MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Paenibacillus polymyxa: (R-acetoin forming)-(R,R)-2,3-butanediol dehydrogenaseInferred from experiment
Saccharomyces cerevisiae: (R,R)-butanediol dehydrogenaseInferred from experiment: BDH1

In Pathway: (R,R)-butanediol biosynthesis, (R,R)-butanediol degradation

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: (R,R)-butanediol dehydrogenase

Enzyme Commission Synonyms: butyleneglycol dehydrogenase, D-butanediol dehydrogenase, D-(-)-butanediol dehydrogenase, butylene glycol dehydrogenase, diacetyl (acetoin) reductase, D-aminopropanol dehydrogenase, 1-amino-2-propanol dehydrogenase, 2,3-butanediol dehydrogenase, D-1-amino-2-propanol dehydrogenase, (R)-diacetyl reductase, (R)-2,3-butanediol dehydrogenase, D-1-amino-2-propanol:NAD+ oxidoreductase, 1-amino-2-propanol oxidoreductase, aminopropanol oxidoreductase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 1.0817871Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Also converts diacetyl into acetoin with NADH as reductant.

Citations: [Strecker54, Taylor60]

Gene-Reaction Schematic

Gene-Reaction Schematic

Instance reaction of [acetoin + NAD+ ← diacetyl + NADH + H+] (1.1.1.-):
i2: (R)-acetoin + NAD+ ← diacetyl + NADH + H+ (

Unification Links: KEGG:R02946, Rhea:24340

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, UniProt:RELATED-TO:Q9CH42, UniProt:RELATED-TO:Q04520

Revised 11-Sep-2012 by Caspi R, SRI International


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Strecker54: Strecker, H.J., Harary, I. (1954). "Bacterial butylene glycol dehydrogenase and diacetyl reductase." J Biol Chem 211(1);263-70. PMID: 13211662

Taylor60: Taylor, MB, Juni, E (1960). "Stereoisomeric specificities of 2,3-butanediol dehydrogenases." Biochim Biophys Acta 39;448-57. PMID: 13837186

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.5 on Wed Nov 25, 2015, BIOCYC11A.