MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Protein-Modification Reactions
Reactions Classified By Substrate Macromolecule Reactions Protein-Reactions Protein-Modification Reactions

EC Number:

Supersedes EC number:

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Enzyme Commission Primary Name: peptidyl-glycinamidase

Enzyme Commission Synonyms: carboxyamidase, peptidyl carboxy-amidase, peptidyl-aminoacylamidase, carboxamidopeptidase, peptidyl amino acid amide hydrolase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 50.26848 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The enzyme catalyses the cleavage of C-terminal glycinamide from polypeptides.

Inactivates vasopressin and oxytocin by splitting off glycinamide. Also cleaves ester substrates of trypsin and chymotrypsin. Although glycinamide is by far the preferred leaving group, other aminoacylamides may also be released, e.g. phenylalaninamide. The toad skin enzyme is inhibited by diisopropyl fluorophosphate.

Citations: [Nardacci75, Simmons80]

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Nardacci75: Nardacci NJ, Mukhopadhyay S, Campbell BJ (1975). "Partial purification and characterization of the antidiuretic hormone-inactivating enzyme from renal plasma membranes." Biochim Biophys Acta 377(1);146-57. PMID: 1122284

Simmons80: Simmons WH, Walter R (1980). "Carboxamidopeptidase: purification and characterization of a neurohypophyseal hormone inactivating peptidase from toad skin." Biochemistry 19(1);39-48. PMID: 6766314

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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