Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
Updated BioCyc iOS App now
available in iTunes store
twitter

MetaCyc Reaction: 2.7.6.1

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 2.7.6.1

Enzymes and Genes:

Escherichia coli K-12 substr. MG1655: ribose-phosphate diphosphokinaseInferred from experiment: prs
Homo sapiens: ribose-phosphate pyrophosphokinase 1Inferred from experiment: PRPS1
ribose-phosphate pyrophosphokinase 2Inferred from experiment: PRPS2
ribose-phosphate pyrophosphokinase 3: PRPS1L1
Mycoplasma pneumoniae M129: ribose-phosphate pyrophosphokinaseInferred from experiment: prsA

In Pathway: PRPP biosynthesis I

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: ribose-phosphate diphosphokinase

Enzyme Commission Synonyms: ribose-phosphate pyrophosphokinase, PRPP synthetase, phosphoribosylpyrophosphate synthetase, PPRibP synthetase, PP-ribose P synthetase, 5-phosphoribosyl-1-pyrophosphate synthetase, 5-phosphoribose pyrophosphorylase, 5-phosphoribosyl-α-1-pyrophosphate synthetase, phosphoribosyl-diphosphate synthetase, phosphoribosylpyrophosphate synthase, pyrophosphoribosylphosphate synthetase, ribophosphate pyrophosphokinase, ribose-5-phosphate pyrophosphokinase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -25.840576Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
dATP can also act as donor.

Citations: [Switzer69, REMY55, HUGHES52]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R01049, Rhea:15609

Relationship Links: BRENDA:EC:2.7.6.1, ENZYME:EC:2.7.6.1, IUBMB-ExplorEnz:EC:2.7.6.1, UniProt:RELATED-TO:O64888, UniProt:RELATED-TO:O67556, UniProt:RELATED-TO:P09330, UniProt:RELATED-TO:P0A1V6, UniProt:RELATED-TO:P0A717, UniProt:RELATED-TO:P11908, UniProt:RELATED-TO:P14193, UniProt:RELATED-TO:P21108, UniProt:RELATED-TO:P32895, UniProt:RELATED-TO:P38063, UniProt:RELATED-TO:P38620, UniProt:RELATED-TO:P38689, UniProt:RELATED-TO:P41831, UniProt:RELATED-TO:P42816, UniProt:RELATED-TO:P44328, UniProt:RELATED-TO:P46585, UniProt:RELATED-TO:P56184, UniProt:RELATED-TO:P60891, UniProt:RELATED-TO:P60892, UniProt:RELATED-TO:P65235, UniProt:RELATED-TO:Q93Z66, UniProt:RELATED-TO:Q9CEI4, UniProt:RELATED-TO:Q9CHB8, UniProt:RELATED-TO:Q9PP15, UniProt:RELATED-TO:Q680A5, UniProt:RELATED-TO:Q14558, UniProt:RELATED-TO:Q42581, UniProt:RELATED-TO:Q42583, UniProt:RELATED-TO:Q49042, UniProt:RELATED-TO:Q55848, UniProt:RELATED-TO:Q59489, UniProt:RELATED-TO:Q59988, UniProt:RELATED-TO:Q63468


References

HUGHES52: HUGHES DE, WILLIAMSON DH (1952). "Some properties of the glutaminase of Clostridium welchii." Biochem J 51(1);45-55. PMID: 14944530

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

REMY55: REMY CN, REMY WT, BUCHANAN JM (1955). "Biosynthesis of the purines. VIII. Enzymatic synthesis and utilization of alpha-5-phosphoribosylpyrophosphate." J Biol Chem 217(2);885-95. PMID: 13271449

Switzer69: Switzer RL (1969). "Regulation and mechanism of phosphoribosylpyrophosphate synthetase. I. Purification and properties of the enzyme from Salmonella typhimurium." J Biol Chem 244(11);2854-63. PMID: 4306285


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Sat Feb 6, 2016, biocyc14.