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MetaCyc Reaction: 1.5.1.2

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.5.1.2

Enzymes and Genes:
pyrroline-5-carboxylate reductase Inferred from experiment : proC ( Escherichia coli K-12 substr. MG1655 )
pyrroline-5-carboxylate reductase : PRO3 ( Saccharomyces cerevisiae )
pyrroline-5-carboxylate reductase 1 Inferred from experiment : PYCR1 ( Homo sapiens )
pyrroline-5-carboxylate reductase Inferred from experiment ( Tetrahymena pyriformis )
pyrroline-5-carboxylate reductase Inferred from experiment ( Hordeum vulgare )
PCA reductase Inferred from experiment : proC ( [Clostridium] sticklandii )

In Pathway: proline biosynthesis III , proline biosynthesis II (from arginine) , arginine degradation VI (arginase 2 pathway) , ornithine degradation II (Stickland reaction) , proline biosynthesis I

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: pyrroline-5-carboxylate reductase

Enzyme Commission Synonyms: proline oxidase, L-proline oxidase, 1-pyrroline-5-carboxylate reductase, NADPH-L1-pyrroline carboxylic acid reductase, L-proline-NAD(P)+ 5-oxidoreductase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -23.393555 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
This is the third and terminal step in proline biosynthesis.

Citations: [Yura59, Smith56, Meister57, Aams60]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R01251

Relationship Links: BRENDA:EC:1.5.1.2 , ENZYME:EC:1.5.1.2 , IUBMB-ExplorEnz:EC:1.5.1.2 , UniProt:RELATED-TO:P0A9L8 , UniProt:RELATED-TO:P14383 , UniProt:RELATED-TO:P17817 , UniProt:RELATED-TO:P22008 , UniProt:RELATED-TO:P27771 , UniProt:RELATED-TO:P32263 , UniProt:RELATED-TO:P32322 , UniProt:RELATED-TO:P46725 , UniProt:RELATED-TO:P54904 , UniProt:RELATED-TO:P74572 , UniProt:RELATED-TO:Q9CEF7 , UniProt:RELATED-TO:Q9JWW2 , UniProt:RELATED-TO:Q9PNL8 , UniProt:RELATED-TO:Q04708 , UniProt:RELATED-TO:Q12641 , UniProt:RELATED-TO:Q12740


References

Aams60: Aams E, Goldstone A (1960). "Hydroxyproline metabolism. III. Enzymatic synthesis of hydroxyproline from Delta 1-pyrroline-3-hydroxy-5-carboxylate." J Biol Chem 235;3499-503. PMID: 13681369

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Meister57: Meister A, Radhakrishnan AN, Buckley SD (1957). "Enzymatic synthesis of L-pipecolic acid and L-proline." J Biol Chem 229(2);789-800. PMID: 13502341

Smith56: Smith ME, Greenberg DM (1956). "Characterization of an enzyme reducing pyrroline-5-carboxylate to proline." Nature 177(4520);1130. PMID: 13334497

Yura59: Yura T, Vogel HJ (1959). "Pyrroline-5-carboxylate reductase of Neurospora crassa; partial purification and some properties." J Biol Chem 234(2);335-8. PMID: 13630905


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sat Jan 31, 2015, BIOCYC14A.