|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 220.127.116.11
Enzymes and Genes:
|Methanocaldococcus jannaschii:||GTP cyclohydrolase IV: mptA|
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: GTP cyclohydrolase IV
Enzyme Commission Synonyms: MptA, GTP cyclohydrolase MptA
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -15.475769 [Latendresse13]
Enzyme Commission Summary:
Requires Fe2+. A zinc protein. This enzyme is involved in tetrahydromethanopterin biosynthesis in methanogenic archaea. cf. EC 18.104.22.168, GTP cyclohydrolase I, EC 22.214.171.124, GTP cyclohydrolase II and EC 126.96.36.199, GTP cyclohydrolase IIa.
Unification Links: Rhea:25860
Grochowski07: Grochowski LL, Xu H, Leung K, White RH (2007). "Characterization of an Fe(2+)-dependent archaeal-specific GTP cyclohydrolase, MptA, from Methanocaldococcus jannaschii." Biochemistry 46(22);6658-67. PMID: 17497938
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