Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014

MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:
ribose-phosphate diphosphokinase Inferred from experiment : prs ( Escherichia coli K-12 substr. MG1655 )
ribose-phosphate pyrophosphokinase 3 : PRPS1L1 ( Homo sapiens )
ribose-phosphate pyrophosphokinase 2 Inferred from experiment : PRPS2 ( Homo sapiens )
ribose-phosphate pyrophosphokinase 1 Inferred from experiment : PRPS1 ( Homo sapiens )
ribose-phosphate pyrophosphokinase Inferred from experiment : prsA ( Mycoplasma pneumoniae M129 )

In Pathway: PRPP biosynthesis I

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: ribose-phosphate diphosphokinase

Enzyme Commission Synonyms: ribose-phosphate pyrophosphokinase, PRPP synθse, phosphoribosylpyrophosphate synθse, PPRibP synθse, PP-ribose P synθse, 5-phosphoribosyl-1-pyrophosphate synθse, 5-phosphoribose pyrophosphorylase, 5-phosphoribosyl-α-1-pyrophosphate synθse, phosphoribosyl-diphosphate synθse, phosphoribosylpyrophosphate synthase, pyrophosphoribosylphosphate synθse, ribophosphate pyrophosphokinase, ribose-5-phosphate pyrophosphokinase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -25.840576 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
dATP can also act as donor.

Citations: [Switzer69, REMY55, HUGHES52]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R01049 , Rhea:15609

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC: , UniProt:RELATED-TO:O64888 , UniProt:RELATED-TO:O67556 , UniProt:RELATED-TO:P09330 , UniProt:RELATED-TO:P0A1V6 , UniProt:RELATED-TO:P0A717 , UniProt:RELATED-TO:P11908 , UniProt:RELATED-TO:P14193 , UniProt:RELATED-TO:P21108 , UniProt:RELATED-TO:P32895 , UniProt:RELATED-TO:P38063 , UniProt:RELATED-TO:P38620 , UniProt:RELATED-TO:P38689 , UniProt:RELATED-TO:P41831 , UniProt:RELATED-TO:P42816 , UniProt:RELATED-TO:P44328 , UniProt:RELATED-TO:P46585 , UniProt:RELATED-TO:P56184 , UniProt:RELATED-TO:P60891 , UniProt:RELATED-TO:P60892 , UniProt:RELATED-TO:P65235 , UniProt:RELATED-TO:Q93Z66 , UniProt:RELATED-TO:Q9CEI4 , UniProt:RELATED-TO:Q9CHB8 , UniProt:RELATED-TO:Q9PP15 , UniProt:RELATED-TO:Q680A5 , UniProt:RELATED-TO:Q14558 , UniProt:RELATED-TO:Q42581 , UniProt:RELATED-TO:Q42583 , UniProt:RELATED-TO:Q49042 , UniProt:RELATED-TO:Q55848 , UniProt:RELATED-TO:Q59489 , UniProt:RELATED-TO:Q59988 , UniProt:RELATED-TO:Q63468


HUGHES52: HUGHES DE, WILLIAMSON DH (1952). "Some properties of the glutaminase of Clostridium welchii." Biochem J 51(1);45-55. PMID: 14944530

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

REMY55: REMY CN, REMY WT, BUCHANAN JM (1955). "Biosynthesis of the purines. VIII. Enzymatic synthesis and utilization of alpha-5-phosphoribosylpyrophosphate." J Biol Chem 217(2);885-95. PMID: 13271449

Switzer69: Switzer RL (1969). "Regulation and mechanism of phosphoribosylpyrophosphate synthetase. I. Purification and properties of the enzyme from Salmonella typhimurium." J Biol Chem 244(11);2854-63. PMID: 4306285

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Thu Dec 18, 2014, BIOCYC14A.