Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 3.1.3.36

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 3.1.3.36

Enzymes and Genes:
phosphatidyl inositol polyphosphate 5-phosphatase Inferred from experiment Inferred by computational analysis : 5PTase7 ( Arabidopsis thaliana col )
phosphatidylinositol 5-phosphatase Inferred from experiment Inferred by computational analysis : 5PTase11 ( Arabidopsis thaliana col )
phosphatidylinositol/ inositol polyphosphate 5-phosphatase Inferred from experiment Inferred by computational analysis : 5PTase14 ( Arabidopsis thaliana col )
synaptojanin 2 Inferred from experiment : SYNJ2 ( Homo sapiens )
inositol polyphosphate 5-phosphatase OCRL1 Inferred from experiment : OCRL ( Homo sapiens )
inositol polyphosphate 5-phosphatase K Inferred from experiment : INPP5K ( Homo sapiens )
type II inositol-1,4,5-trisphosphate 5-phosphatase Inferred from experiment : INPP5B ( Homo sapiens )
synaptojanin 1 Inferred from experiment : SYNJ1 ( Homo sapiens )
type IV inositol polyphosphate 5-phosphatase Inferred from experiment : INPP5E ( Homo sapiens )
phosphatidylinositol-4,5-bisphosphate 5-phosphatase, A Inferred from experiment : INPP5J ( Homo sapiens )
phosphatidylinositide phosphatase SAC2 Inferred from experiment : INPP5F ( Homo sapiens )

In Pathway: 3-phosphoinositide degradation

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: phosphoinositide 5-phosphatase

Enzyme Commission Synonyms: type II inositol polyphosphate 5-phosphatase, triphosphoinositide phosphatase, IP3 phosphatase, PtdIns(4,5)P2 phosphatase, triphosphoinositide phosphomonoesterase, diphosphoinositide phosphatase, inositol 1,4,5-triphosphate 5-phosphomonoesterase, inositol triphosphate 5-phosphomonoesterase, phosphatidylinositol-bisphosphatase, phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase, phosphatidylinositol 4,5-bisphosphate phosphatase, polyphosphoinositol lipid 5-phosphatase, phosphatidyl-inositol-bisphosphate phosphatase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 0.6906738 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
These enzymes can also remove the 5-phosphate from Ins(1,4,5)P3 and/or Ins(1,3,4,5)P4. They are a diverse family of enzymes, with differing abilities to catalyse two or more of the four reactions listed. They are thought to use inositol lipids rather than inositol phosphates as substrates in vivo. All of them can use either or both of PtdIns(4,5)P2 and PtdIns(3,4,5)P3 as substrates; this is the main property that distinguishes them from EC 3.1.3.56, inositol-polyphosphate 5-phosphatase.

Citations: [Roach81, Dawson64]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R04404 , Rhea:22764

Relationship Links: BRENDA:EC:3.1.3.36 , ENZYME:EC:3.1.3.36 , IUBMB-ExplorEnz:EC:3.1.3.36


References

Dawson64: Dawson RM, Thompson W (1964). "The triphosphoinositide phosphomonoesterase of brain tissue." Biochem J 91(2);244-50. PMID: 4284485

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Roach81: Roach PD, Palmer FB (1981). "Human erythrocyte cytosol phosphatidyl-inositol-bisphosphate phosphatase." Biochim Biophys Acta 661(2);323-33. PMID: 6271223


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Thu Nov 27, 2014, biocyc11.