Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 2.7.9.2

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.7.9.2

Enzymes and Genes:
phosphoenolpyruvate synthetase Inferred from experiment : ppsA ( Escherichia coli K-12 substr. MG1655 )
pyruvate, water dikinase Inferred from experiment ( Desulfobacter hydrogenophilus )

In Pathway: gluconeogenesis I , reductive TCA cycle I , glycolysis II (from fructose 6-phosphate) , glycolysis I (from glucose 6-phosphate)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: pyruvate, water dikinase

Enzyme Commission Synonyms: pyruvate-water dikinase (phosphorylating), PEP synθse, phosphoenolpyruvate synthase, phoephoenolpyruvate synθse, phosphoenolpyruvic synthase, phosphopyruvate synθse

Standard Gibbs Free Energy (ΔrG in kcal/mol): -9.577148 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A manganese protein.

Citations: [Cooper65, Berman70a, Berman70]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R00199 , Rhea:11364

Relationship Links: BRENDA:EC:2.7.9.2 , ENZYME:EC:2.7.9.2 , IUBMB-ExplorEnz:EC:2.7.9.2 , UniProt:RELATED-TO:O27190 , UniProt:RELATED-TO:O29548 , UniProt:RELATED-TO:O57830 , UniProt:RELATED-TO:O67899 , UniProt:RELATED-TO:O83026 , UniProt:RELATED-TO:P23538 , UniProt:RELATED-TO:P42850 , UniProt:RELATED-TO:P46893 , UniProt:RELATED-TO:P56070 , UniProt:RELATED-TO:Q9JVI5 , UniProt:RELATED-TO:Q9V2H7 , UniProt:RELATED-TO:Q9YEC5 , UniProt:RELATED-TO:Q9ZMV4 , UniProt:RELATED-TO:Q55905 , UniProt:RELATED-TO:Q57962


References

Berman70: Berman KM, Cohn M (1970). "Phosphoenolpyruvate synthetase of Escherichia coli. Purification, some properties, and the role of divalent metal ions." J Biol Chem 245(20);5309-18. PMID: 4319237

Berman70a: Berman KM, Cohn M (1970). "Phosphoenolpyruvate synthetase. Partial reactions studied with adenosine triphosphate analogues and the inorganic phosphate-H2 18O exchange reaction." J Biol Chem 245(20);5319-25. PMID: 4319238

Cooper65: Cooper RA, Kornberg HL (1965). "Net formation of phosphoenolpyruvate from pyruvate by Escherichia coli." Biochim Biophys Acta 104(2);618-20. PMID: 5322808

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Thu Nov 27, 2014, BIOCYC13A.