MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:

Escherichia coli K-12 substr. MG1655 : ribose-phosphate diphosphokinase Inferred from experiment : prs
Homo sapiens : ribose-phosphate pyrophosphokinase 1 Inferred from experiment : PRPS1
ribose-phosphate pyrophosphokinase 2 Inferred from experiment : PRPS2
ribose-phosphate pyrophosphokinase 3 : PRPS1L1
Mycoplasma pneumoniae M129 : ribose-phosphate pyrophosphokinase Inferred from experiment : prsA

In Pathway: PRPP biosynthesis I

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: ribose-phosphate diphosphokinase

Enzyme Commission Synonyms: ribose-phosphate pyrophosphokinase, PRPP synthetase, phosphoribosylpyrophosphate synthetase, PPRibP synthetase, PP-ribose P synthetase, 5-phosphoribosyl-1-pyrophosphate synthetase, 5-phosphoribose pyrophosphorylase, 5-phosphoribosyl-α-1-pyrophosphate synthetase, phosphoribosyl-diphosphate synthetase, phosphoribosylpyrophosphate synthase, pyrophosphoribosylphosphate synthetase, ribophosphate pyrophosphokinase, ribose-5-phosphate pyrophosphokinase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -25.840576 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
dATP can also act as donor.

Citations: [Switzer69, REMY55, HUGHES52]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: KEGG:R01049 , Rhea:15609

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC: , UniProt:RELATED-TO:O64888 , UniProt:RELATED-TO:O67556 , UniProt:RELATED-TO:P09330 , UniProt:RELATED-TO:P0A1V6 , UniProt:RELATED-TO:P0A717 , UniProt:RELATED-TO:P11908 , UniProt:RELATED-TO:P14193 , UniProt:RELATED-TO:P21108 , UniProt:RELATED-TO:P32895 , UniProt:RELATED-TO:P38063 , UniProt:RELATED-TO:P38620 , UniProt:RELATED-TO:P38689 , UniProt:RELATED-TO:P41831 , UniProt:RELATED-TO:P42816 , UniProt:RELATED-TO:P44328 , UniProt:RELATED-TO:P46585 , UniProt:RELATED-TO:P56184 , UniProt:RELATED-TO:P60891 , UniProt:RELATED-TO:P60892 , UniProt:RELATED-TO:P65235 , UniProt:RELATED-TO:Q93Z66 , UniProt:RELATED-TO:Q9CEI4 , UniProt:RELATED-TO:Q9CHB8 , UniProt:RELATED-TO:Q9PP15 , UniProt:RELATED-TO:Q680A5 , UniProt:RELATED-TO:Q14558 , UniProt:RELATED-TO:Q42581 , UniProt:RELATED-TO:Q42583 , UniProt:RELATED-TO:Q49042 , UniProt:RELATED-TO:Q55848 , UniProt:RELATED-TO:Q59489 , UniProt:RELATED-TO:Q59988 , UniProt:RELATED-TO:Q63468


HUGHES52: HUGHES DE, WILLIAMSON DH (1952). "Some properties of the glutaminase of Clostridium welchii." Biochem J 51(1);45-55. PMID: 14944530

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

REMY55: REMY CN, REMY WT, BUCHANAN JM (1955). "Biosynthesis of the purines. VIII. Enzymatic synthesis and utilization of alpha-5-phosphoribosylpyrophosphate." J Biol Chem 217(2);885-95. PMID: 13271449

Switzer69: Switzer RL (1969). "Regulation and mechanism of phosphoribosylpyrophosphate synthetase. I. Purification and properties of the enzyme from Salmonella typhimurium." J Biol Chem 244(11);2854-63. PMID: 4306285

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Tue Oct 6, 2015, biocyc13.