MetaCyc Reaction: [no EC number assigned]

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Mass balance status: Marked as unbalanced.

The substrate, fatty acyl-CoA is at least 18-carbons (C18) in length. The product, very long chain fatty acyl-CoA is longer than C18 in length and up to C32 in length. The reaction adds a C2 to the substrate and extends its length by 2 carbons each reaction. Different fatty acid elongases have different substrate specificities, i.e. they catalyze substrates having different carbon chain length and different degrees of saturation [Millar99].


Millar99: Millar AA, Clemens S, Zachgo S, Giblin EM, Taylor DC, Kunst L (1999). "CUT1, an Arabidopsis gene required for cuticular wax biosynthesis and pollen fertility, encodes a very-long-chain fatty acid condensing enzyme." Plant Cell 1999;11(5);825-38. PMID: 10330468

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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