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MetaCyc Reaction: 2.3.1.74

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.3.1.74

Enzymes and Genes:
naringenin-chalcone synthase Inferred from experiment : CHS-A ( Petunia x hybrida )
chalcone synthase Inferred from experiment ( Equisetum arvense )
aromatic polyketide synthase Inferred from experiment : PKS3 ( Rubus idaeus )
aromatic polyketide synthase Inferred from experiment : PKS1 ( Rubus idaeus )
chalcone synthase : PKS ( Cannabis sativa )
naringenin chalcone synthase Inferred from experiment : CHS ( Humulus lupulus )
naringenin chalcone synthase Inferred from experiment : CHS ( Arabidopsis thaliana col )

In Pathway: xanthohumol biosynthesis , aromatic polyketides biosynthesis , flavonoid biosynthesis (in equisetum) , naringenin biosynthesis (engineered) , flavonoid biosynthesis

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: naringenin-chalcone synthase

Enzyme Commission Synonyms: chalcone synthase, flavanone synthase, 6'-deoxychalcone synthase, chalcone synθse, DOCS, CHS

Standard Gibbs Free Energy (ΔrG in kcal/mol): 11.131836 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
In the presence of NADH and a reductase, 6'-deoxychalcone is produced.

Citations: [Ayabe88, Heller80]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R01613 , Rhea:11128

Relationship Links: BRENDA:EC:2.3.1.74 , ENZYME:EC:2.3.1.74 , IUBMB-ExplorEnz:EC:2.3.1.74 , UniProt:RELATED-TO:O04934 , UniProt:RELATED-TO:O04966 , UniProt:RELATED-TO:O04967 , UniProt:RELATED-TO:O04968 , UniProt:RELATED-TO:O04969 , UniProt:RELATED-TO:O04970 , UniProt:RELATED-TO:O04971 , UniProt:RELATED-TO:O22047 , UniProt:RELATED-TO:P06515 , UniProt:RELATED-TO:P08894 , UniProt:RELATED-TO:P13114 , UniProt:RELATED-TO:P13416 , UniProt:RELATED-TO:P13417 , UniProt:RELATED-TO:P16107 , UniProt:RELATED-TO:P17818 , UniProt:RELATED-TO:P17957 , UniProt:RELATED-TO:P19168 , UniProt:RELATED-TO:P22924 , UniProt:RELATED-TO:P22925 , UniProt:RELATED-TO:P22926 , UniProt:RELATED-TO:P22927 , UniProt:RELATED-TO:P22928 , UniProt:RELATED-TO:P23419 , UniProt:RELATED-TO:P23569 , UniProt:RELATED-TO:P24824 , UniProt:RELATED-TO:P24825 , UniProt:RELATED-TO:P24826 , UniProt:RELATED-TO:P26018 , UniProt:RELATED-TO:P30073 , UniProt:RELATED-TO:P30074 , UniProt:RELATED-TO:P30075 , UniProt:RELATED-TO:P30076 , UniProt:RELATED-TO:P30077 , UniProt:RELATED-TO:P30078 , UniProt:RELATED-TO:P30079 , UniProt:RELATED-TO:P30080 , UniProt:RELATED-TO:P30081 , UniProt:RELATED-TO:P48389 , UniProt:RELATED-TO:P48390 , UniProt:RELATED-TO:P48397 , UniProt:RELATED-TO:P48398 , UniProt:RELATED-TO:P48399 , UniProt:RELATED-TO:P48405 , UniProt:RELATED-TO:P48406 , UniProt:RELATED-TO:P51075 , UniProt:RELATED-TO:P51077 , UniProt:RELATED-TO:P51078 , UniProt:RELATED-TO:P51079 , UniProt:RELATED-TO:P51080 , UniProt:RELATED-TO:P51081 , UniProt:RELATED-TO:P51082 , UniProt:RELATED-TO:P51089 , UniProt:RELATED-TO:Q9S9B9 , UniProt:RELATED-TO:Q9S9C0 , UniProt:RELATED-TO:Q01286 , UniProt:RELATED-TO:Q01287 , UniProt:RELATED-TO:Q01288 , UniProt:RELATED-TO:Q40005 , UniProt:RELATED-TO:Q41292 , UniProt:RELATED-TO:Q43188 , UniProt:RELATED-TO:Q96562 , UniProt:RELATED-TO:Q96568

Credits:
Last-Curated ? 12-Apr-2011 by Caspi R , SRI International


References

Ayabe88: Ayabe S, Udagawa A, Furuya T (1988). "NAD(P)H-dependent 6'-deoxychalcone synthase activity in Glycyrrhiza echinata cells induced by yeast extract." Arch Biochem Biophys 261(2);458-62. PMID: 3355160

Heller80: Heller W, Hahlbrock K (1980). "Highly purified "flavanone synthase" from parsley catalyzes the formation of naringenin chalcone." Arch Biochem Biophys 200(2);617-9. PMID: 7436427

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Fri Nov 21, 2014, biocyc14.