Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 2.1.1.258

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Protein-Modification Reactions
Reactions Classified By Substrate Macromolecule Reactions Protein-Reactions Protein-Modification Reactions

EC Number: 2.1.1.258

Enzymes and Genes:
methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase Inferred from experiment : acsE ( Moorella thermoacetica )

In Pathway: reductive acetyl coenzyme A pathway

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Undetermined; a substrate lacks a chemical formula

Enzyme Commission Primary Name: 5-methyltetrahydrofolate:corrinoid/iron-sulfur protein Co-methyltransferase

Enzyme Commission Synonyms: acsE (gene name)

Enzyme Commission Summary:
Catalyses the transfer of a methyl group from the N5 group of methyltetrahydrofolate to the 5-methoxybenzimidazolylcobamide cofactor of a corrinoid/Fe-S protein. Involved, together with EC 1.2.7.4, carbon-monoxide dehydrogenase (ferredoxin) and EC 2.3.1.169, CO-methylating acetyl-CoA synthase, in the reductive acetyl coenzyme A (Wood-Ljungdahl) pathway of autotrophic carbon fixation in various bacteria and archaea.

Citations: [Roberts94, Doukov00, Doukov07]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:2.1.1.258 , ENZYME:EC:2.1.1.258 , IUBMB-ExplorEnz:EC:2.1.1.258

Credits:
Revised 04-Sep-2012 by Caspi R , SRI International


References

Doukov00: Doukov T, Seravalli J, Stezowski JJ, Ragsdale SW (2000). "Crystal structure of a methyltetrahydrofolate- and corrinoid-dependent methyltransferase." Structure 8(8);817-30. PMID: 10997901

Doukov07: Doukov TI, Hemmi H, Drennan CL, Ragsdale SW (2007). "Structural and kinetic evidence for an extended hydrogen-bonding network in catalysis of methyl group transfer. Role of an active site asparagine residue in activation of methyl transfer by methyltransferases." J Biol Chem 282(9);6609-18. PMID: 17172470

Roberts94: Roberts DL, Zhao S, Doukov T, Ragsdale SW (1994). "The reductive acetyl coenzyme A pathway: sequence and heterologous expression of active methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase from Clostridium thermoaceticum." J Bacteriol 176(19);6127-30. PMID: 7928975


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Thu Nov 27, 2014, BIOCYC13A.