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MetaCyc Reaction: 2.2.1.11

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 2.2.1.11

Enzymes and Genes:

Methanocaldococcus jannaschii: 6-deoxy-5-ketofructose 1-phosphate synthaseInferred from experiment: MJ1585

In Pathway: 3-dehydroquinate biosynthesis II (archaea)

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: 6-deoxy-5-ketofructose 1-phosphate synthase

Enzyme Commission Synonyms: DKFP synthase, MJ1585 (gene name)

Standard Gibbs Free Energy (ΔrG in kcal/mol): 0.13647461Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
The enzyme plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. The enzyme can also catalyse the reaction of EC 4.1.2.13, fructose-bisphosphate aldolase.

Citations: [White06, Samland08]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: Rhea:31914

Relationship Links: BRENDA:EC:2.2.1.11, ENZYME:EC:2.2.1.11, IUBMB-ExplorEnz:EC:2.2.1.11

Credits:
Revised 13-Jan-2012 by Caspi R, SRI International


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Samland08: Samland AK, Wang M, Sprenger GA (2008). "MJ0400 from Methanocaldococcus jannaschii exhibits fructose-1,6-bisphosphate aldolase activity." FEMS Microbiol Lett 281(1);36-41. PMID: 18318840

White06: White RH, Xu H (2006). "Methylglyoxal is an intermediate in the biosynthesis of 6-deoxy-5-ketofructose-1-phosphate: a precursor for aromatic amino acid biosynthesis in Methanocaldococcus jannaschii." Biochemistry 45(40);12366-79. PMID: 17014089


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Thu May 5, 2016, biocyc14.