MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Methanocaldococcus jannaschii: GTP cyclohydrolase IVInferred from experiment: mptA

In Pathway: 6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (archaea)

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: GTP cyclohydrolase IV

Enzyme Commission Synonyms: MptA, GTP cyclohydrolase MptA

Standard Gibbs Free Energy (ΔrG in kcal/mol): -15.475769Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Requires Fe2+. A zinc protein. This enzyme is involved in tetrahydromethanopterin biosynthesis in methanogenic archaea. cf. EC, GTP cyclohydrolase I, EC, GTP cyclohydrolase II and EC, GTP cyclohydrolase IIa.

Citations: [Grochowski07]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: Rhea:25860

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:


Grochowski07: Grochowski LL, Xu H, Leung K, White RH (2007). "Characterization of an Fe(2+)-dependent archaeal-specific GTP cyclohydrolase, MptA, from Methanocaldococcus jannaschii." Biochemistry 46(22);6658-67. PMID: 17497938

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Fri Nov 27, 2015, biocyc14.