|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 220.127.116.11
Enzymes and Genes:
phosphatidyl inositol polyphosphate 5-phosphatase : 5PTase7 ( Arabidopsis thaliana col )
phosphatidylinositol 5-phosphatase : 5PTase11 ( Arabidopsis thaliana col )
phosphatidylinositol/ inositol polyphosphate 5-phosphatase : 5PTase14 ( Arabidopsis thaliana col )
synaptojanin 2 : SYNJ2 ( Homo sapiens )
inositol polyphosphate 5-phosphatase OCRL1 : OCRL ( Homo sapiens )
inositol polyphosphate 5-phosphatase K : INPP5K ( Homo sapiens )
type II inositol-1,4,5-trisphosphate 5-phosphatase : INPP5B ( Homo sapiens )
synaptojanin 1 : SYNJ1 ( Homo sapiens )
type IV inositol polyphosphate 5-phosphatase : INPP5E ( Homo sapiens )
phosphatidylinositol-4,5-bisphosphate 5-phosphatase, A : INPP5J ( Homo sapiens )
phosphatidylinositide phosphatase SAC2 : INPP5F ( Homo sapiens )
In Pathway: 3-phosphoinositide degradation
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.
Mass balance status: Balanced.
Enzyme Commission Primary Name: phosphoinositide 5-phosphatase
Enzyme Commission Synonyms: type II inositol polyphosphate 5-phosphatase, triphosphoinositide phosphatase, IP3 phosphatase, PtdIns(4,5)P2 phosphatase, triphosphoinositide phosphomonoesterase, diphosphoinositide phosphatase, inositol 1,4,5-triphosphate 5-phosphomonoesterase, inositol triphosphate 5-phosphomonoesterase, phosphatidylinositol-bisphosphatase, phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase, phosphatidylinositol 4,5-bisphosphate phosphatase, polyphosphoinositol lipid 5-phosphatase, phosphatidyl-inositol-bisphosphate phosphatase
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): 0.6906738 [Latendresse13]
Enzyme Commission Summary:
These enzymes can also remove the 5-phosphate from Ins(1,4,5)P3 and/or Ins(1,3,4,5)P4. They are a diverse family of enzymes, with differing abilities to catalyse two or more of the four reactions listed. They are thought to use inositol lipids rather than inositol phosphates as substrates in vivo. All of them can use either or both of PtdIns(4,5)P2 and PtdIns(3,4,5)P3 as substrates; this is the main property that distinguishes them from EC 18.104.22.168, inositol-polyphosphate 5-phosphatase.
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