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MetaCyc Reaction: 2.3.1.111

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 2.3.1.111

Enzymes and Genes:

Mycobacterium bovis: mycocerosic acid synthaseInferred from experiment: mas

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balance undetermined; a substrate has a non-numerical coefficient

Enzyme Commission Primary Name: mycocerosate synthase

Enzyme Commission Synonyms: mycocerosic acid synthase

Taxonomic Range: Bacteria

Enzyme Commission Summary:
The enzyme elongates CoA esters of fatty acids from C6 to C20 by incorporation of methylmalonyl, but not malonyl, residues, to form multimethyl-branched fatty-acyl-CoAs such as 2,4,6,8-tetramethyl-octanoyl-CoA.

Citations: [Rainwater85]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R05189, Rhea:10588

Relationship Links: BRENDA:EC:2.3.1.111, ENZYME:EC:2.3.1.111, IUBMB-ExplorEnz:EC:2.3.1.111, UniProt:RELATED-TO:P96291, UniProt:RELATED-TO:Q02251, UniProt:RELATED-TO:Q49624


References

Rainwater85: Rainwater DL, Kolattukudy PE (1985). "Fatty acid biosynthesis in Mycobacterium tuberculosis var. bovis Bacillus Calmette-Guerin. Purification and characterization of a novel fatty acid synthase, mycocerosic acid synthase, which elongates n-fatty acyl-CoA with methylmalonyl-CoA." J Biol Chem 260(1);616-23. PMID: 3880746


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Sun May 1, 2016, biocyc13.