|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.168
Enzymes and Genes:
|Mycobacterium bovis:||mycocerosic acid synthase: mas|
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balance undetermined; a substrate has a non-numerical coefficient
Enzyme Commission Primary Name: mycocerosate synthase
Enzyme Commission Synonyms: mycocerosic acid synthase
Enzyme Commission Summary:
The enzyme elongates CoA esters of fatty acids from C6 to C20 by incorporation of methylmalonyl, but not malonyl, residues, to form multimethyl-branched fatty-acyl-CoAs such as 2,4,6,8-tetramethyl-octanoyl-CoA.
Rainwater85: Rainwater DL, Kolattukudy PE (1985). "Fatty acid biosynthesis in Mycobacterium tuberculosis var. bovis Bacillus Calmette-Guerin. Purification and characterization of a novel fatty acid synthase, mycocerosic acid synthase, which elongates n-fatty acyl-CoA with methylmalonyl-CoA." J Biol Chem 260(1);616-23. PMID: 3880746
©2015 SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025-3493