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MetaCyc Reaction: 2.3.1.111

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.3.1.111

Enzymes and Genes:
mycocerosic acid synthase Inferred from experiment : mas ( Mycobacterium bovis )

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Undetermined; a substrate has a non-numerical coefficient

Enzyme Commission Primary Name: mycocerosate synthase

Enzyme Commission Synonyms: mycocerosic acid synthase

Enzyme Commission Summary:
The enzyme elongates CoA esters of fatty acids from C6 to C20 by incorporation of methylmalonyl, but not malonyl, residues, to form multimethyl-branched fatty-acyl-CoAs such as 2,4,6,8-tetramethyl-octanoyl-CoA.

Citations: [Rainwater85]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R05189 , Rhea:10588

Relationship Links: BRENDA:EC:2.3.1.111 , ENZYME:EC:2.3.1.111 , IUBMB-ExplorEnz:EC:2.3.1.111 , UniProt:RELATED-TO:P96291 , UniProt:RELATED-TO:Q02251 , UniProt:RELATED-TO:Q49624


References

Rainwater85: Rainwater DL, Kolattukudy PE (1985). "Fatty acid biosynthesis in Mycobacterium tuberculosis var. bovis Bacillus Calmette-Guerin. Purification and characterization of a novel fatty acid synthase, mycocerosic acid synthase, which elongates n-fatty acyl-CoA with methylmalonyl-CoA." J Biol Chem 260(1);616-23. PMID: 3880746


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sun Feb 1, 2015, biocyc11.