MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:

Zea mays : polyamine oxidase (propane-1,3-diamine forming) Inferred from experiment : MPAO

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Enzyme Commission Primary Name: polyamine oxidase (propane-1,3-diamine-forming)

Enzyme Commission Synonyms: MPAO, maize PAO

Taxonomic Range: Viridiplantae

Standard Gibbs Free Energy (ΔrG in kcal/mol): -22.204773 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A flavoprotein (FAD). This enzyme, found in the cell walls of monocot plants, oxidizes spermine and spermidine at the four-carbon side of their secondary amine, forming propane-1,3-diamine and hydrogen peroxide [Tavladoraki98]. As the products cannot be converted directly to other polyamines, this class of polyamine oxidases is considered to be involved in the terminal catabolism of polyamines. The enzyme also accepts N1-acetylspermine as substrate, but is quickly inactivated during the reaction [Sebela01].

Citations: [Federico96]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Unification Links: Rhea:25996

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC:


Federico96: Federico, R., Ercolini L., Laurenzi M., Angelini R. (1996). "Oxidation of acetylpolyamines by maize polyamine oxidase." Phytochemistry 43(2):339-341.

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Sebela01: Sebela M, Radova A, Angelini R, Tavladoraki P, Frebort , Pec P (2001). "FAD-containing polyamine oxidases: a timely challenge for researchers in biochemistry and physiology of plants." Plant Sci 160(2);197-207. PMID: 11164591

Tavladoraki98: Tavladoraki P, Schinina ME, Cecconi F, Di Agostino S, Manera F, Rea G, Mariottini P, Federico R, Angelini R (1998). "Maize polyamine oxidase: primary structure from protein and cDNA sequencing." FEBS Lett 426(1);62-6. PMID: 9598979

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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