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Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store

MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Arabidopsis thaliana col: 4'-phosphopantetheine adenylyltransferaseInferred from experiment: AtCoaD
Escherichia coli K-12 substr. MG1655: phosphopantetheine adenylyltransferaseInferred from experiment: coaD
Homo sapiens: bifunctional coenzyme A synthaseInferred from experiment: COASY
Saccharomyces cerevisiae: pantetheine-phosphate adenylyltransferaseInferred from experiment: CAB4

In Pathway: coenzyme A biosynthesis I, coenzyme A biosynthesis II (mammalian)

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: pantetheine-phosphate adenylyltransferase

Enzyme Commission Synonyms: dephospho-CoA pyrophosphorylase, pantetheine phosphate adenylyltransferase, dephospho-coenzyme A pyrophosphorylase, 3'-dephospho-CoA pyrophosphorylase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -54.05249Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The enzyme from several bacteria (e.g. Escherichia coli, Bacillus subtilis and Haemophilus influenzae) has been shown to be bifunctional and also to possess the activity of EC, glucosamine-1-phosphate N-acetyltransferase.

Citations: [Geerlof99, Martin93, NOVELLI53, HOAGLAND54, Izard99]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R03035, Rhea:19801

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Geerlof99: Geerlof A, Lewendon A, Shaw WV (1999). "Purification and characterization of phosphopantetheine adenylyltransferase from Escherichia coli." J Biol Chem 1999;274(38);27105-11. PMID: 10480925

HOAGLAND54: HOAGLAND MB, NOVELLI GD (1954). "Biosynthesis of coenzyme A from phospho-pantetheine and of pantetheine from pantothenate." J Biol Chem 207(2);767-73. PMID: 13163064

Izard99: Izard T, Geerlof A, Lewendon A, Barker JJ (1999). "Cubic crystals of phosphopantetheine adenylyltransferase from Escherichia coli." Acta Crystallogr D Biol Crystallogr 1999;55 ( Pt 6);1226-8. PMID: 10329792

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Martin93: Martin DP, Drueckhammer DG (1993). "Separate enzymes catalyze the final two steps of coenzyme A biosynthesis in Brevibacterium ammoniagenes: purification of pantetheine phosphate adenylyltransferase." Biochem Biophys Res Commun 192(3);1155-61. PMID: 8389542

NOVELLI53: NOVELLI GD (1953). "Enzymatic synthesis and structure of CoA." Fed Proc 12(3);675-81. PMID: 13107738

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Sat Apr 30, 2016, biocyc13.