Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 2.2.1.11

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.2.1.11

Enzymes and Genes:
6-deoxy-5-ketofructose 1-phosphate synthase Inferred from experiment : MJ1585 ( Methanocaldococcus jannaschii )

In Pathway: 3-dehydroquinate biosynthesis II (archaea)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 6-deoxy-5-ketofructose 1-phosphate synthase

Enzyme Commission Synonyms: DKFP synthase, MJ1585 (gene name)

Standard Gibbs Free Energy (ΔrG in kcal/mol): 0.13647461 Inferred by computational analysis [Latendresse, 2013]

Enzyme Commission Summary:
The enzyme plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. The enzyme can also catalyse the reaction of EC 4.1.2.13, fructose-bisphosphate aldolase.

Citations: [White06, Samland08]

Gene-Reaction Schematic: ?

Unification Links: Rhea:31914

Relationship Links: BRENDA:EC:2.2.1.11 , ENZYME:EC:2.2.1.11 , IUBMB-ExplorEnz:EC:2.2.1.11

Credits:
Revised 13-Jan-2012 by Caspi R , SRI International


References

Latendresse, 2013: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Samland08: Samland AK, Wang M, Sprenger GA (2008). "MJ0400 from Methanocaldococcus jannaschii exhibits fructose-1,6-bisphosphate aldolase activity." FEMS Microbiol Lett 281(1);36-41. PMID: 18318840

White06: White RH, Xu H (2006). "Methylglyoxal is an intermediate in the biosynthesis of 6-deoxy-5-ketofructose-1-phosphate: a precursor for aromatic amino acid biosynthesis in Methanocaldococcus jannaschii." Biochemistry 45(40);12366-79. PMID: 17014089


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sat Nov 22, 2014, BIOCYC14B.