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Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store

MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Desulfobacter hydrogenophilus: pyruvate, water dikinaseInferred from experiment
Escherichia coli K-12 substr. MG1655: phosphoenolpyruvate synthetaseInferred from experiment: ppsA

In Pathway: reductive TCA cycle I, glycolysis II (from fructose 6-phosphate), glycolysis I (from glucose 6-phosphate), gluconeogenesis I

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: pyruvate, water dikinase

Enzyme Commission Synonyms: pyruvate-water dikinase (phosphorylating), PEP synthetase, phosphoenolpyruvate synthase, phoephoenolpyruvate synthetase, phosphoenolpyruvic synthase, phosphopyruvate synthetase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -9.577148Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A manganese protein.

Citations: [Cooper65, Berman70a, Berman70]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R00199, Rhea:11364

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, UniProt:RELATED-TO:O27190, UniProt:RELATED-TO:O29548, UniProt:RELATED-TO:O57830, UniProt:RELATED-TO:O67899, UniProt:RELATED-TO:O83026, UniProt:RELATED-TO:P23538, UniProt:RELATED-TO:P42850, UniProt:RELATED-TO:P46893, UniProt:RELATED-TO:P56070, UniProt:RELATED-TO:Q9JVI5, UniProt:RELATED-TO:Q9V2H7, UniProt:RELATED-TO:Q9YEC5, UniProt:RELATED-TO:Q9ZMV4, UniProt:RELATED-TO:Q55905, UniProt:RELATED-TO:Q57962


Berman70: Berman KM, Cohn M (1970). "Phosphoenolpyruvate synthetase of Escherichia coli. Purification, some properties, and the role of divalent metal ions." J Biol Chem 245(20);5309-18. PMID: 4319237

Berman70a: Berman KM, Cohn M (1970). "Phosphoenolpyruvate synthetase. Partial reactions studied with adenosine triphosphate analogues and the inorganic phosphate-H2 18O exchange reaction." J Biol Chem 245(20);5319-25. PMID: 4319238

Cooper65: Cooper RA, Kornberg HL (1965). "Net formation of phosphoenolpyruvate from pyruvate by Escherichia coli." Biochim Biophys Acta 104(2);618-20. PMID: 5322808

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Mon May 2, 2016, biocyc14.