Metabolic Modeling Tutorial
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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
BioCyc websites down
12/28 - 12/31
for maintenance.
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MetaCyc Reaction: 1.1.3.28

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Composite Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.1.3.28

Enzymes and Genes:
nucleoside oxidase Inferred from experiment ( Stenotrophomonas maltophilia )

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: nucleoside oxidase

Sub-reactions:
2 inosine + oxygen = 2 5'-dehydroinosine + 2 H2O ,
2 5'-dehydroinosine + oxygen = 2 9-riburonosylhypoxanthine + 2 H+

Standard Gibbs Free Energy (ΔrG in kcal/mol): -113.9811 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Other purine and pyrimidine nucleosides (as well as 2'-deoxynucleosides) are substrates, but ribose and nucleotides are not substrates.

The overall reaction takes place in two separate steps, with the 5'-dehydro nucleoside being released from the enzyme to serve as substrate for the second reaction.

The two reactions are:

2 inosine + oxygen = 2 5'-dehydroinosine + 2 H2O

2 5'-dehydroinosine + oxygen = 2 9-riburonosylhypoxanthine + 2 H+

This enzyme differs from EC 1.1.3.39, nucleoside oxidase (H2O2-forming), as it produces water rather than hydrogen peroxide.

Citations: [Isono89]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R05821

Relationship Links: BRENDA:EC:1.1.3.28 , ENZYME:EC:1.1.3.28 , IUBMB-ExplorEnz:EC:1.1.3.28

Credits:
Revised 05-Aug-2009 by Caspi R , SRI International


References

Isono89: Isono, Y, Sudo, T., Hoshino, M. (1989). "Purification and reaction of a new enzyme, nucleoside oxidase." Agric. Biol. Chem. 53:1663-1669.

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Mon Dec 22, 2014, biocyc13.