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discounted EARLY registration ends Dec 31, 2014
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discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 2.7.11.1

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Protein-Modification Reactions
Reactions Classified By Substrate Macromolecule Reactions Protein-Reactions Protein-Modification Reactions

EC Number: 2.7.11.1

Enzymes and Genes:
serine/threonine protein kinase Inferred from experiment : rdoA ( Escherichia coli K-12 substr. MG1655 )
protein kinase Inferred from experiment : yeaG ( Escherichia coli K-12 substr. MG1655 )
MAP kinase-activated protein kinase 2 Inferred from experiment : MAPKAPK2 ( Homo sapiens )

Supersedes EC number: 2.7.1.37

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: non-specific serine/threonine protein kinase

Enzyme Commission Synonyms: A-kinase, AP50 kinase, ATP-protein transphosphorylase, calcium-dependent protein kinase C, calcium/phospholipid-dependent protein kinase, cAMP-dependent protein kinase, cAMP-dependent protein kinase A, casein kinase, casein kinase (phosphorylating), casein kinase 2, casein kinase I, casein kinase II, cGMP-dependent protein kinase, CK-2, CKI, CKII, cyclic AMP-dependent protein kinase, cyclic AMP-dependent protein kinase A, cyclic monophosphate-dependent protein kinase, cyclic nucleotide-dependent protein kinase, cyclin-dependent kinase, cytidine 3',5'-cyclic monophosphate-responsive protein kinase, dsk1, glycogen synthase a kinase, glycogen synthase kinase, HIPK2, Hpr kinase, hydroxyalkyl-protein kinase, M phase-specific cdc2 kinase, mitogen-activated S6 kinase, p82 kinase, phosphorylase b kinase kinase, PKA, protein glutamyl kinase, protein kinase (phosphorylating), protein kinase A, protein kinase CK2, protein kinase p58, protein phosphokinase, protein serine kinase, protein serine-threonine kinase, protein-aspartyl kinase, protein-cysteine kinase, protein-serine kinase, Prp4 protein kinase, Raf kinase, Raf-1, ribosomal protein S6 kinase II, ribosomal S6 protein kinase, serine kinase, serine protein kinase, serine-specific protein kinase, serine(threonine) protein kinase, serine/threonine protein kinase, STK32, T-antigen kinase, threonine-specific protein kinase, twitchin kinase, type-2 casein kinase, βIIPKC, ε PKC, Wee 1-like kinase, Wee-kinase, WEE1Hu

Standard Gibbs Free Energy (ΔrG in kcal/mol): -4.544739 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. Formerly EC 2.7.1.37.

Citations: [Wang01a, Gross97, Takeuchi93, Langan69, Jergil70, Baggio70, Damuni88]

Gene-Reaction Schematic: ?

