MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Escherichia coli K-12 substr. MG1655: pyrroline-5-carboxylate reductaseInferred from experiment: proC
Homo sapiens: pyrroline-5-carboxylate reductase 1Inferred from experiment: PYCR1
Hordeum vulgare: pyrroline-5-carboxylate reductaseInferred from experiment
Saccharomyces cerevisiae: pyrroline-5-carboxylate reductase: PRO3
Tetrahymena pyriformis: pyrroline-5-carboxylate reductaseInferred from experiment
[Clostridium] sticklandii: PCA reductaseInferred from experiment: proC

In Pathway: L-proline biosynthesis II (from arginine), L-arginine degradation VI (arginase 2 pathway), L-ornithine degradation II (Stickland reaction), L-proline biosynthesis I, L-proline biosynthesis III

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: pyrroline-5-carboxylate reductase

Enzyme Commission Synonyms: proline oxidase, L-proline oxidase, 1-pyrroline-5-carboxylate reductase, NADPH-L1-pyrroline carboxylic acid reductase, L-proline-NAD(P)+ 5-oxidoreductase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -23.393555Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This is the third and terminal step in proline biosynthesis.

Citations: [Yura59, Smith56, Meister57, Aams60]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R01248, KEGG:R01251

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, UniProt:RELATED-TO:P0A9L8, UniProt:RELATED-TO:P14383, UniProt:RELATED-TO:P17817, UniProt:RELATED-TO:P22008, UniProt:RELATED-TO:P27771, UniProt:RELATED-TO:P32263, UniProt:RELATED-TO:P32322, UniProt:RELATED-TO:P46725, UniProt:RELATED-TO:P54904, UniProt:RELATED-TO:P74572, UniProt:RELATED-TO:Q9CEF7, UniProt:RELATED-TO:Q9JWW2, UniProt:RELATED-TO:Q9PNL8, UniProt:RELATED-TO:Q04708, UniProt:RELATED-TO:Q12641, UniProt:RELATED-TO:Q12740


Aams60: Aams E, Goldstone A (1960). "Hydroxyproline metabolism. III. Enzymatic synthesis of hydroxyproline from Delta 1-pyrroline-3-hydroxy-5-carboxylate." J Biol Chem 235;3499-503. PMID: 13681369

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Meister57: Meister A, Radhakrishnan AN, Buckley SD (1957). "Enzymatic synthesis of L-pipecolic acid and L-proline." J Biol Chem 229(2);789-800. PMID: 13502341

Smith56: Smith ME, Greenberg DM (1956). "Characterization of an enzyme reducing pyrroline-5-carboxylate to proline." Nature 177(4520);1130. PMID: 13334497

Yura59: Yura T, Vogel HJ (1959). "Pyrroline-5-carboxylate reductase of Neurospora crassa; partial purification and some properties." J Biol Chem 234(2);335-8. PMID: 13630905

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Mon Nov 30, 2015, biocyc13.