|Superclasses:||Reactions Classified By Conversion Type → Simple Reactions → Chemical Reactions|
|Reactions Classified By Substrate → Small-Molecule Reactions|
EC Number: 188.8.131.52
Enzymes and Genes:
|Glycine max:||polyamine oxidase (propane-1,3-diamine-forming)|
|Hordeum vulgare:||polyamine oxidase (propane-1,3-diamine forming): BPAO2|
|Zea mays:||polyamine oxidase (propane-1,3-diamine forming): MPAO|
In Pathway: spermine and spermidine degradation II
The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.
Mass balance status: Balanced.
Enzyme Commission Primary Name: polyamine oxidase (propane-1,3-diamine-forming)
Enzyme Commission Synonyms: MPAO, maize PAO
Standard Gibbs Free Energy (ΔrG'° in kcal/mol): -22.204742 [Latendresse13]
Enzyme Commission Summary:
A flavoprotein (FAD). This enzyme, found in the cell walls of monocot plants, oxidizes spermine and spermidine at the four-carbon side of their secondary amine, forming propane-1,3-diamine and hydrogen peroxide [Tavladoraki98]. As the products cannot be converted directly to other polyamines, this class of polyamine oxidases is considered to be involved in the terminal catabolism of polyamines. The enzyme also accepts N1-acetylspermine as substrate, but is quickly inactivated during the reaction [Sebela01].
Sebela01: Sebela M, Radova A, Angelini R, Tavladoraki P, Frebort , Pec P (2001). "FAD-containing polyamine oxidases: a timely challenge for researchers in biochemistry and physiology of plants." Plant Sci 160(2);197-207. PMID: 11164591
Tavladoraki98: Tavladoraki P, Schinina ME, Cecconi F, Di Agostino S, Manera F, Rea G, Mariottini P, Federico R, Angelini R (1998). "Maize polyamine oxidase: primary structure from protein and cDNA sequencing." FEBS Lett 426(1);62-6. PMID: 9598979
©2016 SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025-3493