|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 18.104.22.168
Enzymes and Genes:
|Methanocaldococcus jannaschii :||GTP cyclohydrolase IV
The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.
Most BioCyc compounds have been protonated to a reference pH value of 7.3, and some reactions have been computationally balanced for hydrogen by adding free protons. Please see the PGDB Concepts Guide for more information.
Mass balance status: Balanced.
Enzyme Commission Primary Name: GTP cyclohydrolase IV
Enzyme Commission Synonyms: MptA, GTP cyclohydrolase MptA
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -15.475769 [Latendresse13]
Enzyme Commission Summary:
Requires Fe2+. A zinc protein. This enzyme is involved in tetrahydromethanopterin biosynthesis in methanogenic archaea. cf. EC 22.214.171.124, GTP cyclohydrolase I, EC 126.96.36.199, GTP cyclohydrolase II and EC 188.8.131.52, GTP cyclohydrolase IIa.
Unification Links: Rhea:25860
Grochowski07: Grochowski LL, Xu H, Leung K, White RH (2007). "Characterization of an Fe(2+)-dependent archaeal-specific GTP cyclohydrolase, MptA, from Methanocaldococcus jannaschii." Biochemistry 46(22);6658-67. PMID: 17497938
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