MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Arabidopsis thaliana col:
Homo sapiens:

In Pathway: 3-phosphoinositide degradation

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Enzyme Commission Primary Name: phosphoinositide 5-phosphatase

Enzyme Commission Synonyms: type II inositol polyphosphate 5-phosphatase, triphosphoinositide phosphatase, IP3 phosphatase, PtdIns(4,5)P2 phosphatase, triphosphoinositide phosphomonoesterase, diphosphoinositide phosphatase, inositol 1,4,5-triphosphate 5-phosphomonoesterase, inositol triphosphate 5-phosphomonoesterase, phosphatidylinositol-bisphosphatase, phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase, phosphatidylinositol 4,5-bisphosphate phosphatase, polyphosphoinositol lipid 5-phosphatase, phosphatidyl-inositol-bisphosphate phosphatase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 0.6906738Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
These enzymes can also remove the 5-phosphate from Ins(1,4,5)P3 and/or Ins(1,3,4,5)P4. They are a diverse family of enzymes, with differing abilities to catalyse two or more of the four reactions listed. They are thought to use inositol lipids rather than inositol phosphates as substrates in vivo. All of them can use either or both of PtdIns(4,5)P2 and PtdIns(3,4,5)P3 as substrates; this is the main property that distinguishes them from EC, inositol-polyphosphate 5-phosphatase.

Citations: [Roach81, Dawson64]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R04404, Rhea:22764

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Dawson64: Dawson RM, Thompson W (1964). "The triphosphoinositide phosphomonoesterase of brain tissue." Biochem J 91(2);244-50. PMID: 4284485

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Roach81: Roach PD, Palmer FB (1981). "Human erythrocyte cytosol phosphatidyl-inositol-bisphosphate phosphatase." Biochim Biophys Acta 661(2);323-33. PMID: 6271223

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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