|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions → Composite Reactions|
|Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
Enzymes and Genes:
fused PutA DNA-binding transcriptional repressor / proline dehydrogenase / 1-pyrroline-5-carboxylate dehydrogenase : putA ( Escherichia coli K-12 substr. MG1655 )
Δ1-pyrroline-5-carboxylate dehydrogenase, mitochondrial : ALDH4A1 ( Homo sapiens )
1-pyrroline-5-carboxylate dehydrogenase : rocA ( Bacillus subtilis )
Δ1-pyrroline-5-carboxylate dehydrogenase : put2 ( Saccharomyces cerevisiae )
1-pyrroline-5-carboxylate dehydrogenase : At5g62530 ( Arabidopsis thaliana col )
1-pyrroline-5-carboxylate dehydrogenase ( Solanum tuberosum )
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Direct generic reaction:
(S)-1-pyrroline-5-carboxylate + NAD(P)+ + 2 H2O = L-glutamate + NAD(P)H + H+ (no EC#)
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): 7.055786 [Latendresse13]
Relationship Links: UniProt:RELATED-TO:O24897 , UniProt:RELATED-TO:O74766 , UniProt:RELATED-TO:P07275 , UniProt:RELATED-TO:P09546 , UniProt:RELATED-TO:P10503 , UniProt:RELATED-TO:P74275 , UniProt:RELATED-TO:P95629 , UniProt:RELATED-TO:Q9JSY1 , UniProt:RELATED-TO:Q9K0Z9 , UniProt:RELATED-TO:Q9PMG0 , UniProt:RELATED-TO:Q9ZN12 , UniProt:RELATED-TO:Q59426
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