur protein Co-methyltransferase
Enzyme Commission Synonyms: acsE (gene name)
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): 16.661118 [Latendresse13]
Enzyme Commission Summary:
Catalyses the transfer of a methyl group from the N5 group of methyltetrahydrofolate to the 5-methoxybenzimidazolylcobamide cofactor of a corrinoid/Fe-S protein. Involved, together with EC 126.96.36.199, carbon-monoxide dehydrogenase (ferredoxin) and EC 188.8.131.52, CO-methylating acetyl-CoA synthase, in the reductive acetyl coenzyme A (Wood-Ljungdahl) pathway of autotrophic carbon fixation in various bacteria and archaea.
Doukov07: Doukov TI, Hemmi H, Drennan CL, Ragsdale SW (2007). "Structural and kinetic evidence for an extended hydrogen-bonding network in catalysis of methyl group transfer. Role of an active site asparagine residue in activation of methyl transfer by methyltransferases." J Biol Chem 282(9);6609-18. PMID: 17172470
Roberts94: Roberts DL, Zhao S, Doukov T, Ragsdale SW (1994). "The reductive acetyl coenzyme A pathway: sequence and heterologous expression of active methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase from Clostridium thermoaceticum." J Bacteriol 176(19);6127-30. PMID: 7928975
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