Relationship Links: BRENDA:EC:2.7.11.1 , ENZYME:EC:2.7.11.1 , IUBMB-ExplorEnz:EC:2.7.11.1 , UniProt:RELATED-TO:O08815 , UniProt:RELATED-TO:O09433 , UniProt:RELATED-TO:O09434 , UniProt:RELATED-TO:O10416 , UniProt:RELATED-TO:O22411 , UniProt:RELATED-TO:O22412 , UniProt:RELATED-TO:O39305 , UniProt:RELATED-TO:O49120 , UniProt:RELATED-TO:O54874 , UniProt:RELATED-TO:P00513 , UniProt:RELATED-TO:P00514 , UniProt:RELATED-TO:P00515 , UniProt:RELATED-TO:P00516 , UniProt:RELATED-TO:P00517 , UniProt:RELATED-TO:P00531 , UniProt:RELATED-TO:P00532 , UniProt:RELATED-TO:P00536 , UniProt:RELATED-TO:P00537 , UniProt:RELATED-TO:P00538 , UniProt:RELATED-TO:P00539 , UniProt:RELATED-TO:P00540 , UniProt:RELATED-TO:P00546 , UniProt:RELATED-TO:P04049 , UniProt:RELATED-TO:P04413 , UniProt:RELATED-TO:P04551 , UniProt:RELATED-TO:P05131 , UniProt:RELATED-TO:P05132 , UniProt:RELATED-TO:P05207 , UniProt:RELATED-TO:P05383 , UniProt:RELATED-TO:P05986 , UniProt:RELATED-TO:P05987 , UniProt:RELATED-TO:P06244 , UniProt:RELATED-TO:P06245 , UniProt:RELATED-TO:P06493 , UniProt:RELATED-TO:P06803 , UniProt:RELATED-TO:P07278 , UniProt:RELATED-TO:P07331 , UniProt:RELATED-TO:P07802 , UniProt:RELATED-TO:P08018 , UniProt:RELATED-TO:P09251 , UniProt:RELATED-TO:P09456 , UniProt:RELATED-TO:P10421 , UniProt:RELATED-TO:P10533 , UniProt:RELATED-TO:P10644 , UniProt:RELATED-TO:P10650 , UniProt:RELATED-TO:P10741 , UniProt:RELATED-TO:P11309 , UniProt:RELATED-TO:P11440 , UniProt:RELATED-TO:P11802 , UniProt:RELATED-TO:P12367 , UniProt:RELATED-TO:P12368 , UniProt:RELATED-TO:P12369 , UniProt:RELATED-TO:P12370 , UniProt:RELATED-TO:P12849 , UniProt:RELATED-TO:P12965 , UniProt:RELATED-TO:P13287 , UniProt:RELATED-TO:P13861 , UniProt:RELATED-TO:P13863 , UniProt:RELATED-TO:P14619 , UniProt:RELATED-TO:P16892 , UniProt:RELATED-TO:P16905 , UniProt:RELATED-TO:P16913 , UniProt:RELATED-TO:P17612 , UniProt:RELATED-TO:P17613 , UniProt:RELATED-TO:P18265 , UniProt:RELATED-TO:P18431 , UniProt:RELATED-TO:P19026 , UniProt:RELATED-TO:P20505 , UniProt:RELATED-TO:P21136 , UniProt:RELATED-TO:P21137 , UniProt:RELATED-TO:P21901 , UniProt:RELATED-TO:P22612 , UniProt:RELATED-TO:P22694 , UniProt:RELATED-TO:P23298 , UniProt:RELATED-TO:P23437 , UniProt:RELATED-TO:P24033 , UniProt:RELATED-TO:P24100 , UniProt:RELATED-TO:P24256 , UniProt:RELATED-TO:P24923 , UniProt:RELATED-TO:P24941 , UniProt:RELATED-TO:P25321 , UniProt:RELATED-TO:P25859 , UniProt:RELATED-TO:P26794 , UniProt:RELATED-TO:P27361 , UniProt:RELATED-TO:P27704 , UniProt:RELATED-TO:P27791 , UniProt:RELATED-TO:P27966 , UniProt:RELATED-TO:P28482 , UniProt:RELATED-TO:P28926 , UniProt:RELATED-TO:P29618 , UniProt:RELATED-TO:P29619 , UniProt:RELATED-TO:P29620 , UniProt:RELATED-TO:P30285 , UniProt:RELATED-TO:P30625 , UniProt:RELATED-TO:P31319 , UniProt:RELATED-TO:P31320 , UniProt:RELATED-TO:P31322 , UniProt:RELATED-TO:P31323 , UniProt:RELATED-TO:P31324 , UniProt:RELATED-TO:P31749 , UniProt:RELATED-TO:P31750 , UniProt:RELATED-TO:P31751 , UniProt:RELATED-TO:P32023 , UniProt:RELATED-TO:P32516 , UniProt:RELATED-TO:P32593 , UniProt:RELATED-TO:P33800 , UniProt:RELATED-TO:P34099 , UniProt:RELATED-TO:P34100 , UniProt:RELATED-TO:P34112 , UniProt:RELATED-TO:P34117 , UniProt:RELATED-TO:P34556 , UniProt:RELATED-TO:P35426 , UniProt:RELATED-TO:P35567 , UniProt:RELATED-TO:P36507 , UniProt:RELATED-TO:P36887 , UniProt:RELATED-TO:P36897 , UniProt:RELATED-TO:P38937 , UniProt:RELATED-TO:P38973 , UniProt:RELATED-TO:P39134 , UniProt:RELATED-TO:P39951 , UniProt:RELATED-TO:P40376 , UniProt:RELATED-TO:P41720 , UniProt:RELATED-TO:P43063 , UniProt:RELATED-TO:P43450 , UniProt:RELATED-TO:P47196 , UniProt:RELATED-TO:P47197 , UniProt:RELATED-TO:P48609 , UniProt:RELATED-TO:P49615 , UniProt:RELATED-TO:P49673 , UniProt:RELATED-TO:P50530 , UniProt:RELATED-TO:P50750 , UniProt:RELATED-TO:P51136 , UniProt:RELATED-TO:P51958 , UniProt:RELATED-TO:P54119 , UniProt:RELATED-TO:P54664 , UniProt:RELATED-TO:P54665 , UniProt:RELATED-TO:P54666 , UniProt:RELATED-TO:P54739 , UniProt:RELATED-TO:P54740 , UniProt:RELATED-TO:P62344 , UniProt:RELATED-TO:P63086 , UniProt:RELATED-TO:P68180 , UniProt:RELATED-TO:P68181 , UniProt:RELATED-TO:P68182 , UniProt:RELATED-TO:P81377 , UniProt:RELATED-TO:P97313 , UniProt:RELATED-TO:Q6P5Z2 ... [60 more not displayed]


References

Baggio70: Baggio B, Pinna LA, Moret V, Siliprandi N (1970). "A simple procedure for the purification of rat liver phosvitin kinase." Biochim Biophys Acta 212(3);515-7. PMID: 5456997

Damuni88: Damuni Z, Reed LJ (1988). "Purification and properties of a protamine kinase and a type II casein kinase from bovine kidney mitochondria." Arch Biochem Biophys 262(2);574-84. PMID: 2835010

Gross97: Gross T, Lutzelberger M, Weigmann H, Klingenhoff A, Shenoy S, Kaufer NF (1997). "Functional analysis of the fission yeast Prp4 protein kinase involved in pre-mRNA splicing and isolation of a putative mammalian homologue." Nucleic Acids Res 25(5);1028-35. PMID: 9102632

Jergil70: Jergil B, Dixon GH (1970). "Protamine kinase from rainbow trout testis. Partial purification and characterization." J Biol Chem 245(2);425-34. PMID: 4312674

Langan69: Langan TA (1969). "Action of adenosine 3',5'-monophosphate-dependent histone kinase in vivo." J Biol Chem 244(20);5763-5. PMID: 4310608

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Takeuchi93: Takeuchi M, Yanagida M (1993). "A mitotic role for a novel fission yeast protein kinase dsk1 with cell cycle stage dependent phosphorylation and localization." Mol Biol Cell 4(3);247-60. PMID: 8485317

Wang01a: Wang Y, Hofmann TG, Runkel L, Haaf T, Schaller H, Debatin K, Hug H (2001). "Isolation and characterization of cDNAs for the protein kinase HIPK2." Biochim Biophys Acta 1518(1-2);168-72. PMID: 11267674


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Fri Dec 19, 2014, biocyc13.