|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.168
Enzymes and Genes:
muconate cycloisomerase : catB ( Pseudomonas reinekei )
muconate cycloisomerase I : salC ( Pseudomonas reinekei )
chloromuconate cycloisomerase ( Cupriavidus sp. PS12 )
muconate cycloisomerase : catB ( Pseudomonas putida )
In Pathway: catechol degradation to β-ketoadipate
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: muconate cycloisomerase
Enzyme Commission Synonyms: muconate cycloisomerase I, cis,cis-muconate-lactonizing enzyme, cis,cis-muconate cycloisomerase, muconate lactonizing enzyme, 4-carboxymethyl-4-hydroxyisocrotonolactone lyase (decyclizing), CatB, MCI
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -1.4282227 [Latendresse13]
Enzyme Commission Summary:
Requires Mn2+. Also acts (in the reverse reaction) on 3-methyl-cis,cis-muconate and, very slowly, on cis,trans-hexadienedioate. Not identical with EC 22.214.171.124 (chloromuconate cycloisomerase) or EC 126.96.36.199 (dichloromuconate cycloisomerase).
Ornston66b: Ornston LN (1966). "The conversion of catechol and protocatechuate to beta-ketoadipate by Pseudomonas putida. 3. Enzymes of the catechol pathway." J Biol Chem 241(16);3795-9. PMID: 5330966
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