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MetaCyc Reaction: 2.3.1.8

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.3.1.8

Enzymes and Genes:

Chlamydomonas reinhardtii : phosphate acetyltransferase Author statement Inferred by computational analysis : PAT2
Clostridium acetobutylicum : phosphotransacetylase Inferred from experiment : pta
Clostridium kluyveri : phosphate acetyltransferase Inferred from experiment : pta
Dasytricha ruminantium : phosphate acetyltransferase Inferred from experiment
Escherichia coli K-12 substr. MG1655 :
Eubacterium oxidoreducens G41 : phosphate acetyltransferase Inferred from experiment
Fusobacterium nucleatum : phosphotransacetylase Inferred from experiment
Gottschalkia acidurici : phosphotransacetylase Inferred from experiment
Lactobacillus sanfranciscensis : phosphotransacetylase Inferred from experiment : pta
Methanosarcina thermophila : phosphotransacetylase Inferred from experiment : pta
Moorella thermoacetica : phosphate acetyltransferase Inferred from experiment
Mycoplasma pneumoniae M129 : phosphate acetyltransferase Inferred from experiment : pta
Paracoccus denitrificans NKNIS : phosphate acetyltransferase Inferred from experiment : pta
Pelobacter acetylenicus : phosphate acetyltransferase Inferred from experiment
Roseovarius nubinhibens ISM : phosphate acetyltransferase Inferred from experiment : pta
Salmonella enterica enterica serovar Typhimurium str. LT2 : phosphate propanoyltransferase Inferred from experiment : pduL
Thermotoga maritima : phosphate acetyltransferase Inferred from experiment : pta
[Clostridium] propionicum : phosphotransacetylase Inferred from experiment

In Pathway: pyruvate fermentation to acetate II , heterolactic fermentation , acetylene degradation , acetate formation from acetyl-CoA I , pyruvate fermentation to acetate IV , L-lysine fermentation to acetate and butanoate , sulfoacetaldehyde degradation I , mixed acid fermentation , sulfolactate degradation II , gallate degradation III (anaerobic) , methanogenesis from acetate , superpathway of fermentation (Chlamydomonas reinhardtii) , purine nucleobases degradation II (anaerobic)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: phosphate acetyltransferase

Enzyme Commission Synonyms: phosphotransacetylase, phosphoacylase, PTA

Standard Gibbs Free Energy (ΔrG in kcal/mol): -7.2700195 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Also acts with other short-chain acyl-CoAs.

Citations: [STADTMAN52, Bergmeyer63]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: KEGG:R00230 , Rhea:19521

Relationship Links: BRENDA:EC:2.3.1.8 , ENZYME:EC:2.3.1.8 , IUBMB-ExplorEnz:EC:2.3.1.8 , UniProt:RELATED-TO:P0A9M8 , UniProt:RELATED-TO:P38503 , UniProt:RELATED-TO:P45107 , UniProt:RELATED-TO:P47541 , UniProt:RELATED-TO:P73662 , UniProt:RELATED-TO:P75359 , UniProt:RELATED-TO:Q9CF22 , UniProt:RELATED-TO:Q9PPL9 , UniProt:RELATED-TO:Q9RY77


References

Bergmeyer63: Bergmeyer, H.U., Holz, G., Klotzsch, H., Lang, G. (1963). "[Phosphotransacetylase from Clostridium kluyveri. Culture of the bacterium, isolation, crystallization and properties of the enzyme.]." Biochem Z 338;114-21. PMID: 14087284

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

STADTMAN52: STADTMAN ER (1952). "The purification and properties of phosphotransacetylase." J Biol Chem 196(2);527-34. PMID: 12980995


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Mon Aug 31, 2015, BIOCYC14B.