Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
twitter

MetaCyc Reaction: 1.5.3.14

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 1.5.3.14

Enzymes and Genes:
polyamine oxidase (propane-1,3-diamine-forming) Inferred from experiment ( Glycine max )
polyamine oxidase (propane-1,3-diamine forming) Inferred from experiment : BPAO2 ( Hordeum vulgare )
polyamine oxidase (propane-1,3-diamine forming) Inferred from experiment : MPAO ( Zea mays )

In Pathway: spermine and spermidine degradation II

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: polyamine oxidase (propane-1,3-diamine-forming)

Enzyme Commission Synonyms: MPAO, maize PAO

Standard Gibbs Free Energy (ΔrG in kcal/mol): -22.204742 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A flavoprotein (FAD). This enzyme, found in the cell walls of monocot plants, oxidizes spermine and spermidine at the four-carbon side of their secondary amine, forming propane-1,3-diamine and hydrogen peroxide [Tavladoraki98]. As the products cannot be converted directly to other polyamines, this class of polyamine oxidases is considered to be involved in the terminal catabolism of polyamines. The enzyme also accepts N1-acetylspermine as substrate, but is quickly inactivated during the reaction [Sebela01].

Gene-Reaction Schematic: ?

Unification Links: KEGG:R01914 , Rhea:25820

Relationship Links: BRENDA:EC:1.5.3.14 , ENZYME:EC:1.5.3.14 , IUBMB-ExplorEnz:EC:1.5.3.14

Credits:
Created 05-Aug-2009 by Caspi R , SRI International


References

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Sebela01: Sebela M, Radova A, Angelini R, Tavladoraki P, Frebort , Pec P (2001). "FAD-containing polyamine oxidases: a timely challenge for researchers in biochemistry and physiology of plants." Plant Sci 160(2);197-207. PMID: 11164591

Tavladoraki98: Tavladoraki P, Schinina ME, Cecconi F, Di Agostino S, Manera F, Rea G, Mariottini P, Federico R, Angelini R (1998). "Maize polyamine oxidase: primary structure from protein and cDNA sequencing." FEBS Lett 426(1);62-6. PMID: 9598979


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Thu Nov 20, 2014, biocyc14.