MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:

Methanocaldococcus jannaschii : GTP cyclohydrolase IV Inferred from experiment : mptA

In Pathway: 6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (archaea)

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: GTP cyclohydrolase IV

Enzyme Commission Synonyms: MptA, GTP cyclohydrolase MptA

Standard Gibbs Free Energy (ΔrG in kcal/mol): -15.475769 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Requires Fe2+. A zinc protein. This enzyme is involved in tetrahydromethanopterin biosynthesis in methanogenic archaea. cf. EC, GTP cyclohydrolase I, EC, GTP cyclohydrolase II and EC, GTP cyclohydrolase IIa.

Citations: [Grochowski07]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: Rhea:25860

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:


Grochowski07: Grochowski LL, Xu H, Leung K, White RH (2007). "Characterization of an Fe(2+)-dependent archaeal-specific GTP cyclohydrolase, MptA, from Methanocaldococcus jannaschii." Biochemistry 46(22);6658-67. PMID: 17497938

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Tue Oct 6, 2015, biocyc14.