MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Glycine max: polyamine oxidase (propane-1,3-diamine-forming)Inferred from experiment
Hordeum vulgare: polyamine oxidase (propane-1,3-diamine forming)Inferred from experiment: BPAO2
Zea mays: polyamine oxidase (propane-1,3-diamine forming)Inferred from experiment: MPAO

In Pathway: spermine and spermidine degradation II

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Enzyme Commission Primary Name: polyamine oxidase (propane-1,3-diamine-forming)

Enzyme Commission Synonyms: MPAO, maize PAO

Standard Gibbs Free Energy (ΔrG in kcal/mol): -22.204742Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
A flavoprotein (FAD). This enzyme, found in the cell walls of monocot plants, oxidizes spermine and spermidine at the four-carbon side of their secondary amine, forming propane-1,3-diamine and hydrogen peroxide [Tavladoraki98]. As the products cannot be converted directly to other polyamines, this class of polyamine oxidases is considered to be involved in the terminal catabolism of polyamines. The enzyme also accepts N1-acetylspermine as substrate, but is quickly inactivated during the reaction [Sebela01].

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R01914, Rhea:25820

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:

Created 05-Aug-2009 by Caspi R, SRI International


Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Sebela01: Sebela M, Radova A, Angelini R, Tavladoraki P, Frebort , Pec P (2001). "FAD-containing polyamine oxidases: a timely challenge for researchers in biochemistry and physiology of plants." Plant Sci 160(2);197-207. PMID: 11164591

Tavladoraki98: Tavladoraki P, Schinina ME, Cecconi F, Di Agostino S, Manera F, Rea G, Mariottini P, Federico R, Angelini R (1998). "Maize polyamine oxidase: primary structure from protein and cDNA sequencing." FEBS Lett 426(1);62-6. PMID: 9598979

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Wed Nov 25, 2015, biocyc13.