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MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Chlamydomonas reinhardtii: phosphate acetyltransferaseAuthor statementInferred by computational analysis: PAT2
Clostridium acetobutylicum: phosphotransacetylaseInferred from experiment: pta
Clostridium kluyveri: phosphate acetyltransferaseInferred from experiment: pta
Dasytricha ruminantium: phosphate acetyltransferaseInferred from experiment
Escherichia coli K-12 substr. MG1655:
Eubacterium oxidoreducens G41: phosphate acetyltransferaseInferred from experiment
Fusobacterium nucleatum: phosphotransacetylaseInferred from experiment
Gottschalkia acidurici: phosphotransacetylaseInferred from experiment
Lactobacillus sanfranciscensis: phosphotransacetylaseInferred from experiment: pta
Methanosarcina thermophila: phosphotransacetylaseInferred from experiment: pta
Moorella thermoacetica: phosphate acetyltransferaseInferred from experiment
Mycoplasma pneumoniae M129: phosphate acetyltransferaseInferred from experiment: pta
Paracoccus denitrificans NKNIS: phosphate acetyltransferaseInferred from experiment: pta
Pelobacter acetylenicus: phosphate acetyltransferaseInferred from experiment
Roseovarius nubinhibens ISM: phosphate acetyltransferaseInferred from experiment: pta
Salmonella enterica enterica serovar Typhimurium str. LT2: phosphate propanoyltransferaseInferred from experiment: pduL
Thermotoga maritima: phosphate acetyltransferaseInferred from experiment: pta
[Clostridium] propionicum: phosphotransacetylaseInferred from experiment

In Pathway: pyruvate fermentation to acetate II, acetylene degradation, acetate formation from acetyl-CoA I, pyruvate fermentation to acetate IV, L-lysine fermentation to acetate and butanoate, sulfoacetaldehyde degradation I, mixed acid fermentation, sulfolactate degradation II, gallate degradation III (anaerobic), methanogenesis from acetate, superpathway of fermentation (Chlamydomonas reinhardtii), purine nucleobases degradation II (anaerobic), heterolactic fermentation

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: phosphate acetyltransferase

Enzyme Commission Synonyms: phosphotransacetylase, phosphoacylase, PTA

Standard Gibbs Free Energy (ΔrG in kcal/mol): -7.2700195Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Also acts with other short-chain acyl-CoAs.

Citations: [STADTMAN52, Bergmeyer63]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R00230, Rhea:19521

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, UniProt:RELATED-TO:P0A9M8, UniProt:RELATED-TO:P38503, UniProt:RELATED-TO:P45107, UniProt:RELATED-TO:P47541, UniProt:RELATED-TO:P73662, UniProt:RELATED-TO:P75359, UniProt:RELATED-TO:Q9CF22, UniProt:RELATED-TO:Q9PPL9, UniProt:RELATED-TO:Q9RY77


Bergmeyer63: Bergmeyer, H.U., Holz, G., Klotzsch, H., Lang, G. (1963). "[Phosphotransacetylase from Clostridium kluyveri. Culture of the bacterium, isolation, crystallization and properties of the enzyme.]." Biochem Z 338;114-21. PMID: 14087284

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

STADTMAN52: STADTMAN ER (1952). "The purification and properties of phosphotransacetylase." J Biol Chem 196(2);527-34. PMID: 12980995

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Tue Jan 1, 2002, biocyc12.