MetaCyc Reaction: [no EC number assigned]

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Conversion Type Simple Reactions Chemical Reactions Composite Reactions
Reactions Classified By Substrate Small-Molecule Reactions

Enzymes and Genes:
fused PutA DNA-binding transcriptional repressor / proline dehydrogenase / 1-pyrroline-5-carboxylate dehydrogenase : putA ( Escherichia coli K-12 substr. MG1655 )
Δ1-pyrroline-5-carboxylate dehydrogenase, mitochondrial : ALDH4A1 ( Homo sapiens )
1-pyrroline-5-carboxylate dehydrogenase : rocA ( Bacillus subtilis )
Δ1-pyrroline-5-carboxylate dehydrogenase : put2 ( Saccharomyces cerevisiae )
1-pyrroline-5-carboxylate dehydrogenase : At5g62530 ( Arabidopsis thaliana col )
1-pyrroline-5-carboxylate dehydrogenase ( Solanum tuberosum )

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Direct generic reaction:
(S)-1-pyrroline-5-carboxylate + NAD(P)+ + 2 H2O = L-glutamate + NAD(P)H + H+ (no EC#)

(S)-1-pyrroline-5-carboxylate + H+ + H2O ↔ L-glutamate-5-semialdehyde ,
L-glutamate-5-semialdehyde + NAD+ + H2O → L-glutamate + NADH + 2 H+

Standard Gibbs Free Energy (ΔrG in kcal/mol): 7.055786 Inferred by computational analysis [Latendresse13]

Unification Links: KEGG:R00707 , Rhea:16417

Relationship Links: UniProt:RELATED-TO:O24897 , UniProt:RELATED-TO:O74766 , UniProt:RELATED-TO:P07275 , UniProt:RELATED-TO:P09546 , UniProt:RELATED-TO:P10503 , UniProt:RELATED-TO:P74275 , UniProt:RELATED-TO:P95629 , UniProt:RELATED-TO:Q9JSY1 , UniProt:RELATED-TO:Q9K0Z9 , UniProt:RELATED-TO:Q9PMG0 , UniProt:RELATED-TO:Q9ZN12 , UniProt:RELATED-TO:Q59426


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Wed Apr 1, 2015, biocyc13.