MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Escherichia coli K-12 substr. MG1655: ribose-phosphate diphosphokinaseInferred from experiment: prs
Homo sapiens: ribose-phosphate pyrophosphokinase 1Inferred from experiment: PRPS1
ribose-phosphate pyrophosphokinase 2Inferred from experiment: PRPS2
ribose-phosphate pyrophosphokinase 3: PRPS1L1
Mycoplasma pneumoniae M129: ribose-phosphate pyrophosphokinaseInferred from experiment: prsA

In Pathway: PRPP biosynthesis I

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: ribose-phosphate diphosphokinase

Enzyme Commission Synonyms: ribose-phosphate pyrophosphokinase, PRPP synthetase, phosphoribosylpyrophosphate synthetase, PPRibP synthetase, PP-ribose P synthetase, 5-phosphoribosyl-1-pyrophosphate synthetase, 5-phosphoribose pyrophosphorylase, 5-phosphoribosyl-α-1-pyrophosphate synthetase, phosphoribosyl-diphosphate synthetase, phosphoribosylpyrophosphate synthase, pyrophosphoribosylphosphate synthetase, ribophosphate pyrophosphokinase, ribose-5-phosphate pyrophosphokinase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -25.840576Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
dATP can also act as donor.

Citations: [Switzer69, REMY55, HUGHES52]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R01049, Rhea:15609

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, UniProt:RELATED-TO:O64888, UniProt:RELATED-TO:O67556, UniProt:RELATED-TO:P09330, UniProt:RELATED-TO:P0A1V6, UniProt:RELATED-TO:P0A717, UniProt:RELATED-TO:P11908, UniProt:RELATED-TO:P14193, UniProt:RELATED-TO:P21108, UniProt:RELATED-TO:P32895, UniProt:RELATED-TO:P38063, UniProt:RELATED-TO:P38620, UniProt:RELATED-TO:P38689, UniProt:RELATED-TO:P41831, UniProt:RELATED-TO:P42816, UniProt:RELATED-TO:P44328, UniProt:RELATED-TO:P46585, UniProt:RELATED-TO:P56184, UniProt:RELATED-TO:P60891, UniProt:RELATED-TO:P60892, UniProt:RELATED-TO:P65235, UniProt:RELATED-TO:Q93Z66, UniProt:RELATED-TO:Q9CEI4, UniProt:RELATED-TO:Q9CHB8, UniProt:RELATED-TO:Q9PP15, UniProt:RELATED-TO:Q680A5, UniProt:RELATED-TO:Q14558, UniProt:RELATED-TO:Q42581, UniProt:RELATED-TO:Q42583, UniProt:RELATED-TO:Q49042, UniProt:RELATED-TO:Q55848, UniProt:RELATED-TO:Q59489, UniProt:RELATED-TO:Q59988, UniProt:RELATED-TO:Q63468


HUGHES52: HUGHES DE, WILLIAMSON DH (1952). "Some properties of the glutaminase of Clostridium welchii." Biochem J 51(1);45-55. PMID: 14944530

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

REMY55: REMY CN, REMY WT, BUCHANAN JM (1955). "Biosynthesis of the purines. VIII. Enzymatic synthesis and utilization of alpha-5-phosphoribosylpyrophosphate." J Biol Chem 217(2);885-95. PMID: 13271449

Switzer69: Switzer RL (1969). "Regulation and mechanism of phosphoribosylpyrophosphate synthetase. I. Purification and properties of the enzyme from Salmonella typhimurium." J Biol Chem 244(11);2854-63. PMID: 4306285

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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